allicin

Allicin exerts antioxidant, bactericidal, anti-cancer, anti-inflammatory activities, it exerts an inhibitory immunomodulatory effect on intestinal epithelial cells. Allicin could significantly inhibit vascular smooth muscle cells' proliferation and migration induced by insulin, which may be related to the inhibition of the activation of ERK signal path. Allicin is beneficial in reducing blood cholesterol, triglycerides levels and systolic blood pressure in hypercholesterolemic rats, it may beneficially affect two risk factors for atherosclerosis-hyperlipidemia and hypertension.

Brostallicin, a DNA minor groove binder, has demonstrated promising activity in preclinical studies both in vitro and in vivo against various human tumors.

Brostallicin is a synthetic, alpha-bromoacrylic, second-generation minor groove binder (MGB), related to distamycin A, with potential antineoplastic activity. Brostallicin binds to DNA minor groove DNA, after having formed a highly reactive glutathione (GSH)-brostallicin complex in the presence of the enzyme glutathione S-transferase (GST), which is overexpressed in cancer cells; DNA replication and cell division are inhibited, resulting in tumor cell death. Compared to typical MGBs, this agent appears to bind covalently to DNA in a different manner and its activity does not depend on a functional DNA mismatch repair (MMR) mechanism. Accordingly, brostallicin may be effective against MMR-defective tumors that are refractory to various anticancer agents.

Methyl gallate (Gallincin) is a reverse transcriptase inhibitor with antioxidant, anti-HIV-1 and HIV-1 enzyme inhibition activities.

MP-1 is a covalent inhibitor of fumarate hydratase (FH) that exhibits cytotoxicity dependent on FH. MP-1 engages a functional cysteine in the Zn-finger domain of the tRNA methyltransferase enzyme TRMT1.

Antibacterial agent 243 is a potent antimicrobial compound with EC50 values of 0.64 mg/L for Valsa mali, 26 mg/L for allicin, and 0.33 mg/L for tebuconazole. It induces hyphal contraction and collapse, triggers the accumulation of reactive oxygen species within cells, modulates antioxidant enzyme activity, initiates lipid peroxidation, and ultimately causes irreversible oxidative damage to Valsa mali cells.

(±)-Alliin is a derivative of cysteine and a natural component of fresh garlic that can be converted into allicin by alliinase.

(±)-Alliin (Standard) is a reference standard for research and analysis in studies involving (±)-Alliin. (±)-Alliin is a derivative of cysteine and a natural component of fresh garlic that can be converted into allicin by alliinase.

Garlic Extract is a derivative of garlic, containing the active component allicin. It holds promise in reducing the risk of cardiovascular diseases. Garlic Extract is effective in lowering total cholesterol and low-density lipoprotein (LDL) levels, while also improving high-density lipoprotein (HDL) levels.