alkyne peg4 ss peg4 alkyne

Alkyne-PEG4-SS-PEG4-alkyne is an eight-unit polyethylene glycol (PEG) linker designed for antibody-drug conjugate (ADC) synthesis, enabling cleavage and controlled drug release under specific conditions [1].

Biotin-PEG4-SS-azide, a biotin-labeled ADC linker, is primarily utilized in the synthesis of antibody-drug conjugates (ADCs). This compound serves as a click chemistry reagent featuring an Azide group, enabling it to partake in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-bearing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.