akt inhibitor x

Akt Inhibitor X is a cell-permeable and reversible inhibitor of Akt phosphorylation.

1. Glaucocalyxin A (Leukamenin F)-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase-3, decreases BAD phosphorylation, and reduces the expression of X-linked inhibitor of apoptosis protein. 3. Glaucocalyxin A inhibits Akt phosphorylation, suppresses proliferation, and promotes apoptosis in a dose-dependent manner, but not in normal glial cells. 4. Glaucocalyxin A inhibits collagen-stimulated tyrosine phosphorylation of Syk, LAT, and phospholipase Cγ2, the signaling events in collagen receptor GPⅥ pathway. 5. Glaucocalyxin A could potentially be developed as an antiplatelet and antithrombotic agent, can inhibit platelet p-selectin secretion and integrin activation by convulxin, is a GPVI selective ligand.

Hit 14, a CXCR4 (C-X-C chemokine receptor type 4) inhibitor, demonstrates an IC50 of 254 nM. It inhibits migration and invasion of MDA-MB-231 cells and suppresses Akt phosphorylation, exhibiting anti-inflammatory activity. Furthermore, Hit 14 improves ear swelling and damage in a mouse model.