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Results for "
afn-1252 tosylate
" in TargetMol Product Catalog- Inhibitors & Agonists3
AFN-1252 tosylate
API-1252 tosylate
T4105L1047981-31-6
AFN-1252 tosylate is an enoyl-ACP Reductase inhibitor.
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AFN-1252 tosylate hydrate
T715391047981-30-5
AFN-1252, also known as AFN-12520000; API-1252; Debio-1452, is FASII Inhibitor which is potentially for the treatment of acute bacterial skin. AFN-1252 exhibits typical MIC(90) values of ≤0·015 μg ml against diverse clinical isolates of S. aureus, oral absorption, long elimination half-live and efficacy in animal models. AFN-1252 efficiently blocked daptomycin-induced phospholipid decoy production, even in the case of isolates resistant to AFN-1252, which prevented the inactivation of daptomycin and resulted in sustained bacterial killing. In turn, daptomycin prevented the fatty acid-dependent emergence of AFN-1252-resistant isolates in vitr
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