ac 42

AC-42 is an allosteric agonist of M1 muscarinic receptor.

AC-42 hydrochloride is the hydrochloride salt form of AC-42. It acts as a conformational agonist of the muscarinic M1 receptor (muscarinic M1 receptor), exhibiting EC50 values of 805 nM and 220 nM on human wild-type and Y381A mutant M1 receptors, respectively. Additionally, AC-42 hydrochloride stimulates the accumulation of inositol phosphates (IP) and calcium mobilization in CHO cells.

Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2 exhibits serum stability and is non-toxic to neuronal cells, selectively inhibiting tau fibrillization over Aβ 42.

Phosphopeptide ligand for the src SH2 domain (IC50 = 42 nM); displays 30-fold higher affinity than N-acetyl-O-phosphono-Tyr-Glu-Glu-Ile-Glu (Ac-pYEEIE,).