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(2)
By Target- Epigenetic Reader Domain
- Histone Acetyltransferase(2)
- Apoptosis(1)
- Caspase(1)
- PARP(1)
- PROTACs(1)
- Parasite(1)
- Others(2)
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Search Result
Results for "
a485
" in TargetMol Product Catalog- Inhibitors & Agonists3
- Dye Reagents1
- PROTAC Products1
- Recombinant Protein1
A-485
T140731889279-16-6
A-485 is a potent and selective catalytic p300/CBP inhibitor with IC50 values of 9.8 nM for p300 and 2.6 nM for CBP.
- $85
Size
QTY
Bitriben
Fluorescent Red Mega 485 NHS-ester, Cloxil, Chloxyl, Chloxil, Chloksil
T2062468-36-0
Bitriben is an agent with the anthelmintic effect.
- $1,520
Size
QTY
JQAD1
Cited
T411802417097-18-6
JQAD1 is a potent and selective histone acetyltransferase EP300 degrader (PROTAC®; DC50≤ 31.6 nM); comprises an EP300 inhibitor, A485, joined by a linker to a cereblon E3 ligase ligand. JQAD1 brings about degradation of EP300 in neuroblastoma cell lines in a proteasome-dependent manner. JQAD1 suppresses both H3K27ac and EP300 expression levels and induces apoptosis. JQAD1 suppresses tumors growth in NSG mice xenografted with Kelly cells. CRC and MYCN genes are downregulated in tumors treated with JQAD1. JQAD1 exhibits no significant effect on coactivator CBP at concentrations inducing EP300 degradation.
- $123
Size
QTY
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