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Search Results for " trk receptor "

Targets

38

Compounds

36

Recombinant Proteins

Cat No. Product Name
T41284 Nalfurafine TRK-820 Opioid Receptor
Nalfurafine (TRK-820) is an effective and selective agonist of G protein-biased κ-opioid receptor with high translationa...
T2388 Nalfurafine hydrochloride TRK-820 hydrochloride Opioid Receptor
Nalfurafine hydrochloride (TRK-820 hydrochloride) is an opioid κ-selective agonist; has been approved in Japan for treat...
T14921 CE-245677 Tie-2 , Trk receptor
CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases. With a cellular IC50s of 4.7 and 1 nM.
T7568 LM22A-4 Trk receptor
LM22A-4 is a brain-derived neurotrophic factor (BDNF) mimetic and agonist of the receptor tropomyosin-related kinase B (...
T5635 CH7057288 Trk receptor
CH7057288 is an effective and selective TRK inhibitor with an IC50 value of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and...
T14363 AZ-23 AZ 23,AZ23 Trk receptor
AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C. For TrkA, TrkB, FGFR1, Flt3, Ret, MuSk, Lck, the IC50s va...
T7435 Selitrectinib LOXO-195 Trk receptor
Selitrectinib (LOXO-195) is a potent and selective inhibitor of the receptor tyrosine kinases(TRK)( TrkA and TrkC with I...
T2359 ANA-12 ANA 12,ANA12 Trk receptor
ANA-12 is a potent and selective TrkB antagonist with anxiolytic and antidepressant activity in mice.
T6097 GNF-5837 GNF 5837 Trk receptor , PDGFR , c-Kit
GNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM).
T6052 GW 441756 Apoptosis , Raf , Trk receptor , CDK
GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM.
T9123 DS-1205 TAM Receptor
DS-1205 is a potent and selective inhibitor of AXL kinase, with an IC50 of 1.3 nM. DS-1205 also inhibits MER, MET, and T...
T8327 ONO-7475 Trk receptor , TAM Receptor
ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase
T2816 7,8-Dihydroxyflavone 7,8-DHF Apoptosis , Trk receptor
7,8-Dihydroxyflavone (7,8-DHF) is a naturally-occurring flavone and exist in Tridax procumbens, Godmania aesculifolia, a...
T4496 LM22B-10 LM22B10 ERK , Trk receptor , Akt
LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and AKT activation in vitro a...
T4257 Belizatinib TSR-011 Trk receptor , ALK
Belizatinib (TSR-011) is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA...
T19649 PF-06273340 PF 6273340,PF 06273340,PF6273340,PF-6273340 Trk receptor
PF-06273340 is an effective, Selective, and Peripherally Restricted Pan-Trk inhibitor (IC50: Trk-A = 6 nM; Trk-B = 4 nM;...
T5995 Larotrectinib LOXO-101,ARRY-470 Apoptosis , Trk receptor
Larotrectinib (LOXO-101) is an orally administered inhibitor of the TRK kinase and is highly selective only for the TRK ...
T4071 Repotrectinib TPX-0005,TPX 0005,TPX0005 Trk receptor , ROS , Src , ALK , ROS Kinase
Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01 nM, 5.3 nM, 1.08 nM and 1.26 nM for WT AL...
T2054 Altiratinib DCC-2701 VEGFR , Tie-2 , FLT , Trk receptor , c-Met/HGFR
Altiratinib (DCC-2701)(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and blo...
T1354 N-Acetyl-5-hydroxytryptamine Normelatonin,O-Demethylmelatonin,N-Acetylserotonin Trk receptor , Endogenous Metabolite
N-Acetyl-5-hydroxytryptamine (O-Demethylmelatonin) , also known as Normelatonin, is the immediate precursor of melatonin...
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Cat No. Product Name Species Source
TMPY-01084 TrkA Protein, Human, Recombinant (His) Human HEK293
TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. It is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by the pluripotent neural stem and neural crest progenitors. The prese...
TMPY-02231 TrkB Protein, Mouse, Recombinant (His) Mouse HEK293
TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptor with intracellular tyrosine kinase activity. TrkB/NTRK2 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TrkB tyrosine kinase (TrkB) or NTRK2 is coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3-K, and PLCgamma signaling pathways. There are four members of the Trk family; TrkA, TrkB, and Trk...
TMPY-00751 TrkB Protein, Human, Recombinant (His) Human HEK293
TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptor with intracellular tyrosine kinase activity. TrkB/NTRK2 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TrkB tyrosine kinase (TrkB) or NTRK2 is coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3-K, and PLCgamma signaling pathways. There are four members of the Trk family; TrkA, TrkB, and Trk...
TMPY-01760 TrkA Protein, Human, Recombinant (aa 194-413, His) Human HEK293
TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. It is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by the pluripotent neural stem and neural crest progenitors. The prese...
TMPY-01759 TrkA Protein, Human, Recombinant (aa 285-413, His) Human E. coli
TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. It is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by the pluripotent neural stem and neural crest progenitors. The prese...
TMPY-01083 TrkA Protein, Human, Recombinant (His & hFc) Human HEK293
TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. It is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by the pluripotent neural stem and neural crest progenitors. The prese...
TMPY-03536 TrkA Protein, Mouse, Recombinant (His) Mouse HEK293
TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. It is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by the pluripotent neural stem and neural crest progenitors. The prese...
TMPY-03470 TrkA Protein, Mouse, Recombinant (hFc) Mouse HEK293
TRKA is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. It is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. Isoform TrkA-I is found in most non-neuronal tissues. Isoform TrkA-II is primarily expressed in neuronal cells. TrkA-III is specifically expressed by the pluripotent neural stem and neural crest progenitors. The prese...
TMPY-05509 TrkB Protein, Human, Recombinant (hFc) Human HEK293
TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptor with intracellular tyrosine kinase activity. TrkB/NTRK2 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TrkB tyrosine kinase (TrkB) or NTRK2 is coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3-K, and PLCgamma signaling pathways. There are four members of the Trk family; TrkA, TrkB, and Trk...
TMPY-02614 NGFR/p75NTR Protein, Human, Recombinant (hFc) Human HEK293
Nerve growth factor receptors (NGFRs) belong to a large growth factor receptor family. NGFR includes two types of receptors: high-affinity nerve growth factor receptor and low-affinity nerve growth factor receptor. The high-affinity nerve growth factor receptor is also referred to as the Trk family whose members are bound by some neurotrophins with high affinity.Nerve growth factorbinds with TrkA after being released from target cells, the NGF / TrkA complex is subsequently trafficked back to th...
TMPK-00413 ROR1 Protein, Human/Cynomolgus/Rhesus macaque, Recombinant (His & Avi) Human,Cynomolgus,Rhesus macaque HEK293
ROR1 (Receptor tyrosine kinase-like orphan receptor 1), also known as neurotrophic tyrosine kinase receptor-related 1 (NTRKR1),  is a member of  the ROR family within receptor tyrosine kinases (RTK) superfamily. Two ROR family members (ROR1 and ROR2) have been identified and are characterized by the intracellular tyrosine kinase domains, highly related to those of the Trk-family receptor tyrosine kinases, and by the extracellular Frizzled-like cysteine-rich domains and kringle domains, which are...
TMPK-00572 ROR1 Protein, Canine, Recombinant (His) Canine HEK293
ROR1 (Receptor tyrosine kinase-like orphan receptor 1), also known as neurotrophic tyrosine kinase receptor-related 1 (NTRKR1),  is a member of  the ROR family within receptor tyrosine kinases (RTK) superfamily. Two ROR family members (ROR1 and ROR2) have been identified and are characterized by the intracellular tyrosine kinase domains, highly related to those of the Trk-family receptor tyrosine kinases, and by the extracellular Frizzled-like cysteine-rich domains and kringle domains, which are...
TMPY-00228 TrkB Protein, Canine, Recombinant (hFc) Canine HEK293
TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptor with intracellular tyrosine kinase activity. TrkB/NTRK2 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TrkB tyrosine kinase (TrkB) or NTRK2 is coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3-K, and PLCgamma signaling pathways. There are four members of the Trk family; TrkA, TrkB, and Trk...
TMPY-01163 Nogo Receptor/RTN4R Protein, Mouse, Recombinant (His) Mouse HEK293
Reticulon 4 receptor (RTN4R), also known as Nogo-66 Receptor (NgR), is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family including three members. Mouse RTN4R cDNA contains 1 LRP (Leucine-rich) repeats. RTN4R is expressed predominantly in neurons and their axons in the central nervous systems (CNS). As a receptor for myelin-derived proteins Nogo, myelin-associated glycoprotein (MAG), and myelin oligodendrocyte glycoprotein (OMG), RTN4R mediates axonal growth...
TMPY-03144 Nogo Receptor/RTN4R Protein, Human, Recombinant (His) Human HEK293
Reticulon 4 receptor (RTN4R), also known as Nogo-66 Receptor (NgR), is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family including three members. Mouse RTN4R cDNA contains 1 LRP (Leucine-rich) repeats. RTN4R is expressed predominantly in neurons and their axons in the central nervous systems (CNS). As a receptor for myelin-derived proteins Nogo, myelin-associated glycoprotein (MAG), and myelin oligodendrocyte glycoprotein (OMG), RTN4R mediates axonal growth...
TMPY-03635 TrkB Protein, Canine, Recombinant (His) Canine HEK293
TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptor with intracellular tyrosine kinase activity. TrkB/NTRK2 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TrkB tyrosine kinase (TrkB) or NTRK2 is coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3-K, and PLCgamma signaling pathways. There are four members of the Trk family; TrkA, TrkB, and Trk...
TMPY-02917 TrkB Protein, Rat, Recombinant (hFc) Rat HEK293
TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptor with intracellular tyrosine kinase activity. TrkB/NTRK2 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TrkB tyrosine kinase (TrkB) or NTRK2 is coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3-K, and PLCgamma signaling pathways. There are four members of the Trk family; TrkA, TrkB, and Trk...
TMPY-03162 TrkB Protein, Rat, Recombinant (His) Rat HEK293
TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptor with intracellular tyrosine kinase activity. TrkB/NTRK2 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TrkB tyrosine kinase (TrkB) or NTRK2 is coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3-K, and PLCgamma signaling pathways. There are four members of the Trk family; TrkA, TrkB, and Trk...
TMPY-04831 NGFR/p75NTR Protein, Rabbit, Recombinant (hFc) Rabbit HEK293
Nerve growth factor receptors (NGFRs) belong to a large growth factor receptor family. NGFR includes two types of receptors: high-affinity nerve growth factor receptor and low-affinity nerve growth factor receptor. The high-affinity nerve growth factor receptor is also referred to as the Trk family whose members are bound by some neurotrophins with high affinity.Nerve growth factorbinds with TrkA after being released from target cells, the NGF / TrkA complex is subsequently trafficked back to th...
TMPY-01056 Nogo Receptor/RTN4R Protein, Human, Recombinant (His & hFc) Human HEK293
Reticulon 4 receptor (RTN4R), also known as Nogo-66 Receptor (NgR), is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family including three members. Mouse RTN4R cDNA contains 1 LRP (Leucine-rich) repeats. RTN4R is expressed predominantly in neurons and their axons in the central nervous systems (CNS). As a receptor for myelin-derived proteins Nogo, myelin-associated glycoprotein (MAG), and myelin oligodendrocyte glycoprotein (OMG), RTN4R mediates axonal growth...

Recombinant Proteins

TrkA Protein, Human, Recombinant (His)
TMPY-01084
Species: Human
Source: HEK293
TrkB Protein, Mouse, Recombinant (His)
TMPY-02231
Species: Mouse
Source: HEK293
TrkB Protein, Human, Recombinant (His)
TMPY-00751
Species: Human
Source: HEK293
TrkA Protein, Human, Recombinant (aa 194-413, His)
TMPY-01760
Species: Human
Source: HEK293
TrkA Protein, Human, Recombinant (aa 285-413, His)
TMPY-01759
Species: Human
Source: E. coli
TrkA Protein, Human, Recombinant (His & hFc)
TMPY-01083
Species: Human
Source: HEK293
TrkA Protein, Mouse, Recombinant (His)
TMPY-03536
Species: Mouse
Source: HEK293
TrkA Protein, Mouse, Recombinant (hFc)
TMPY-03470
Species: Mouse
Source: HEK293
TrkB Protein, Human, Recombinant (hFc)
TMPY-05509
Species: Human
Source: HEK293
NGFR/p75NTR Protein, Human, Recombinant (hFc)
TMPY-02614
Species: Human
Source: HEK293
ROR1 Protein, Human/Cynomolgus/Rhesus macaque, Recombinant (His & Avi)
TMPK-00413
Species: Human,Cynomolgus,Rhesus macaque
Source: HEK293
ROR1 Protein, Canine, Recombinant (His)
TMPK-00572
Species: Canine
Source: HEK293
TrkB Protein, Canine, Recombinant (hFc)
TMPY-00228
Species: Canine
Source: HEK293
Nogo Receptor/RTN4R Protein, Mouse, Recombinant (His)
TMPY-01163
Species: Mouse
Source: HEK293
Nogo Receptor/RTN4R Protein, Human, Recombinant (His)
TMPY-03144
Species: Human
Source: HEK293
TrkB Protein, Canine, Recombinant (His)
TMPY-03635
Species: Canine
Source: HEK293
TrkB Protein, Rat, Recombinant (hFc)
TMPY-02917
Species: Rat
Source: HEK293
TrkB Protein, Rat, Recombinant (His)
TMPY-03162
Species: Rat
Source: HEK293
NGFR/p75NTR Protein, Rabbit, Recombinant (hFc)
TMPY-04831
Species: Rabbit
Source: HEK293
Nogo Receptor/RTN4R Protein, Human, Recombinant (His & hFc)
TMPY-01056
Species: Human
Source: HEK293
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TargetMol