T6206

PHA-767491 (CAY10572) is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM, respectively.

COX-2-IN-6 is a potent, selective, and orally available cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 0.84 μM and a Ki of 69 nM.COX-2-IN-6 inhibits COX-2-driven PGE2 synthesis with an IC50 of 0.60 μM.COX-2-IN-6 is used to prevent colorectal cancer. COX-2-IN-6 can be used to prevent colorectal cancer.

NF-κB-IN-5 (compound 4d) is an orally active NF-κB inhibitor that interacts directly with NF-κB, and exhibits antitumor activity against human cancer cell lines, with IC50 values of 5.35, 2.81, 2.83, 2.02, and 3.90 μM for HCT116, U87-MG, HepG2, BGC823, and PC9, respectively.

MAO-B-IN-7 is a potent and blood-brain barrier permeable MAO-B and AChE inhibitor, exhibiting IC50 values of 41 nM for human AChE, 87 nM for electric eel AChE, and 0.3 μM for MAO-B. MAO-B-IN-7 effectively alleviates oxidative stress and neuroinflammatory damage.

Antibacterial agent 76 (compound 9) is a potent antibacterial agent.

c-ABL-IN-4, a potent inhibitor of c-Abl, exhibits strong activity in inhibiting the Bcr-Abl (IC50 = 4.5 nM) kinase activity and proliferation (IC50 = 0.41-2.12 μM) of Bcr-Abl(T315I) cell lines.

Antitubercular agent-29 (compound 6xa) is a potent Mycobacterium tuberculosis (Mtb) inhibitor, effective against drug-resistant (DR) and drug-susceptible (DS) strains with a minimum inhibitory concentration (MIC) of 0.03 μg/mL for DS-Mtb and 0.03-0.06 μg/mL for DR-Mtb strains, and demonstrates favorable selectivity (SI>40) against Vero cells.

TRPC5-IN-3 is a potent TRPC5 inhibitor with an IC50 of 10.75 nM.

Chitin synthase inhibitor 1 is a potent and selective chitin synthase (CHS) inhibitor with an IC50 of 0.12 mM, effectively inhibiting drug-resistant fungi variants.