T21263

Amlodipine maleate (Amvaz) is an orally active dihydropyridine calcium channel blocker that inhibits calcium inward flow by blocking voltage-dependent L-type calcium channels.Amlodipine maleate is used in the study of hypertension and cancer.

JD-13 is a novel and potent Hsp90α inhibitor that binds to the ATP-binding pocket of Hsp90α (Kd = 1.60 μM), downregulates the Akt/β-catenin pathway, inhibits both wild-type and acyclovir-resistant HSV-1 infections, and alleviates skin lesions in guinea pigs caused by HSV-1 infection.

WAY-300009-A serves as a key synthetic intermediate for the preparation of a wide range of biologically and chemically active compounds. XXX enables the development of functionalized derivatives and complex molecular scaffolds, therefore contributing to advanced research in biomedical and pharmaceutical sciences, as well as mechanistic studies in organic and medicinal chemistry.

WAY-382818 serves as a key synthetic intermediate for the preparation of a wide range of biologically and chemically active compounds. WAY-382818 enables the development of functionalized derivatives and complex molecular scaffolds, therefore contributing to advanced research in biomedical and pharmaceutical sciences, as well as mechanistic studies in organic and medicinal chemistry.

GPS167 is a specific small-molecule splicing regulator and SRSF10 inhibitor that modulates BCLAF1 alternative splicing with an IC50 of 2 μM in human colorectal HCT116 cells, while also directly inhibiting CLK1, CLK2, and CLK4 but not SRPK1 or DYRK1A, positioning it as a mechanistically well-defined probe for studying spliceosome regulation and kinase-dependent RNA processing.

Harmine 19a is an antitumor agent based on the structure of the Twist1 inhibitor harmine. It exhibits inhibitory activity against A549 and H2228 cell lines, with IC50 values of 2.03 μM and 9.80 μM respectively, and can be utilized for non - small cell lung cancer (NSCLC).

IDO1-IN-28 (Compound MQ-1) is a selective Apo-IDO1 inhibitor with an IC50 value of 1.29 μM that disrupts heme binding to the apo form of indoleamine 2,3-dioxygenase 1, IDO1-IN-28 is extensively applied in cancer research to investigate immune evasion mechanisms, tryptophan metabolism, and immuno-oncology therapeutic targeting.

CCKBR agonist-2 (Compound z-44) is a CCKBR-Gi-biased agonist that activates the Gi signaling pathway (EC50 = 0.27 nM) with negligible activity on Gq and Gs pathways. It exhibits no significant protective effect in mouse models of Alzheimer's disease.

Amlodipine-D4 Maleate (Racemic) is a deuterated compound of Amlodipine Maleate (Racemic) (T21263). Amlodipine Maleate (Racemic) has a CAS number of 88150-47-4. Amlodipine maleate is an orally active dihydropyridine calcium channel blocker that inhibits calcium inward flow by blocking voltage-dependent L-type calcium channels.Amlodipine maleate is used in the study of hypertension and cancer.