Search Result

Search Results for " plk "

Targets

Compounds

Cat No.	Product Name
T16560	Poloxin		PLK
	Poloxin is a non-ATP competitive Polo-like Kinase 1 inhibitor. It targets the polo-box domain (IC50: appr 4.8 μM).		PLK
T3643	HMN-176		PLK
	HMN-176 is a stilbene derivative which inhibits mitosis, interfering with polo-like kinase-1 (plk1).		PLK
T14927	Centrinone	LCR-263	PLK , Aurora Kinase
	Centrinone (LCR-263) is a reversible inhibitor of polo-like kinase 4 (PLK4; Ki:0.16 nM).		PLK , Aurora Kinase
T2634	Ro3280	RO 3280,Ro5203280	PLK
	Ro3280 is an effective, specific inhibitor of PLK1(IC50=3, Kd=0.09 nM).		PLK
T6282	GSK461364	GSK461364A	PLK
	GSK461364(Ki=2.2 nM) inhibits purified Plk1 .The specificity of GSK461364 for Plk1 is more than 1000-fold over Plk2/3.		PLK
T15454	GW843682X	GW843682	Aurora Kinase , PLK , PDGFR , CDK , VEGFR
	GW843682X is a selective and ATP-competitive inhibitor of PLK1 and PLK3 (IC50s = 2.2 nM and 9.1 nM).		Aurora Kinase , PLK , PDGFR , CDK , VEGFR
T2704	MLN0905	PLK1 Inhibitor	PLK
	MLN0905 is an effective PLK1 inhibitor(IC50=2 nM).		PLK
T10215	AAPK-25		Aurora Kinase , Apoptosis , PLK
	AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and ...		Aurora Kinase , Apoptosis , PLK
T6247	Onvansertib	NMS-P937,NMS-1286937	PLK , Apoptosis
	NMS-P937 (NMS1286937), an oral, specific Polo-like Kinase 1 (PLK1) inhibitor, is with IC50 of 2 nM. The specificity of N...		PLK , Apoptosis
T2438	HMN-214	HMN214,IVX-214	PLK
	HMN-214(IVX214) is a potent PLK1 inhibitor with an average IC50 of 0.12 μM.		PLK
T1839	Mps1-IN-2		Kinesin , PLK
	Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor.		Kinesin , PLK
T7200	TAK-960		PLK
	TAK-960 is an orally bioavailable, selective inhibitor of Plks with IC50 values of 0.8, 16.9, and 50.2 nM for Plk1, Plk2...		PLK
T5818	Rigosertib sodium	Rigosertib,ON-01910,Estybon	PI3K , Apoptosis , PLK
	Rigosertib, a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 a...		PI3K , Apoptosis , PLK
T6217	LFM-A13		PLK , JAK , BTK
	LFM-A13（IC50=2.5 μM）, a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein ki...		PLK , JAK , BTK
T16750	Rigosertib	ON-01910	PDGFR , PI3K , FLT , Bcr-Abl , CDK , PLK , Apoptosis , Src
	Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor...		PDGFR , PI3K , FLT , Bcr-Abl , CDK , PLK , Apoptosis , Src
T22288	(1E)-CFI-400437 dihydrochloride	CFI-400437 dihydrochloride	PLK
	CFI-400437 dihydrochloride is a selective and potent polo-like kinase 4 (PLK4) inhibitor.		PLK
T2271	SBE13 Hydrochloride	SBE 13 HCl,SBE 13 hydrochloride	Apoptosis , Autophagy , PLK
	SBE13 hydrochloride is an effective and specific PLK1 inhibitor (IC50: 0.2 nM); no inhibition om Aurora A kinase, Plk2/3...		Apoptosis , Autophagy , PLK
T19664	ON1231320	GBO-006	PLK , Apoptosis
	ON1231320 is a Polo-like kinase 2 (PLK2) inhibitor.		PLK , Apoptosis
T6283	Wortmannin	KY-12420,SL-2052	Autophagy , DNA-PK , ATM/ATR , PLK , Antibiotic , PI3K , Serine/threonin kinase
	Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM, with little selectivity within the PI3K family. Also...
T21678	3MB-PP1		PLK
	3MB-PP1 is a bulky purine analog and a Polo-like kinase 1 (Plk1) inhibitor. In cells expressing analog-sensitive Plk1 al...		PLK