eif4e — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T40211	eIF4E-IN-1	eIF4E-IN-1
	eIF4E-IN-1 (WO2021003194A1, compound Y), is a highly effective inhibitor of eIF4E, a key protein involved in immunosuppression. By targeting immune checkpoint proteins such as PD-1, PD-L1, LAG3, TIM3, and IDO, eIF4E-IN-1...
T40210	eIF4E-IN-3	eIF4E-IN-3
	eIF4E-IN-3 is a highly effective inhibitor of eukaryotic initiation factor 4e (eIF4e), exhibiting noteworthy potential for investigating eIF4e dependent diseases, particularly cancer research (WO2021003157A1, compound 48...
T40214	eIF4E-IN-2	eIF4E-IN-2
	eIF4E-IN-2 is a highly effective inhibitor of eukaryotic initiation factor 4e (eIF4e). This compound exhibits significant potential in the investigation of eIF4e dependent diseases, particularly in the context of cancer ...
T79525	eIF4E-IN-5
	eIF4E-IN-5 (Compound 6n) is a cell-permeable eIF4E inhibitor that binds to capped mRNA, thereby inhibiting cap-dependent translation [1].
T82489	eIF4E-IN-6
	eIF4E-IN-6 (Compound 4b), a GMP analog, is designed to inhibit the eIF4E protein's ability to bind to cap mRNA. It demonstrates cytotoxic effects on Caco-2, HepG-2, and MCF-7 cell lines with IC50 values of 31, 27, and 21...
T2665	4EGI-1	4EGI 1	Apoptosis , PERK , Autophagy
	4EGI-1, a competitive eIF4E/eIF4 g interaction inhibitor, binds to eIF4E(KD=25 μM).		Apoptosis , PERK , Autophagy
T14044	4E2RCat		PERK
	4E2RCat is an eIF4E-eIF4G interaction inhibitor (IC50: 13.5 μM).		PERK
T1742	4E1rcat		PERK , Autophagy
	4E1RCat is a dual inhibitor of eIF4E:eIF4 g and eIF4E:4E-BP1 interaction. And it inhibits the binding of eIF4 g to eIF4E with IC50 of 3.2 μM.		PERK , Autophagy
T14886	Cbz-B3A		mTOR
	Cbz-B3A is a potent inhibitor of mTORC1 signalling, inhibits phosphorylation of eIF4E-binding protein 1 (4EBP1) and blocks translation by 68%.		mTOR
T73582	EB1		MNK
	EB1 is a potent and selective MNK kinase inhibitor with inhibitory effects on MNK1 and MNK2 with IC50 values of 0.69 μM and 9.4 μM, respectively.EB1 inhibits the growth of cancer cells, promotes apoptosis, and inhibits t...		MNK
T3207	Briciclib	ON 014185	CDK , PERK , Autophagy
	Briciclib (ON 014185) is a small molecule that suppresses cyclin D1 accumulation in Y cells.		CDK , PERK , Autophagy
T3468	Tomivosertib	eFT508	MNK , PD-1/PD-L1
	Tomivosertib (eFT508) is a potent, highly selective MNK1 and MNK2 inhibitor with IC50 value of 1-2 nM.		MNK , PD-1/PD-L1
T37099	(Z)-4EGI-1
	(Z)-4EGI-1, the Z-isomer of 4EGI-1, serves as an inhibitor of both the eIF4E/eIF4G interaction and translation initiation. It effectively binds to eIF4E, exhibiting an IC50 of 43.5 μM and a Kd value of 8.74 μM. Notably, ...
T70124	Tomivosertib HCl
	Tomivosertib, also known as eFT508 is a MNK1/2 inhibitor. Tomivosertib binds to and inhibits the activity of MNK1 and 2. This prevents MNK1/2-mediated signaling, and inhibits the phosphorylation of certain regulatory pr...

Compounds

eIF4E-IN-1

T40211

Synonym: eIF4E-IN-1

Target:

eIF4E-IN-3

T40210

Synonym: eIF4E-IN-3

Target:

eIF4E-IN-2

T40214

Synonym: eIF4E-IN-2

Target: Apoptosis, PERK, Autophagy

Target: PERK, Autophagy

Target: CDK, PERK, Autophagy

Tomivosertib

T3468

Synonym: eFT508

Target: MNK, PD-1/PD-L1

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-00507	EIF4E Protein, Human, Recombinant	Human	E. coli
	Eukaryotic translation initiation factor 4E is a 217 amino acids protein that belongs to the eukaryotic initiation factor 4E family. eIF4F is a multi-subunit complex, the composition of which varies with external and int...
TMPJ-01109	EIF4EBP2 Protein, Human, Recombinant (His)	Human	E. coli
	Eukaryotic Translation Initiation Factor 4E-Binding Protein 2 (EIF4EBP2) is a member of the Eukaryotic Translation Initiation Factor 4E Binding Protein Family. EIF4EBP2 regulates eIF4E activity by preventing its assembly...
TMPY-01769	4EBP1 Protein, Human, Recombinant (His)	Human	E. coli
	The translational suppressor eIF4E binding protein-1, 4E-BP1 functions as a key regulator in cellular growth, differentiation, apoptosis and survival. The Eif4ebp1 gene, encoding 4E-BP1, is a direct target of a transcrip...
TMPH-02396	Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) Z Protein (His)	LASV	E. coli
	Plays a crucial role in virion assembly and budding. Expressed late in the virus life cycle, it acts as an inhibitor of viral transcription and RNA synthesis by interacting with the viral polymerase L. Presumably recruit...