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Simvastatin (MK 733) is an HMG-CoA reductase inhibitor (Ki=0.2 nM) with oral activity. Simvastatin has hypolipidemic activity, inhibits hepatic production of cholesterol, and is also used for the prevention of cardiovascular disease.

Simvastatin (Standard) is a reference standard for simvastatin, suitable for quantitative analysis, quality control, and related research in biochemical experiments. Simvastatin acts as an HMG-CoA reductase inhibitor (Ki = 0.2 nM), inhibiting cholesterol biosynthesis by blocking the production of mevalonate. As an orally effective lipid-lowering drug, Simvastatin is used for the treatment of hypercholesterolemia and the prevention of cardiovascular disease by reducing low-density lipoprotein (LDL) and triglyceride levels while increasing high-density lipoprotein (HDL) levels.