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4-Hydroxynonenal (4-HNE) (4-HNE) is an oxidative/nitrosative stress biomarker. It is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2).

4-Hydroxynonenal-D3 (Standard) is a reference standard of 4-Hydroxynonenal-D3 intended for quantitative analysis, quality control, and related biochemical research applications. 4-Hydroxynonenal-d3 is the deuterated form of 4-Hydroxynonenal (4-HNE), an α,β-unsaturated hydroxyalkenal and a biomarker of oxidative/nitrosative stress. This compound acts as both a substrate and inhibitor of ALDH2. It modulates numerous signaling pathways primarily through covalent adduct formation with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. Additionally, 4-Hydroxynonenalal plays a significant role in cancer through mitochondrial interactions.

4-Hydroxynonenal-D3 is the deuterated form of 4-Hydroxynonenal (T10148) (4-HNE), an α,β-unsaturated hydroxyalkenal and a biomarker of oxidative/nitrosative stress. This compound acts as both a substrate and inhibitor of ALDH2. It modulates numerous signaling pathways primarily through covalent adduct formation with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. Additionally, 4-Hydroxynonenalal plays a significant role in cancer through mitochondrial interactions.