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Doxazosin (UK 33274) is a long-acting α1-adrenoceptor inhibitor widely used to treat benign prostatic hyperplasia and lower urinary tract symptoms.

(R)-Doxazosin ((R)-UK 33274) is an isomer of Doxazosin, a selective oral a1-adrenoceptor agonist. Doxazosin is utilized for systemic antihypertensive and ocular hypotensive purposes. It achieves its antihypertensive effect by selectively blocking postsynaptic a1 receptors, reducing total peripheral resistance without impacting cardiac output. Doxazosin significantly lowers both standing and supine blood pressure.

Doxazosin-D8 is a deuterium labeled Doxazosin (T22316) (UK 33274).Doxazosin, a quinazoline derivative, selectively antagonizes postsynaptic AP1 adrenergic receptor.

Doxazosin HCl is the salt form of Doxazosin Free Base which acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation.

Doxazosin mesylate (UK 33274 mesylate)(UK 33274) is a quinazoline-derivative. It is a selectively antagonizes postsynaptic α1-adrenergic receptors.