7 octynoic acid

7-Octynoic acid (compound 42) serves as a PROTAC linker for synthesizing various PROTACs, composed of two distinct ligands joined by this linker, where one ligand interacts with an E3 ubiquitin ligase and the other binds to the target protein, leveraging the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

(Iso)-MS4322 ((Iso)-YS43-22) is a selective and potent protein arginine methyltransferase 5 (PRMT5) degrader with potential anticancer activity that effectively reduces PRMT5 protein levels in MCF-7 cells and inhibits the growth of a wide range of cancer cells.

FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional compound that selectively degrades the BET bromodomain transcriptional co-activator BRD4 by linking BET bromodomains to the E3 ubiquitin ligase CRBN. It also functions as a degrader of FKBP12F36V when FKBP12F36V is expressed in-frame with a targeted protein.

Boc-NH-PEG7-NH2 is a PEG-based PROTAC linker.

Boc-NH-PEG7-Tos (t-Boc-N-Amido-PEG7-Tos) is a PEG-based PROTAC linker that can be used in PROTAC synthesis.

Br-PEG7-Br is a PEG-based PROTAC linker utilized in PROTAC synthesis.

(S,R,S)-AHPC-PEG4-NH2 (VHL Ligand-Linker Conjugates 4) is a synthetic E3 ligase ligand-linker conjugate, consisting of a VHL ligand based on (S,R,S)-AHPC combined with a 4-unit PEG linker.

Amino-PEG7-acid, a PEG-based PROTAC linker, is utilized in PROTAC synthesis.

Bis-Tos-PEG7 is a PEG-based PROTAC linker used in PROTAC synthesis.

m-PEG7-alcohol (O-Methyl-heptaethylene glycol) is a PEG-based PROTAC linker. m-PEG7-alcohol can be used in the synthesis of PROTACs.

Fmoc-N-amido-PEG7-acid, a PEG-based PROTAC linker, is utilized in the synthesis of PROTACs.

m-PEG7-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Azido-PEG7-t-butyl ester is a PEG-based linker for PROTACs, facilitating the connection of two essential ligands and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

SNIPER(ABL)-044, a compound that links HG-7-85-01 (ABL inhibitor) to Bestatin (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels, achieving a DC50 value of 10 μM[1].

Bis-PEG7-PFP ester, a PEG-based linker for PROTACs, facilitates the selective degradation of proteins by connecting two essential ligands and utilizing the ubiquitin-proteasome system within cells.

Azido-PEG7-alcohol is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells (brackets).

Boc-NH-PEG7-azide is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, and enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

m-PEG6-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

Hydroxy-PEG7-Boc is a PEG-based linker for PROTACs, facilitating the connection of two essential ligands for PROTAC molecule formation and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

t-Boc-Aminooxy-PEG7-bromide is a polyethylene glycol (PEG)-based bifunctional linker used in synthesizing proteolysis targeting chimeras (PROTACs)[1].

m-PEG7-Tos is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules. This linker enhances selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

t-Boc-Aminooxy-PEG7-amine, a polyethylene glycol (PEG) derivative, serves as a PROTAC linker for synthesizing PROTACs [1].

Tos-PEG7-OH, a PEG-based linker for PROTACs, connects two essential ligands vital for the formation of PROTAC molecules, thereby facilitating selective protein degradation through the ubiquitin-proteasome system within cells.

PROTACSMARCA2 degrader-7 (Compound I-428) is a PROTAC degrader targeting the catalytic subunits SMARCA2 and SMARCA4 of the SWI SNF complex. In MV411, it achieves degradation of SMARCA2 and SMARCA4 with DC50 values of <100 nM and 100-500 nM, respectively.