5 ethynyl 2' deoxyuridine

5-Ethynyl-2'-deoxyuridine (EdU) is a nucleoside analog of thymidine used to monitor de novo DNA synthesis through click chemistry and serves as an alkyl chain-based PROTAC linker for synthesizing PROTACs.

dCeMM3 (2-(1H-benzimidazol-2-ylsulfanyl)-N-(5-chloropyridin-2-yl)acetamide) is a glue degrader. dCeMM3 prompts an interaction of CDK12-cyclin K with a CRL4B ligase complex, result in inducing ubiquitination and degradation of cyclin K.

5-Aminothalidomide is a E3 ligase ligand used in PROTAC technology.

Thalidomide-5-OH (2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione) is the Thalidomide-based cereblon ligand that used in the recruitment of CRBN protein. It can be connected to the ligand for protein by a linker to form PROTAC.

Thalidomide 5-fluoride (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-) is a thalidomide-based Cereblon ligand that binds to the IRAK4 protein ligand via a linker to form PROTACIRAK4 degrader-1.

CRBN ligand-9 (2-(2,6-dioxopiperidin-3-yl)-5-nitroisoindoline-1,3-dione) exhibit inhibition of CRBN.

(R)-CR8 trihydrochloride (CR8, (R)-Isomer trihydrochloride) is a CDK1 2 5 7 9 inhibitor that acts as a molecular glue degrader with neuroprotective activity and induces apoptosis.

(R)-CR8 ((R)-Isomer) is a potent and selective CDK inhibitor.

Azido-PEG5-alcohol, a non-cleavable 5 unit polyethylene glycol (PEG) ADC linker, finds application in the synthesis of antibody-drug conjugates (ADCs)[1]. Additionally, it serves as a PEG-based PROTAC linker for the synthesis of PROTACs[2].

m-PEG5-2-methylacrylate is a polyethylene glycol (PEG)- and alkyl ester-based PROTAC linker used in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

NH2-PEG5-OH is a polyethylene glycol (PEG)-based PROTAC linker, utilized for the synthesis of PROTACs[1]. It is a 5-unit PEG ADC linker that is non-cleavable, and employed in the synthesis of antibody-drug conjugates (ADCs)[2].

NH2-PEG3-C1-Boc, also known as PROTAC Linker 5, is a polyethylene glycol (PEG)-based linker utilized in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

VH032-PEG5-C6-Cl (HaloPROTAC 2) is a small molecule that includes the VH032-based VHL ligand and a 5-unit PEG linker, capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].

GNF5-amido-Me, the moiety based on GNF5 (ABL inhibitor),binds through a linker to the IAP ligand forming SNIPER[1].

Boc-C5-O-C5-O-C6-Cl (PROTAC Linker 2) is a chemical compound primarily used as a linker in PROTAC applications, facilitating the connection between a specific tyrosine kinase inhibitor (TKI) and the E3 recruiting ligand.

PROTAC SMARCA2 4-degrader-25 is a PROTAC that targets SMARCA2 4. It consists of the E3 ligase ligand (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, a PROTAC Linker (S)-2-Amino-3,3-dimethylbutanoic acid, and the target protein ligand SMARCA2 4-ligand-3. The conjugate of the E3 ubiquitin ligase ligand and Linker is (S,R,S)-AHPC.

Thalidomide 5-Pip-C-oxotetrahydropyrimidin-bromophenyl, an E3 Ligase Ligand-Linker Conjugate, serves as a precursor for synthesizing PROTAC GSPT1 degrader-2.

RNAse L RIBOTAC (compound C64) is an RNA-degrading chimera that binds to a four-way RNA helix called SL5 located in the 5’ UTR of the SARS-CoV-2 RNA genome, thereby inhibiting viral replication in pulmonary epithelial cancer cells.

PROTAC ER Degrader-14 (compound 86) is a PROTAC-type estrogen receptor ERR degrader. It comprises an E3 ubiquitin ligase ligand (blue part) (S)-Deoxy-thalidomide, a PROTAC linker (black part) N-Boc-piperazine, and a target protein ligand (red part) ER ligand-6. The combination of the E3 ligase and linker forms tert-Butyl (S)-4-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)piperazine-1-carboxylate.

RNA recruiter 1 is the RNA ligand segment of RNAse L RIBOTAC, an RNA degradation chimera capable of binding the four-stranded RNA helix SL5 in the 5' untranslated region of the SARS-CoV-2 RNA genome, thereby inhibiting viral replication in lung epithelial carcinoma cells. RNA recruiter 1 is useful for the synthesis of RIBOTAC.

RNA recruiter-linker 1 is part of the RNA ligand-linker in RNAse L RIBOTAC, which is an RNA-degrading chimera designed to bind the four-stranded RNA helix SL5 within the 5' untranslated region of the SARS-CoV-2 RNA genome. This binding inhibits the replication of the virus in lung epithelial carcinoma cells. RNA recruiter-linker 1 is also useful in RIBOTAC synthesis.

3-(5-Bromo-2-chlorophenyl)piperidine-2,6-dione is a ligand for CRBN-type E3 ubiquitin ligases and can be used in the synthesis of PROTACs (proteolysis-targeting chimeras).

PROTAC BRD4 Degrader-8 is a potent BRD4 inhibitor with IC50 values of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2, respectively, effectively degrading the BRD4 protein in PC3 prostate cancer cells[1].

PROTAC IDO1 Degrader-1, a pioneering compound, efficiently targets indoleamine 2,3-dioxygenase 1 (IDO1) for ubiquitination and degradation by recruiting IDO1 to the CRBN E3 ligase, thereby facilitating its entry into the ubiquitin-proteasome system (UPS) with a DC50 of 2.84 μM. This compound also moderately enhances the tumor-killing efficacy of HER2 CAR-T cells[1].