4'acetyl chrysomycin a

4'-Acetyl chrysomycin A is a bacterial metabolite and derivative of chrysomycin A that has been found inStreptomycesand has antibacterial and anticancer activities.1It is active against strains of methicillin-resistantS. aureus(MRSA) and vancomycin-resistant strains ofE. faecalisandE. faecium(MICs = 0.5-2 μg/ml for all). 4'-Acetyl chrysomycin A is cytotoxic against a panel of human cancer cell lines, including doxorubicin-sensitive or -resistant cells (IC50s = 0.085-0.26 and 3.4-16 ng/ml, respectively). 1.Wada, S.-I., Sawa, R., Iwanami, F., et al.Structures and biological activities of novel 4'-acetylated analogs of chrysomycins A and BJ. Antibiot. (Tokyo)70(11)1078-1082(2017)

4'-Acetyl-chrysomycin B, a 4'-acetylated analog of chrysomycin B, exhibits anti-Gram-positive bacterial and antimicrobial activities [1].

4'-Acetyl chrysomycin C is the 4'-acetylated analogue of Chrysomycin, which is a well-known antibiotic.

4'-Acetyl-chrysomycin B-alkene is an analog of chrysomycin B, exhibiting antibacterial activity.