2-hoba

2-Hydroxybenzylamine, a potent small molecule scavenger of IsoLGs, sequesters the reactive species as inert adducts. 2-Hydroxybenzylamine may be used to decrease early recurrence of atrial fibrillation and other atrial arrhythmias following atrial fibrillation ablation by decreasing IsoLG adducts with native biomolecules.

N-methyl-2-HOBA is a methylated form of the isoketal scavenger 2-HOBA .1It has low reactivity with isoketals and has no effect on hypertension induced by angiotensin II . N-methyl-2-HOBA has been used as a negative control for the activity of 2-HOBA in a mouse model of hypertension. 1.Kirabo, A., Fontana, V., de Faria, A.P.C., et al.DC isoketal-modified proteins activate T cells and promote hypertensionJ. Clin. Invest.124(10)4642-4656(2014)

5-methyl-2-HOBA is an isoketal scavenger. It reduces angiotensin II-induced increases in systolic blood pressure in mice.

4-Hydroxybenzylamine (4-HOBA) is a less reactive isomer of 2-HOBA as well as related compounds in a mouse model of hypertension.