2 aminopyridine

2-Aminopyridine is an amino-substituted pyridine heterocyclic compound, commonly found in fluorescent organic materials and therapeutic agents.

2,4-Dichloro-3-nitro-4-(N-ethoxycarbonyl)aminopyridine is a useful organic compound for research related to life sciences. The catalog number is TNU0895 and the CAS number is 947146-17-0.

N-Methyl-2-aminopyridine-3-carboxamide, with CAS No. 870997-87-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. N-Methyl-2-aminopyridine-3-carboxamide provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Methyl 2-aminoisonicotinate is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

GYKI 52466 is an allosteric AMPA receptor antagonist. It selectively inhibits AMPA-induced inward currents (IC50 = 7.5 µM) over NMDA- or GABA-induced inward currents in primary rat hippocampal neurons at 50 µM but also inhibits kainate-induced inward currents in the same cells (IC50 = 11 µM).2 GYKI 52466 (10 µM) reduces the amplitude of spontaneous excitatory postsynaptic currents (EPSCs) in the same cells. It increases the latency to seizure onset and reduces mortality in a rat model of generalized tonic-clonic seizures induced by 4-aminopyridine (4-AP) when administered at doses of 25 and 50 mg/kg. GYKI 52466 (30 mg/kg) prevents neuronal damage in the CA1 region of the hippocampus in a rat model of global ischemia-reperfusion injury induced by four-vessel occlusion.

6-Aminopicolinic acid is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.