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16hete

" in TargetMol Product Catalog
  • Inhibitors & Agonists
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(±)16-HETE
T35465128914-46-5
Electrolyte and fluid transport in the kidney are regulated in part by arachidonic acid and its metabolites. (±)16-HETE is the racemic version of a minor CYP450 metabolite of arachidonic acid released by the kidney upon angiotensin II stimulation. The biological activity of 16-HETE is stereospecific. 16(R)-HETE dose-dependently stimulates vasodilation of the rabbit kidney, however 16(S)-HETE does not affect perfusion pressure. At a concentration of 2 μM the (S)-enantiomer of 16-HETE inhibits proximal tubule ATPase activity by as much as 60%, whereas the (R)-isomer has negligible effects on ATPase activity.
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Cyclosporin A
Cyclosporine A, Cyclosporine, Ciclosporin
T094559865-13-3
Cyclosporin A is a naturally occurring cyclic polypeptide that is the active metabolite of a fungus. Cyclosporin A is an immunosuppressant that binds to procyclins and inhibits calcineurin (IC50=7 nM).
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Staurosporine
CGP 41251, Antibiotic AM-2282, AM-2282
T668062996-74-1
Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6 15 2 3 3000 nM) against PKC, PKA, c-Fgr, phosphorylase kinase and TAOK2. Staurosporine also induces apoptosis.
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TargetMol | Inhibitor Hot
Corticosterone
Kendall's compound B, Corticosterone (From plants), 17-Deoxycortisol, 11β,21-Dihydroxyprogesterone
T0948L50-22-6
Corticosterone (Kendall's compound B) is an adrenocortical steroid with salocorticoid and glucocorticoid activity that is orally active. Corticosterone is involved in the regulation of energy, immune responses, and stress responses in the body.
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TargetMol | Inhibitor Hot
Fludarabine
NSC 118218, Fludarabinum, F-ara-A
T103821679-14-1
Fludarabine (Fludarabinum) is a fluorinated purine analog, an inhibitor of nucleic acid synthesis and an inhibitor of STAT1 activation. Fludarabine has antitumor activity and can be used for the treatment of leukemia and lymphoma.
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TargetMol | Inhibitor Hot
Capsaicin
Zostrix, Qutenza, 8-Methyl-N-vanillyl-trans-6-nonenamide, (E)-Capsaicin
T1062404-86-4
Capsaicin ((E)-Capsaicin) is a natural product extracted from Capsicum annuum, and is a TRPV1 agonist (EC50=0.29 μM). Capsaicin has antitumor, anti-inflammatory, antioxidant and neuroprotective activities.
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TargetMol | Inhibitor Hot
gnf4877
T114472041073-22-5In house
GNF4877 is a potent inhibitor of DYRK1A and GSK3β (IC50s: 6 nM and 16 nM, respectively), resulting in the blockade of nuclear export of nuclear factor of activated T-cells (NFATc) and increased β-cell proliferation.
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TargetMol | Inhibitor Hot
Finerenone
BAY94-8862, BAY-94-8862, BAY-948862, BAY948862, BAY 94-8862, BAY 948862
T213951050477-31-0
Finerenone (BAY-948862) is a nonsteroidal antagonist of the mineralocorticoid receptor (MR) (IC50=18 nM) with selective and oral activity. Finerenone is used in the treatment of patients with chronic kidney disease with type 2 diabetes.
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TargetMol | Inhibitor Hot
PAF (C16)
C16-PAF
T2154774389-68-7In house
PAF (C16) is a potent MAPK and MEK ERK activator that induces increased vascular permeability. PAF (C16) (PAF (C16)) is a platelet-activating factor, a phospholipid-derived mediator and a ligand for PAF G protein-coupled receptor (PAFR). PAF (C16) has shown anti-apoptotic and anti-inflammatory activity in vitro, inhibiting Caspase-dependent apoptosis by interacting with its receptor (PAF-R) to perform cell signaling.
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6-8 weeks
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TargetMol | Inhibitor Hot
Astragaloside IV
AST-IV, AS-IV
T297384687-43-4
Astragaloside IV (AS-IV), an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1 2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells. Astragaloside IV is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine.1 It dose-dependently inhibits human adenovirus type 3 (HAdV-3) in A549 cells (IC50 = 23 μM; LC50 = 865 μM).It inhibits replication of HAdV-3 and decreases HAdV-3-induced apoptosis. It has diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. In particular, it reduces myocardial infarct size in dogs when administered prior to coronary ligation and reduces reperfusion arrhythmias in isolated rat hearts.
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TargetMol | Inhibitor Hot
Citronellol
dihydrogeraniol
T3240106-22-9
Citronellol ((±)-β-Citronellol) is used in insect repellents and perfumes and as a mite attractant.
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TargetMol | Inhibitor Hot
c16 ceramide
Palmitoyl Ceramide, N-Palmitoylsphingosine, N-acylsphingosine, C16 Ceramide (d18:1 16:0)
T3756224696-26-2
C16 Ceramide (Palmitoyl Ceramide) is a naturally occurring small molecule that activates p53 by directly and selectively binding to it.
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TargetMol | Inhibitor Hot
Bisindolylmaleimide I
Go 6850, GF109203X
T6513133052-90-1
Bisindolylmaleimide I (GF109203X) is a potent and highly selective protein kinase C (PKC) inhibitor, exhibiting a Ki of 14 nM.
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TargetMol | Inhibitor Hot
Zongertinib
BI 764532, BI 1810631
T695342728667-27-2In house
Zongertinib is a human HER2-selective tyrosine kinase inhibitor, a novel TK that is highly selective for covalent binding to the HER2 tyrosine kinase domain (TKD).Zongertinib exhibits antitumor activity with inhibitory effects on pHER2 and EGF.
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8-10 weeks
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TargetMol | Inhibitor Hot
740 Y-P acetate
PDGFR 740Y-P Acetate, 740YPDGFR acetate, 740 Y-P acetate(1236188-16-1 Free base)
TQ0003L1
740 Y-P acetate (740YPDGFR acetate) is a potent and cell-permeable PI3K activator.740 Y-P acetate tends to bind to GST fusion proteins containing the N- and C-terminal SH2 structural domains of p85, but not to GST alone.
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Asperphenamate
T1039063631-36-7In house
Asperphenamate is a fungal metabolite of Aspergillus flatiipes. The IC50s for T47D cells, MDA-MB-231 cells, and HL-60 cells are 92.3 μM, 96.5 μM, and 97.9 μM. Asperphenamate shows an anticancer effect.
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6-8 weeks
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CM-579
T10840L1846570-40-8In house
CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.
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6-8 weeks
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KRAS G12C inhibitor 16
T117702349392-79-4In house
KRAS G12C inhibitor 16 is a potent inhibitor of KRAS G12C.
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8-10 weeks
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RIPK1-IN-4
T127301481641-08-0In house
RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase).
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8-10 weeks
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TG 100572 Hydrochloride
T13156L867331-64-4In house
TG 100572 Hydrochloride is a inhibitor of multi-targeted kinase which inhibits receptor tyrosine kinases and Src kinases(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively).
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6-8 weeks
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TG 100801
TG100801, TG 100572
T13157867331-82-6In house
TG 100801 is a dual inhibitor of VEGFr2 and Src family (Src and YES) kinases and is a candidate compound for the treatment of age-related macular degeneration (AMD).
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7-10 days
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Sigma-LIGAND-1
T13510139652-01-0In house
Sigma-LIGAND-1 is a selective Sigma Receptor ligand with IC50 values of 16 nM and 19 nM at the DTG site and the PPP site, respectively, and a Ki of 4000 nM at the dopamine D2 receptor.
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6-8 weeks
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Tigemonam
T13926102507-71-1In house
Tigemonam is a monobactam, a novel orally administered monobactam that protects against gram-negative aerobic bacterial pathogens and is at least as active against clinical isolates of Enterobacteriaceae as amitraz or carmonan (MIC90: 0.06-16 mg l). [3]
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10-14 weeks
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Tazemetostat hydrobromide
E-7438 hydrobromide, EPZ-6438 hydrobromide
T170021467052-75-0In house
Tazemetostat hydrobromide (E-7438 hydrobromide) is a potent and selective EZH2 inhibitor. Tazemetostat hydrobromide inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 (Ki: 2.5 nM). Tazemetostat hydrobromide also inhibits EZH1 (IC50: 392 nM).
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