16,25dioacetylcucurbitacin f

16,25-Di-O-acetylcucurbitacin F is a natural product for research related to life sciences. The catalog number is TN5988 and the CAS number is 2062685-10-1.

Astragaloside IV (AS-IV), an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1 2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells. Astragaloside IV is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine.1 It dose-dependently inhibits human adenovirus type 3 (HAdV-3) in A549 cells (IC50 = 23 μM; LC50 = 865 μM).It inhibits replication of HAdV-3 and decreases HAdV-3-induced apoptosis. It has diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. In particular, it reduces myocardial infarct size in dogs when administered prior to coronary ligation and reduces reperfusion arrhythmias in isolated rat hearts.

1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo against skin inflammatory responses. 3. Ginkgetin is a good STAT3 inhibitor and may be a useful lead

Isopulegol has antioxidant, and neuroactive properties. It also has gastroprotective effects induced by isopulegol appear to be mediated, at least in part, by endogenous prostaglandins, K+ATP channel opening and antioxidant proprieties related to GSH incr

3,4-Dimethoxyphenylacetic acid (Homoveratrumic acid) is the papaverine intermediate, used to synthesis cardiovascular drugs.

D-(-)-Arabinose is a reducing sugar useful as a substrate in analysis of arabinose isomerases and synthesis of D-erythroascorbic acid in yeast. It shows strong growth inhibition against the Caenorhabditis elegans with an IC50 of 7.5 mM.

Benzyl benzoate (Benzoic acid benzyl ester) is one of the older preparations used for the therapy of scabies. Scabies is a skin infection caused by the Sarcoptes scabiei. Its symptoms are red spots, severe itching (particularly at night), and may lead to a secondary infection. Benzyl benzoate is useful in the therapy of scabies because it is lethal to this mite. It is also used for the therapy of lice affection of the body and head. Benzyl benzoate is not the therapy of choice for scabies because of its irritant properties.

DL-Mevalonolactone, a human endogenous metabolite, is the δ-lactone form of mevalonate, a precursor of the mevalonate pathway. It reduces mitochondrial membrane potential (∆Ψm), Ca2+ retention and NAD(P)H levels in the brain, and also induces mitochondrial swelling.DL-Mevalonolactone induces inflammation and oxidative stress, and reduces mitochondrial membrane potential.

Ethyl oleate, a fatty acid ester produced through the condensation of oleic acid and ethanol, serves as the liquid lipid component in nanostructured lipid carriers (NLCs). These NLCs represent a pioneering approach for the oral administration of trans-Ferulic acid (TFA), highlighting ethyl oleate's critical role in enabling effective drug delivery systems.

Pyruvic aldehyde (2-Oxopropanal) is a highly reactive dicarbonyl compound that can be converted to lactic acid by evolution from DHA and GLA.

Caryophyllene oxide is isolated from Aegle marmelos, with anti-inflammatory activity.

Methyl vanillate is Hovenia Dulcis Thunb extract and its ingredient methyl vanillate activate Wnt β-catenin pathway and increase bone mass in growing or ovariectomized mice. Methyl vanillate is considered to be a slightly soluble (in water) acidic compound. Methyl vanillate can be synthesized from vanillic acid. Methyl vanillate has been identified in foods such as cow's milk and beer.

Desaminotyrosine (3-(4-Hydroxyphenyl)propionic acid) is a microbially associated metabolite. Desaminotyrosine protects from influenza through augmentation of type I interferon signaling.

Emodin (Frangula emodin) is an 11β-HSD1 inhibitor with a selective IC50 of 186 and 86 nM against 11β-HSD1 in humans and mice, respectively. Emodin has antiviral, anti-inflammatory, and anti-cancer effects. Emodin can improve metabolic disorders in diet-induced obese mice.

2-Nonanone (Heptyl methyl ketone) is an endogenous metabolite, an antagonist of CYP1A2 (Potency = 35.6 μM), and is used as a flavor in the food industry.

Stigmasterol (Stigmasterin) is a phytosterol with major functions in the maintenance of cell membrane structure and physiology. Stigmasterol lowers cholesterol levels and has anti-tumor, anti-inflammatory, and immunomodulatory effects.

1. 2-Methoxycinnamic acid (o-Methoxycinnamic acid) can enhance inhibition of tyrosinase activity.

Cedrene (AI3-51328), a type sesquiterpene compound derived from Xylaria guizhouensis NJAU4742, promotes lateral root formation in plants and acts through growth hormone transport and signaling.

(-)-borneol (L-Borneol) has a highly efficacious positive modulating action at GABA receptor with an EC50 of 237 μM.

m-Anisaldehyde exhibits binding activity toward aldo-keto reductase family 1 member A1 and is widely used in biochemical experiments and drug synthesis research.

L-Leucine ((S)-Leucine) is one of nine essential amino acids in humans (provided by food), L-Leucine is important for protein synthesis and many metabolic functions. L-Leucine contributes to regulation of blood-sugar levels; growth and repair of muscle and bone tissue; growth hormone production; and wound healing. L-Leucine also prevents breakdown of muscle proteins after trauma or severe stress and may be beneficial for individuals with phenylketonuria. L-Leucine is available in many foods and deficiency is rare.

Elaidic acid (trans-Oleic Acid) is the 9-trans isomer of oleic acid. It is a monounsaturated trans-fatty acid which can be found in partially hydrogenated cooking oils. In human platelets incubated with arachidonic acid, elaidic acid inhibits HHT and HETE formation while inducing prostaglandin and thromboxane synthesis.

L-Pipecolic acid (L-Homoproline) is a breakdown product of lysine, accumulates in body fluids of infants with generalized genetic peroxisomal disorders, such as Zellweger syndrome, neonatal adrenoleukodystrophy.

D-Ribose(mixture of isomers) (D-(-)-Ribose), commonly referred to as simply ribose, is a five-carbon sugar found in all living cells. Ribose is not an essential nutrient because it can be synthesized by almost every tissue in the body from other substances, such as glucose. It is vital for life as a component of DNA, RNA, ATP, ADP, and AMP.