1-hydroxy ma 144 s1

Musettamycin is a potent inducer of erythroid differentiation in hemopoietic cells lines of rodent and human origin. It also has antimicrobial effects similar to the anthracycline class since it inhibits gram-positive bacteria and typically doesn't affect gram-negative bacteria.

UK-101 is a potent and selective inhibitor of the immunoproteasome LMP2, inhibiting β1i (LMP2), β1c (LMP2), and β5 (LMP2), with IC50s of 104 nM, 15 μM, and 1 μM, respectively. UK-101 exhibits a 144-fold and 10-fold higher affinity for β1i than for the distribution of β1c and β5 subunits. UK-101 induces apoptosis and can be used to study prostate cancer-related diseases.

Somatorelin (1-44) amide is a synthetic peptide that corresponds to the full 44-amino acid sequence of growth hormone-releasing hormone (GHRH), a hormone that stimulates the production of growth hormone from the pituitary gland and is involved in the regulation of cell proliferation and differentiation.1,2Somatorelin induces growth hormone release similarly to GHRHin vitroandin vivo.1

Anti-TSWV agent 1 is a highly effective inactivator (EC50:144 μg mL) of tomato spotted wilt virus (TSWV).

IDO1 2-IN-1 hydrochloride is the first potent dual inhibitor of IDO1 (IC50: 28 nM) and IDO2 (IC50: 144 nM) that is orally active.IDO1 2-IN-1 hydrochloride exhibits antitumor effects.

SEB Domain 144-153 acetate(210229-94-0 free base) is amino acid residues 163-172 of the staphylococcal enterotoxin B domain. SEB Domain 144-153 acetate(210229-94-0 free base) has been shown to inhibit the transcytosis of several staphylococcal enterotoxins, SEA, SEE, and TSST-1.

METTL1-WDR4-IN-1 (1) acts as an inhibitor of METTL1-WDR4, demonstrating an IC 50 value of 144 μM [1].

Antibacterial Agent 144 (compound 8e) exhibits superior efficacy against multi-resistant Staphylococcus aureus compared to Chloromycin and Amoxicillin. It acts by disrupting the bacterial cytoplasmic membrane and inhibiting biofilm formation. Additionally, it binds to human serum albumin (HSA) with a dissociation constant (Kd) of 13.2 μM, enhancing its bactericidal activity. This compound also forms a supramolecular complex with DNA, thereby hindering DNA replication [1].

SEB Domain 144-153 TFA is Staphylococcal Enterotoxin B domain amino acid residue 144-153. It inhibits transcytosis of multiple staphylococcal enterotoxins, SEE, SEA, and TSST-1.

Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-α converting enzyme (TACE) and matrix metalloproteinases (MMPs) and it also can potently inhibit the release of TNF-α in vitro, ex vivo, and in vivo with IC50s of 144 ng mL in vitro and 81.7 ng mL ex vivo, respectively[1].

HDAC6-IN-10 is a potent and specific HDAC6 inhibitor, exhibiting an IC50 value of 0.73 nM. It demonstrates remarkable selectivity towards HDAC6, with a selectivity range of 144 to 10,941-fold over other HDAC isoforms. Furthermore, HDAC6-IN-10 exhibits notable anti-proliferative effects on multiple myeloma cells [1].

SEB Domain (144-153) peptide is Staphylococcal Enterotoxin B domain amino acid residue 163-172. SEB Domain (144-153) has been shown to inhibit transcytosis of multiple staphylococcal enterotoxins, SEA, SEE, and TSST-1.

Crexavibart (BMS-986413; C-144-LS), an IgG1 λ2 antibody, specifically targets the receptor-binding domain of the SARS-CoV-2 spike (S) glycoprotein [1].

LEB-03-144 is a WEE1 DUBTAC (deubiquitinase-targeting chimera) linking AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 through a C3 alkyl linker. LEB-03-144 shows significant WEE1 stabilization in HEP3B hepatoma cancer cells [1] .

IDO1 2-IN-1 is the first potent, orally active dual IDO1 IDO2 inhibitor, exhibiting antitumor effects with IC50s of 28 nM and 144 nM for IDO1 and IDO2, respectively.

Antitumor agent-144 (16) functions as an anticancer compound, exhibiting IC 50 values of 2.6 μM in L1210 cells and 8.4 μM in KB cells, respectively [1].

Sulfamethizole-d4 is a deuterated compound of Sulfamethizole. Sulfamethizole has a CAS number of 144-82-1. Sulfamethizole is a sulfathiazole antibacterial reagent.

Compound 144 (also known as Anticancer Agent 144) is a potent inhibitor of both PTPN2 and PTP1B, exhibiting IC50 values of less than 2.5 nM, making it suitable for cancer research applications [1].

Agitoxin-2 TFA, a potent inhibitor of K+ channels, exhibits IC50 values of 201 pM and 144 pM for mK V 1.3 and mK V 1.1, respectively [1] [2].