1,2-dioleoyl-3-trimethylammonium-propane chloride

DOTAP chloride (1, 2-dioleoyl-3-trimethylammonium-propane chloride) is an efficient cationic lipid, and its target is mainly the negatively charged components on the cell membrane. DOTAP chloride binds to negatively charged nucleic acids (such as DNA and RNA) by electrostatic interaction to form complexes, thereby achieving the delivery of nucleic acids.

DOTAP mesylate is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

DOTAP methylsulfate is a cationic lipid reagent and a trimethylammonium cation derivative, with two octadecanoic fatty acid chains in its molecular structure, each containing one unsaturated alkene bond. DOTAP can self-assemble with negatively charged nucleic acids such as DNA via electrostatic interactions to form complexes, which enter cells through electrostatic adsorption and endocytosis. The hydrophobic domain of DOTAP promotes endosomal membrane fusion and facilitates nucleic acid release into the cytoplasm, thereby achieving efficient gene delivery. Currently, DOTAP methylsulfate is widely used in gene therapy, in vitro cell transfection, non-viral vector construction, and related research fields.