1,1,1-trifluoroethyl-peg-4-propargyl

1,1,1-Trifluoroethyl-PEG4-propargyl is a polyethylene glycol (PEG)-based linker used in the synthesis of PROTACs [1].

PROTAC BRD4 ligand-1, a component of Protac GNE-987, is a ligand for BRD4 and acts as an inhibitor of BET.

N-Boc-4-pentyne-1-amine is an alkyl chain-based PROTAC linker compound used in the synthesis of PROTAC MG-277 [1].

Succinic anhydride is a cyclic anhydride. Succinic anhydride acts as a nonclaevable ADC linker. Succinic anhydride can react with compound 4 to link the prodrug to an amine or hydroxy 1 group of a targeting polypeptide.

Thalidomide 4-fluoride (E3 ligase Ligand 4) (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand. Thalidomide 4-fluoride can be used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1.

Dasatinib carbaldehyde (PROTAC ABL binding moiety 4) is based on Dasatinib which is an ABL inhibitor, binds to the IAP ligand via a linker, and forms SNIPER [1].

Pomalidomide-PEG4-C2-NH2 hydrochloride is a PEG-based PROTAC linker used for synthesizing PROTACs[1].

Thalidomide-NH-C2-PEG3-OH (H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-) is an E3 ligase ligand-linker conjugate.

BET-IN-6, a ligand with potent and high affinity for inhibiting BRD2 BRD4, plays a crucial role in the synthesis of PROTAC BRD2 BRD4 degrader-1 [1], targeting the protein BRD2 4.

PROTAC BRD4 Degrader-1 is an efficacious degrader of BRD4(BRD4 BD1,IC50 of 41.8 nM).

PROTAC IRAK4 degrader-1 (compound I-210) is a Cereblon based PROTAC consisting of the PROTAC IRAK4 ligand-1, the E3 ligase ligand Pomalidomide and the PROTAC linker AM-Imidazole-PA-Boc.

PROTAC IRAK4 ligand-1 is a synthetic ligand targeting interleukin-1 receptor-associated kinase 4 (IRAK4).

PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a PROTAC coupler that targets SGK3 and binds ligand to VH032 VHL, inducing degradation of endogenous SGK3. It inhibits GDC0941-induced proliferation of cancer cells. [5017-88-83-4]

1-Isothiocyanato-PEG4-alcohol, a polyethylene glycol (PEG)-derived linker compound, is suitable for incorporation into Proteolysis Targeting Chimeras (PROTACs).

4-Bromobutylphosphonic acid is an alkyl chain-derived PROTAC linker used for the synthesis of PROTACs [1].

4-Maleimidobutyric acid, an alkyl chain-derived PROTAC linker, facilitates the synthesis of PROTACs[1].

Acid-PEG2-SS-PEG2-acid, a 4-unit PEG ADC linker with cleavable bonds, is used in the synthesis of antibody-drug conjugates (ADCs)[1].

Amino-PEG4-alcohol is a PEG-based PROTAC linker used for synthesizing PROTACs[1] and a non-cleavable 4-unit PEG ADC linker for synthesizing antibody-drug conjugates (ADCs)[2].

ARCC-4 is an enzalutamide-based von Hippel-Lindau (VHL)-recruiting AR PROTAC and outperforms enzalutamide and it is a low-nanomolar androgen receptor (AR) degrader based on PROTAC, with a DC50 of 5 nM. ARCC-4 effectively degrades clinically relevant AR mutants associated with antiandrogen therapy[1].

Azido-PEG4-4-nitrophenyl carbonate, a PEG-derived PROTAC linker, enables the synthesis of PROTACs[1].

Azido-PEG4-Val-Cit-PAB-OH is a 4-unit PEG ADC linker and a PEG-based PROTAC linker used in the synthesis of antibody-drug conjugates (ADCs)[1] and PROTACs[2].

Br-PEG4-C2-Boc is a cleavable 4-unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].

Bromoacetamido-PEG4-acid is a PEG-based PROTAC linker used for PROTAC synthesis[1] and serves as a cleavable 4-unit PEG ADC linker in the creation of antibody-drug conjugates (ADCs)[2].

Hydroxy-PEG4-acid, a non-cleavable 4-unit PEG ADC linker, is utilized in the synthesis of antibody-drug conjugates (ADCs) [1].