β3 ar agonist 2

β3-AR agonist 2 is a potent and selective agonist of β3-adrenergic receptor (β3-AR with an EC50 of 8 nM).

hA3AR agonist 2 is a potent activator of A3AR, with a Ki value of 3.5 nM.

Compound 19, a selective A3 Adenosine Receptor (A3AR) agonist (K i : 22.1 nM), effectively stimulates β-arrestin2 recruitment with an EC 50 value of 4.36 nM. This compound is utilized in research pertaining to inflammatory diseases, ischemia, cancer, neuropathic pain, liver diseases, and other chronic conditions [1].

D2R/D3R/5-HT1AR agonist 1 (compound 22b) is an orally active tri-target agonist with EC50 values of 1.29, 1.05, and 153.5 nM for D2R, D3R, and 5-HT1AR receptors, respectively. This compound improves MPTP-induced behavioral disorders and exhibits antidepressant properties, making it relevant for research in Parkinson's disease and depression.

Compound 9a (β2AR agonist 3) is a β2-adrenergic receptor (β2AR) agonist used in type 2 diabetes research [1].

Bopindolol is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol is a prodrug of pindolol and can be rapidly metabolized to an active hydrolyzed form. Bopindolol can be used for essential and renovascular hypertension research [1] [2].