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(1)
By Target- HIF
- HIF/HIF Prolyl-Hydroxylase(1)
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By Target By ResearchField- Cancer(1)
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Results for "
(rac)pt2399
" in TargetMol Product Catalog.- Inhibitors & Agonists1
- (Rac)-PT2399T126751672662-07-5(Rac)-PT2399 is a potent and specific inhibitor of hypoxia-inducible factor 2a (HIF-2α)(IC50 of 0.01 μM).
- $347
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Other Forms of Products
- PT2399
T12675L1672662-14-4PT2399 is a potent, selective, orally available HIF-2α antagonist that directly binds to the PAS B domain of HIF-2α (IC₅₀ = 6 nM). PT2399 exhibits antitumor activity. PT2399 specifically blocks the heterodimerization of HIF-2α and HIF-1β, thereby inhibiting the expression of downstream target genes such as VEGF and GLUT1, and exerts its antitumor effects.- $95
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