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SGK

Serine/threonine-protein kinases SGK represent a kinase subfamily with orthologs found across animal clades and in yeast (compare Treefam family TF320906). In most vertebrates, including humans, there are three isoforms encoded by the genes SGK1, SGK2, and SGK3. The name Serum/glucocorticoid-regulated kinase refers to the first cloning of a SGK family member from a cDNA library screen for genes upregulated by the glucocorticoid dexamethasone in a rat mammary epithelial tumor cell line. The first human family member (human SGK1) was cloned in a screen of hepatocellular genes regulated in response to cellular hydration or swelling.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T11181 EMD638683 R-Form 1184940-47-3 98%
EMD638683 R-Form
EMD638683 is a highly selective SGK1 inhibitor with IC50 of 3 μM. EMD638683 R-Form is the R-form of EMD638683.
T13847 PROTAC SGK3 degrader-1 2381320-35-8 98%
PROTAC SGK3 degrader-1
PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a PROTAC coupler that targets SGK3 and binds ligand to VH032 VHL, which induces degradation of endogenous SGK3.PROTAC SG...
T6057 URMC-099 1229582-33-5 99.32%
URMC-099
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
T14779 BRD7389 376382-11-5 99.17%
BRD7389
BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.
T2482 AT13148 1056901-62-2 99%
AT13148
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
T2622 GSK 650394 890842-28-1 98.93%
GSK 650394
GSK 650394 is a serum- and glucocorticoid-regulated kinase-1 inhibitor.
T9589 SI-113 1392816-46-4 98.81%
SI-113
SI-113 is a potent and selective inhibitor of SGK1, a serine/threonine protein kinase, that modulates several oncogenic signaling cascades.
T6635 EMD638683 1181770-72-8 98%
EMD638683
EMD638683,a novel SGK inhibitor with antihypertensive potency(with an IC50 of 3 μM).
T19913 CKI-7 1177141-67-1 100.00%
CKI-7
CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ...
T2356 Ro-3306 872573-93-8
Ro-3306
RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinases...
T9977 SGK1-IN-4 1628048-93-0 98%
SGK1-IN-4
SGK1-IN-4 is a selective inhibitor of SGK1 and can be used in studies about osteoarthritis.
EMD638683 R-Form
T11181
EMD638683 is a highly selective SGK1 inhibitor with IC50 of 3 μM. EMD638683 R-Form is the R-form of EMD638683.
PROTAC SGK3 degrader-1
T13847
PROTAC SGK3 degrader-1 (SGK3-PROTAC1) is a PROTAC coupler that targets SGK3 and binds ligand to VH032 VHL, which induces degradation of endogenous SGK3.PROTAC SG...
URMC-099
T6057
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
BRD7389
T14779
BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.
AT13148
T2482
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
GSK 650394
T2622
GSK 650394 is a serum- and glucocorticoid-regulated kinase-1 inhibitor.
SI-113
T9589
SI-113 is a potent and selective inhibitor of SGK1, a serine/threonine protein kinase, that modulates several oncogenic signaling cascades.
EMD638683
T6635
EMD638683,a novel SGK inhibitor with antihypertensive potency(with an IC50 of 3 μM).
CKI-7
T19913
CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ...
Ro-3306
T2356
RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinases...
SGK1-IN-4
T9977
SGK1-IN-4 is a selective inhibitor of SGK1 and can be used in studies about osteoarthritis.
TargetMol