SGK

Serine/threonine-protein kinases SGK represent a kinase subfamily with orthologs found across animal clades and in yeast (compare Treefam family TF320906). In most vertebrates, including humans, there are three isoforms encoded by the genes SGK1, SGK2, and SGK3. The name Serum/glucocorticoid-regulated kinase refers to the first cloning of a SGK family member from a cDNA library screen for genes upregulated by the glucocorticoid dexamethasone in a rat mammary epithelial tumor cell line. The first human family member (human SGK1) was cloned in a screen of hepatocellular genes regulated in response to cellular hydration or swelling.

Cat. No.	Product name	CAS No.	Purity
T11181	EMD638683 R-Form	1184940-47-3	98%
EMD638683 is a highly selective SGK1 inhibitor with IC50 of 3 μM. EMD638683 R-Form is the R-form of EMD638683.
T9977	SGK1-IN-4	1628048-93-0	98%
SGK1-IN-4 is a selective inhibitor of SGK1 and can be used in studies about osteoarthritis.
T19913	CKI-7	1177141-67-1	98%
CKI-7 2HCl is an inhibitor of casein kinase 1 (CK1).
T6635	EMD638683	1181770-72-8	98%
EMD638683,a novel SGK inhibitor with antihypertensive potency(with an IC50 of 3 μM).
T9589	SI-113	1392816-46-4	98%
SI-113 is a potent and selective inhibitor of SGK1, a serine/threonine protein kinase, that modulates several oncogenic signaling cascades.
T2622	GSK 650394	890842-28-1	98%
GSK650394 is a serum- and glucocorticoid-regulated kinase-1 inhibitor.
T2482	AT13148	1056901-62-2	98%
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
T14779	BRD7389	376382-11-5	98%
BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.
T6057	URMC-099	1229582-33-5	98%
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
T2356	Ro-3306	872573-93-8	98%
RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinases...

Cat. No.

Product name

CAS No.

Purity

Chemical Structure

T11181

EMD638683 R-Form

1184940-47-3

98%

EMD638683 is a highly selective SGK1 inhibitor with IC50 of 3 μM. EMD638683 R-Form is the R-form of EMD638683.

T9977

SGK1-IN-4

1628048-93-0

98%

SGK1-IN-4 is a selective inhibitor of SGK1 and can be used in studies about osteoarthritis.

T19913

CKI-7

1177141-67-1

98%

CKI-7 2HCl is an inhibitor of casein kinase 1 (CK1).

T6635

EMD638683

1181770-72-8

98%

EMD638683,a novel SGK inhibitor with antihypertensive potency(with an IC50 of 3 μM).

T9589

SI-113

1392816-46-4

98%

SI-113 is a potent and selective inhibitor of SGK1, a serine/threonine protein kinase, that modulates several oncogenic signaling cascades.

T2622

GSK 650394

890842-28-1

98%

GSK650394 is a serum- and glucocorticoid-regulated kinase-1 inhibitor.

T2482

AT13148

1056901-62-2

98%

AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.

T14779

BRD7389

376382-11-5

98%

BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.

T6057

URMC-099

1229582-33-5

98%

URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...

T2356

Ro-3306

872573-93-8

98%

RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinases...