Liver X Receptor

The liver X receptor (LXR) is a member of the nuclear receptor family of transcription factors and is closely related to nuclear receptors such as the PPARs, FXR and RXR. Liver X receptors (LXRs) are important regulators of cholesterol, fatty acid, and glucose homeostasis. LXRs were earlier classified as orphan nuclear receptors, however, upon discovery of endogenous oxysterols as ligands, they were subsequently deorphanized.Two isoforms of LXR have been identified and are referred to as LXRα and LXRβ.

Cat. No.	Product name	CAS No.	Purity
TN1719	Gymnestrogenin	19942-02-0	98%
TN1719	Gymnestrogenin has a dual LXRα±/α2 antagonistic profile.
T14679	XL041	1256918-39-4	98%
T14679	XL041 (BMS-852927) is an agonist of LXRβ-selective.
TN4016	Ethyl 2,4,6-trihydroxybenzoate	90536-74-6	98%
TN4016	Ethyl 2,4,6-trihydroxybenzoate is a dual-LXR modulator that regulates the expression of key genes in cholesterol homeostasis in multiple cells without inducing l...
TN5431	Icariside E4	126253-42-7	98%
TN5431	Icariside E4 is a natural compound derived from Ulmus minor that acts via AMPK phosphorylation and inhibition of MID1IP2 hypolipidation in HepG1 cells.Icariside ...
T6310	GW3965 hydrochloride	405911-17-3	99.75%
T6310	GW3965 hydrochloride (GW3965 HCl) is an effective and specific LXR agonist for hLXRα/β (EC50: 190/30 nM).
T63896	BE1218	2893967-40-1	99.7%
T63896	BE1218 is a liver X receptor (LXR) inverse agonist active on LXRα and LXRβ with an IC50 of 9 nM and 7 nM, respectively.
T5743	Gymnemagenin	22467-07-8	99.67%
T5743	Gymnemagenin is a potent and selective antagonist for the β isoform of LXR, it has antihyperglycemic activity.
T5128	RGX-104 hydrochloride	610318-03-1	99.49%
T5128	RGX-104 hydrochloride (SB742881) is a liver X receptor (LXR) agonist with potential immunomodulating and antineoplastic activities. It modulates innate immunity ...
T27478	GSK3987	264206-85-1	99.48%
T27478	GSK3987 is an LXR ligand. GSK3987 recruits the steroid receptor coactivator-1 to human LXRalpha and LXRbeta with EC50s of 40 nM.
T7768	RGX-104	610318-54-2	99.46%
T7768	RGX-104 (RGX-104 free Acid) free Acid is an agonist of potent liver-X nuclear hormone receptor (LXR)
T6690	T0901317	293754-55-9	99.43%
T6690	T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).
T5178	AZ876	898800-26-5	99.41%
T5178	AZ876 is a potent, highly selective LXR agonist with Ki/EC50 of 7/6 nM and 11/73 nM for hLXRα and hLXRβ respectively.
TQ0274	27-Hydroxycholesterol	20380-11-4	99.31%
TQ0274	27-Hydroxycholesterol (25(R)-27-hydroxy Cholesterol) is a selective modulator of estrogen receptor and an agonist of the liver X receptor.
T15427	GSK2033	1221277-90-2	99.05%
T15427	GSK2033 is an antagonist of LXR (pIC50s: 7 and 7.4 for LXRα or LXRβ, respectively).
T2768	Saikosaponin A	20736-09-8	98.76%
T2768	Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-b...
T2810	(20S)-Protopanaxatriol	34080-08-5	98.12%
T2810	(20S)-Protopanaxatriol (g-PPT)(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid re...
TN1055	Licochalcone E	864232-34-8	98.09%
TN1055	Licochalcone E is a potential LXRβ agonist.
T1783	LXR-623	875787-07-8	97.91%
T1783	LXR-623 (WAY 252623) is an orally bioavailable and highly specifical synthetic modulator of LXR.
TN2359	Iristectorigenin B	86849-77-6	98%
TN2359	Iristectorigenin B (Iristectrigenin B) is a potent hepatic X-receptor (LXR) modulator, a small molecule compound isolated from Belamcanda chinensis.Iristectrigen...
T1801	SR9243	1613028-81-1	98%
T1801	SR9243, an LXR inverse agonist, can induce LXR-corepressor interaction; shows anticancer activity and selectively targets the lipogenesis and Warburg effect.