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BACE

Beta-secretase 1 (BACE1), also known as beta-site amyloid precursor protein cleaving enzyme 1, beta-site APP cleaving enzyme 1, membrane-associated aspartic protease 2, memapsin-2, aspartyl protease 2, and ASP2, is an enzyme that in humans is encoded by the BACE1 gene. Expression of BACE1 is observed mainly in neurons.BACE1 is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells: in mice the expression of BACE1 is high in the postnatal stages, when myelination occurs.
Cat. No. Product name CAS No. Purity Chemical Structure
T10451 BACE1-IN-2 1352416-78-4 98%
BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).
T10453 BACE1-IN-5 2581114-83-0 98%
BACE1-IN-5 (Compound 15) is a β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC 50 of 9.1 nM. BACE1-IN-5 also inhibits cellular amy...
TN4399 Kushenol C 99119-73-0 98%
Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2)....
T14338 Atabecestat 1200493-78-2 98%
Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust an...
TQ0238 Lanabecestat 1383982-64-6 98%
Lanabecestat (AZD3293) is a highly permeable, orally active and blood-brain barrier penetrating BACE1 inhibitor (Ki: 0.4 nM).
T12429 PF-06751979 1818339-66-0 98%
PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).
T10452 BACE1-IN-4 2361157-92-6 98%
BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.
T8306 Epiberberine chloride 889665-86-5 98%
Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.07...
TN1434 Bavachromene 41743-38-8 98%
Bavachromene exhibits a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro.
T10450 BACE1-IN-1 1310347-50-2 98%
BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).
T10292 AM-6494 1874232-80-0 98%
AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).
TN1332 7-O-Methylaloeresin A 329361-25-3 98%
7-O-Methylaloeresin A shows significant antioxidant activity, it also has moderate inhibitory active on BACE.
TN4865 Putraflavone 23624-21-7 98%
Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging.
TN3410 Anatabine 581-49-7 98%
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
TN1472 Cassiaside 13709-03-0 98%
Cassiaside is a naphthyl ketone glycoside that inhibits BACE1 (IC50= 4.45 μM; Ki=9.85 μM).Cassiaside exhibits significant hepatoprotective effects against galact...
T13253 Umibecestat 1387560-01-1 98%
Umibecestat is an inhibitor of beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1), with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, r...
T3161L BACE-IN-1 acetate 98%
β-Secretase inhibitor has been used as β-site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) inhibitor in BACE1 inhibitor assay. β-Site amyloid precur...
T2639 LY2811376 1194044-20-6 98%
LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivity...
T4115 Auraptene 495-02-3 98%
Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7. It has anti-inflammatory, anti-carcinogenic, anti-bacterial, neuro...
TN2190 Scoulerine 6451-73-6 98%
Scoulerine shows significant cytotoxic effects against both two cancer cell lines (Caco-2 and Hep-G2 cancer cells), with IC50 values 6.44 ± 0.87 and 4.57 ± 0.42,...
BACE1-IN-2
T10451
BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).
BACE1-IN-5
T10453
BACE1-IN-5 (Compound 15) is a β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC 50 of 9.1 nM. BACE1-IN-5 also inhibits cellular amy...
Kushenol C
TN4399
Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2)....
Atabecestat
T14338
Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust an...
Lanabecestat
TQ0238
Lanabecestat (AZD3293) is a highly permeable, orally active and blood-brain barrier penetrating BACE1 inhibitor (Ki: 0.4 nM).
PF-06751979
T12429
PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).
BACE1-IN-4
T10452
BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.
Epiberberine chloride
T8306
Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.07...
Bavachromene
TN1434
Bavachromene exhibits a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro.
BACE1-IN-1
T10450
BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).
AM-6494
T10292
AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).
7-O-Methylaloeresin A
TN1332
7-O-Methylaloeresin A shows significant antioxidant activity, it also has moderate inhibitory active on BACE.
Putraflavone
TN4865
Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging.
Anatabine
TN3410
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
Cassiaside
TN1472
Cassiaside is a naphthyl ketone glycoside that inhibits BACE1 (IC50= 4.45 μM; Ki=9.85 μM).Cassiaside exhibits significant hepatoprotective effects against galact...
Umibecestat
T13253
Umibecestat is an inhibitor of beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1), with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, r...
BACE-IN-1 acetate
T3161L
β-Secretase inhibitor has been used as β-site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) inhibitor in BACE1 inhibitor assay. β-Site amyloid precur...
LY2811376
T2639
LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivity...
Auraptene
T4115
Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7. It has anti-inflammatory, anti-carcinogenic, anti-bacterial, neuro...
Scoulerine
TN2190
Scoulerine shows significant cytotoxic effects against both two cancer cell lines (Caco-2 and Hep-G2 cancer cells), with IC50 values 6.44 ± 0.87 and 4.57 ± 0.42,...
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