T10451 |
BACE1-IN-2
|
1352416-78-4
|
98%
|
|
BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).
|
T10453 |
BACE1-IN-5
|
2581114-83-0
|
98%
|
|
BACE1-IN-5 (Compound 15) is a β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC 50 of 9.1 nM. BACE1-IN-5 also inhibits cellular amy...
|
TN4399 |
Kushenol C
|
99119-73-0
|
98%
|
|
Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2)....
|
T14338 |
Atabecestat
|
1200493-78-2
|
98%
|
|
Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust an...
|
TQ0238 |
Lanabecestat
|
1383982-64-6
|
98%
|
|
Lanabecestat (AZD3293) is a highly permeable, orally active and blood-brain barrier penetrating BACE1 inhibitor (Ki: 0.4 nM).
|
T12429 |
PF-06751979
|
1818339-66-0
|
98%
|
|
PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).
|
T10452 |
BACE1-IN-4
|
2361157-92-6
|
98%
|
|
BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.
|
T8306 |
Epiberberine chloride
|
889665-86-5
|
98%
|
|
Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor (IC50s: 1.07...
|
TN1434 |
Bavachromene
|
41743-38-8
|
98%
|
|
Bavachromene exhibits a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro.
|
T10450 |
BACE1-IN-1
|
1310347-50-2
|
98%
|
|
BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).
|
T10292 |
AM-6494
|
1874232-80-0
|
98%
|
|
AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).
|
TN1332 |
7-O-Methylaloeresin A
|
329361-25-3
|
98%
|
|
7-O-Methylaloeresin A shows significant antioxidant activity, it also has moderate inhibitory active on BACE.
|
TN4865 |
Putraflavone
|
23624-21-7
|
98%
|
|
Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging.
|
TN3410 |
Anatabine
|
581-49-7
|
98%
|
|
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
|
TN1472 |
Cassiaside
|
13709-03-0
|
98%
|
|
Cassiaside is a naphthyl ketone glycoside that inhibits BACE1 (IC50= 4.45 μM; Ki=9.85 μM).Cassiaside exhibits significant hepatoprotective effects against galact...
|
T13253 |
Umibecestat
|
1387560-01-1
|
98%
|
|
Umibecestat is an inhibitor of beta-site amyloid precursor protein cleaving enzyme-1 (BACE-1), with IC50s of 11 nM and 10 nM for human BACE-1 and mouse BACE-1, r...
|
T3161L |
BACE-IN-1 acetate
|
|
98%
|
|
β-Secretase inhibitor has been used as β-site amyloid precursor protein (APP) cleaving enzyme-1 (BACE1) inhibitor in BACE1 inhibitor assay. β-Site amyloid precur...
|
T2639 |
LY2811376
|
1194044-20-6
|
98%
|
|
LY2811376, an orally available non-peptidic β-secretase(BACE1) inhibitor (IC50: 239-249 nM), can decrease Aβ secretion (EC50: 300 nM). It has 10-fold selectivity...
|
T4115 |
Auraptene
|
495-02-3
|
98%
|
|
Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7. It has anti-inflammatory, anti-carcinogenic, anti-bacterial, neuro...
|
TN2190 |
Scoulerine
|
6451-73-6
|
98%
|
|
Scoulerine shows significant cytotoxic effects against both two cancer cell lines (Caco-2 and Hep-G2 cancer cells), with IC50 values 6.44 ± 0.87 and 4.57 ± 0.42,...
|