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BACE

Beta-secretase 1 (BACE1), also known as beta-site amyloid precursor protein cleaving enzyme 1, beta-site APP cleaving enzyme 1, membrane-associated aspartic protease 2, memapsin-2, aspartyl protease 2, and ASP2, is an enzyme that in humans is encoded by the BACE1 gene. Expression of BACE1 is observed mainly in neurons.BACE1 is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells: in mice the expression of BACE1 is high in the postnatal stages, when myelination occurs.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TN2217 Sophoflavescenol 216450-65-6 99.65%
Sophoflavescenol
Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , the...
TN3410 Anatabine 581-49-7 98%
Anatabine
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
TN4865 Putraflavone 23624-21-7 98%
Putraflavone
Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging.
TN2131 Questin 3774-64-9 98%
Questin
Questin is an antimicrobial agent derived from Aspergillus florescens with an antimicrobial activity profile that inhibits V. harveyi, V. anguillarum, V. cholera...
TN1332 7-O-Methylaloeresin A 329361-25-3 98%
7-O-Methylaloeresin A
7-O-Methylaloeresin A shows significant antioxidant activity, it also has moderate inhibitory active on BACE.
T10292 AM-6494 1874232-80-0 98%
AM-6494
AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).
T10450 BACE1-IN-1 1310347-50-2 98%
BACE1-IN-1
BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).
TN1434 Bavachromene 41743-38-8 98%
Bavachromene
Bavachromene exhibits a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro.
T8306 Epiberberine chloride 889665-86-5 98%
Epiberberine chloride
Epiberberine chloride (Epiberberine (chloride)) is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BA...
T10452 BACE1-IN-4 2361157-92-6 98%
BACE1-IN-4
BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.
T12429 PF-06751979 1818339-66-0 98%
PF-06751979
PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).
TQ0238 Lanabecestat 1383982-64-6 98%
Lanabecestat
Lanabecestat (AZD3293) is a highly permeable, orally active and blood-brain barrier penetrating BACE1 inhibitor (Ki: 0.4 nM).
T14338 Atabecestat 1200493-78-2 98%
Atabecestat
Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust an...
TN4399 Kushenol C 99119-73-0 98%
Kushenol C
Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2)....
T10453 BACE1-IN-5 2581114-83-0 98%
BACE1-IN-5
BACE1-IN-5 (Compound 15) is a β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC 50 of 9.1 nM. BACE1-IN-5 also inhibits cellular amy...
T10451 BACE1-IN-2 1352416-78-4 98%
BACE1-IN-2
BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).
T6058 LY2886721 1262036-50-9 99.94%
LY2886721
LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease.
T6772 AZD3839 free base 1227163-84-9 99.93%
AZD3839 free base
AZD3839 free base is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.
T4398 LX2343 333745-53-2 99.92%
LX2343
LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343...
TN1343 8-Geranyloxypsoralen 7437-55-0 99.87%
8-Geranyloxypsoralen
8-Geranyloxypsoralen inhibits α2-secretase (BACE1) activity in non-competitive manner, with the IC(50) values <25.0 μM, it can induce vasorelaxation on rat arter...
Sophoflavescenol
TN2217
Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , the...
Anatabine
TN3410
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
Putraflavone
TN4865
Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging.
Questin
TN2131
Questin is an antimicrobial agent derived from Aspergillus florescens with an antimicrobial activity profile that inhibits V. harveyi, V. anguillarum, V. cholera...
7-O-Methylaloeresin A
TN1332
7-O-Methylaloeresin A shows significant antioxidant activity, it also has moderate inhibitory active on BACE.
AM-6494
T10292
AM-6494 is a potent and orally active BACE1 inhibitor (IC50: 0.4 nM) with in vivo selectivity over BACE2 (IC50: 18.6 nM).
BACE1-IN-1
T10450
BACE1-IN-1 is a high brain penetrant BACE1 inhibitor (IC50s: 32 and 47 nM for human BACE1 and BACE2).
Bavachromene
TN1434
Bavachromene exhibits a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro.
Epiberberine chloride
T8306
Epiberberine chloride (Epiberberine (chloride)) is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BA...
BACE1-IN-4
T10452
BACE1-IN-4 is a potent and highly selective BACE1 inhibitor (IC50: 3.8 nM; Ki: 1.9 nM), more selective at BACE1 over BACE2.
PF-06751979
T12429
PF-06751979 is an inhibitor of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) (IC50 of 7.3 nM in BACE1 binding assay).
Lanabecestat
TQ0238
Lanabecestat (AZD3293) is a highly permeable, orally active and blood-brain barrier penetrating BACE1 inhibitor (Ki: 0.4 nM).
Atabecestat
T14338
Atabecestat (JNJ-54861911) is a potent brain-penetrant and orally active β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, achieves robust an...
Kushenol C
TN4399
Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2)....
BACE1-IN-5
T10453
BACE1-IN-5 (Compound 15) is a β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC 50 of 9.1 nM. BACE1-IN-5 also inhibits cellular amy...
BACE1-IN-2
T10451
BACE1-IN-2 is a BACE1 inhibitor (IC50: 22 nM).
LY2886721
T6058
LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease.
AZD3839 free base
T6772
AZD3839 free base is a potent and selective BACE1 inhibitor with Ki of 26.1 nM, about 14-fold selectivity over BACE2. Phase 1.
LX2343
T4398
LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343...
8-Geranyloxypsoralen
TN1343
8-Geranyloxypsoralen inhibits α2-secretase (BACE1) activity in non-competitive manner, with the IC(50) values <25.0 μM, it can induce vasorelaxation on rat arter...
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TargetMol