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ATP Citrate Lyase

ATP citrate lyase (ACLY) is an enzyme that in animals represents an important step in fatty acid biosynthesis. By converting citrate to acetyl-CoA, the enzyme links carbohydrate metabolism, which yields citrate as an intermediate, with fatty acid biosynthesis, which consumes acetyl-CoA. In plants, ATP citrate lyase generates cytosolic acetyl-CoA precursors of thousands of specialized metabolites, including waxes, sterols, and polyketides.
Cat. No. Product name CAS No. Purity Chemical Structure
T11590 (-)-Hydroxycitric acid 27750-10-3 98%
(-)-Hydroxycitric acid (Garcinia acid) is the principal acid of fruit rinds of Garcinia cambogia. It is a potent and competitive inhibitor of ATP citrate lyase. ...
T5544 2-Furoic acid 88-14-2 98%
2-Furoic acid, an orally active selective human cathepsin K inhibitor, may have the therapeutic potential for the treatment of diseases characterized by excessiv...
T11589 Hydroxycitric acid tripotassium hydrate 6100-05-6 98%
Potassium citrate monohydrate effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation, and anti-tumor effects. Hydr...
T16861 SB 204990 154566-12-8 98%
SB 204990 is an effective and specific ATP citrate lyase enzyme inhibitor.
T7424 NDI-091143 2375840-87-0 98%
NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay),indirectly disrupting citrate binding vi...
T2337 BMS-303141 943962-47-8 98%
BMS-303141 is a potent ATP-citrate lyase (ACL) inhibitor (IC50: 0.13 uM, human recombinant ACL).
T22967 MEDICA16 87272-20-6 98%
MEDICA16 is a selective agonist for GPR40 as well as a partial agonist for GPR120. MEDICA16, an ATP-citrate lyase inhibitor, significantly reduces intracellular ...
T12045 (-)-Hydroxycitric acid lactone 27750-13-6 98%
Garcinia lactone is an anti-obesity agent.Garcinia lactone was a potent inhibitor of ATP citrate lyase, which catalyzes the extramitochondrial cleavage of citrat...
T3625 Bempedoic acid 738606-46-7 98%
ETC-1002, also known as ESP-55016 and Bempedoic acid, is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C...
(-)-Hydroxycitric acid
T11590
(-)-Hydroxycitric acid (Garcinia acid) is the principal acid of fruit rinds of Garcinia cambogia. It is a potent and competitive inhibitor of ATP citrate lyase. ...
2-Furoic acid
T5544
2-Furoic acid, an orally active selective human cathepsin K inhibitor, may have the therapeutic potential for the treatment of diseases characterized by excessiv...
Hydroxycitric acid tripotassium hydrate
T11589
Potassium citrate monohydrate effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation, and anti-tumor effects. Hydr...
SB 204990
T16861
SB 204990 is an effective and specific ATP citrate lyase enzyme inhibitor.
NDI-091143
T7424
NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay),indirectly disrupting citrate binding vi...
BMS-303141
T2337
BMS-303141 is a potent ATP-citrate lyase (ACL) inhibitor (IC50: 0.13 uM, human recombinant ACL).
MEDICA16
T22967
MEDICA16 is a selective agonist for GPR40 as well as a partial agonist for GPR120. MEDICA16, an ATP-citrate lyase inhibitor, significantly reduces intracellular ...
(-)-Hydroxycitric acid lactone
T12045
Garcinia lactone is an anti-obesity agent.Garcinia lactone was a potent inhibitor of ATP citrate lyase, which catalyzes the extramitochondrial cleavage of citrat...
Bempedoic acid
T3625
ETC-1002, also known as ESP-55016 and Bempedoic acid, is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C...