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ATP Citrate Lyase

ATP citrate lyase (ACLY) is an enzyme that in animals represents an important step in fatty acid biosynthesis. By converting citrate to acetyl-CoA, the enzyme links carbohydrate metabolism, which yields citrate as an intermediate, with fatty acid biosynthesis, which consumes acetyl-CoA. In plants, ATP citrate lyase generates cytosolic acetyl-CoA precursors of thousands of specialized metabolites, including waxes, sterols, and polyketides.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T79935 Forrestiacids J 2920898-66-2 98%
Forrestiacids J
Forrestiacid J is an inhibitor of ATP-citrate lyase (ACL), exhibiting an IC50 value of 2.6 μM [1].
T79936 Forrestiacids K 2920898-65-1 98%
Forrestiacids K
Forrestiacid K, a terpenoid derived from Pseudotsuga forrestii, functions as an inhibitor of ATP-citrate lyase (ACL) [1].
T12045 (-)-Hydroxycitric acid lactone 27750-13-6 99.91%
(-)-Hydroxycitric acid lactone
(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent.(-)-Hydroxycitric acid lactone was a potent inhibitor of ATP citrate lyase, which cata...
T3625 Bempedoic acid 738606-46-7 99.84%
Bempedoic acid
Bempedoic acid (ETC1002) is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects as...
T16861 SB 204990 154566-12-8 99.6%
SB 204990
SB 204990 is an effective and specific ATP citrate lyase enzyme inhibitor.
T22967 MEDICA16 87272-20-6 99.13%
MEDICA16
MEDICA16 is a selective agonist for GPR40 as well as a partial agonist for GPR120. MEDICA16, an ATP-citrate lyase inhibitor, significantly reduces intracellular ...
T7424 NDI-091143 2375840-87-0 98.61%
NDI-091143
NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay),indirectly disrupting citrate binding vi...
T11589 Hydroxycitric acid tripotassium hydrate 6100-05-6 95%
Hydroxycitric acid tripotassium hydrate
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-...
T5544 2-Furoic acid 88-14-2 100%
2-Furoic acid
2-Furoic acid (Furan-2-carboxylic acid) 2-Furoic acid can reduce serum cholesterol and triglyceride levels and has anti-lipidemic effects.
T2337 BMS-303141 943962-47-8
BMS-303141
BMS-303141 is a potent ATP-citrate lyase (ACL) inhibitor (IC50: 0.13 uM, human recombinant ACL).
T11590 (-)-Hydroxycitric acid 27750-10-3
(-)-Hydroxycitric acid
(-)-Hydroxycitric acid (Garcinia acid) (Garcinia acid) is the principal acid of fruit rinds of Garcinia cambogia. It is a potent and competitive inhibitor of ATP...
Forrestiacids J
T79935
Forrestiacid J is an inhibitor of ATP-citrate lyase (ACL), exhibiting an IC50 value of 2.6 μM [1].
Forrestiacids K
T79936
Forrestiacid K, a terpenoid derived from Pseudotsuga forrestii, functions as an inhibitor of ATP-citrate lyase (ACL) [1].
(-)-Hydroxycitric acid lactone
T12045
(-)-Hydroxycitric acid lactone (Garcinia lactone) is an anti-obesity agent.(-)-Hydroxycitric acid lactone was a potent inhibitor of ATP citrate lyase, which cata...
Bempedoic acid
T3625
Bempedoic acid (ETC1002) is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects as...
SB 204990
T16861
SB 204990 is an effective and specific ATP citrate lyase enzyme inhibitor.
MEDICA16
T22967
MEDICA16 is a selective agonist for GPR40 as well as a partial agonist for GPR120. MEDICA16, an ATP-citrate lyase inhibitor, significantly reduces intracellular ...
NDI-091143
T7424
NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay),indirectly disrupting citrate binding vi...
Hydroxycitric acid tripotassium hydrate
T11589
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-...
2-Furoic acid
T5544
2-Furoic acid (Furan-2-carboxylic acid) 2-Furoic acid can reduce serum cholesterol and triglyceride levels and has anti-lipidemic effects.
BMS-303141
T2337
BMS-303141 is a potent ATP-citrate lyase (ACL) inhibitor (IC50: 0.13 uM, human recombinant ACL).
(-)-Hydroxycitric acid
T11590
(-)-Hydroxycitric acid (Garcinia acid) (Garcinia acid) is the principal acid of fruit rinds of Garcinia cambogia. It is a potent and competitive inhibitor of ATP...
TargetMol