taste

Ethylhydrocupreine hydrochloride (Optochin hydrochloride) is a derivative of quinine with antimicrobial activity against Streptococcus pneumoniae and antimalarial activity with an IC50 of 25.75 nM against Plasmodium falciparum. It is also an agonist of Gallus gallus2 receptors (ggTas2r1, ggTas2r2, and ggTas2r7).

Aspartame (SC-18862), an artificial, non-carbohydrate sweetener, is aspartyl-phenylalanine-1-methyl ester.

Lactisole (na-PMP) is an inhibitor of the glucose-sensing receptor

Dutasteride (GI 198745) is a 5-alpha-reductase inhibitor that inhibits both type-1 and type2 isoforms of the enzyme and is used to treat benign prostatic hyperplasia.

5β-Dutasteride (5β, S-configuration of Dutasteride) is a potent inhibitor of both 5 alpha-reductase isozymes.

Dihydro Dutasteride, a metabolite of Dutasteride, effectively inhibits five α-reductase isozymes.

24-Epicastasterone (24-epi-Castasterone), a naturally occurring brassinosteroid, can be isolated from Hydrodictyon reticulatum [1].

Denatonium benzoate (THS-839) , a quaternary ammonium cation, is a compound of a salt with an inert anion like saccharide or benzoate. Its structure is involved in the local anesthetic lidocaine which difference only is the addition of a benzyl group to the amino nitrogen.

Neotame (HSDB 7965) is a white-colored, dipeptide methyl ester, which is found to be a highly potent and non-nutritive sweetener or flavour enhancer and hence finds applications in a variety of foods.

6-Methoxyflavanone (6-MeOF) is a positive allosteric modulator of the GABA response in human recombinant GABA A receptors, exhibiting antianxiety and anti-inflammatory properties, and is used to alleviate cisplatin-induced neuropathic pain.

Adenosine 5'-succinate is a compound closely related to adenosine monophosphate (AMP) that demonstrates strong inhibitory properties against taste receptor activation of transducin caused by Denatonium benzoate.

GIV3727, a bitter taste receptor hTAS2R antagonist, inhibits the activation of hTAS2R31 by saccharin and acesulfame potassium, effectively diminishing the bitter taste in foods, beverages, and pharmaceuticals [1].

S6821 is a TAS2R8 antagonist. S6821 was not found to be mutagenic or clastogenic in vitro, and did not induce micronuclei in bone marrow polychromatic erythrocytes in vivo.

Lysine-N,N-diacetic acid (BCML) is a highly efficient TAS2R4 inhibitor, blocking the human TAS2R4-mediated response to quinine.

Compound 28.1, also known as TAS2R14 agonist-2, is a potent and selective inhibitor of TAS2R14, exhibiting an EC50 of 72 nM [1].

FEMA 4774 (S9632) is a positive allosteric modulator of T1R2/T1R3. FEMA4774 shows obvious enhancement of the sweetness of sucrose in sensory evaluation tests

Alitame (hydrate) (Standard) is the standard substance of Alitame (hydrate), and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Alitame hydrate is a non-nutritive sweetener that is 2000 times sweeter than sucrose. It is formed from aspartic acid, alanine & an amide.

Dulcoside A, isolated from Stevia rebaudiana, is a sweetener with antioxidant activity.

Org 13011 has CNS activity and induces conditioned taste aversion by mediating 5-HT 1A receptors.

L-Gulose is an unnatural monosaccharide. L-Gulose is the putative furanose form of L-sorbosone that exists as a syrup with a sweet taste. It is an L-hexose sugar and an intermediate in the biosynthesis of L-Ascorbate (vitamin C).

Succinic acid (1, 2-ethanedicarboxylic acid) is a product of anaerobic metabolism and an intermediate of the tricarboxylic acid cycle.

Perillartine (DL-Perillartine) is a sweetener. Perillartine activates the taste receptor type 1 member 2 (Tas1r2) subunit in a species-dependent manner.

Octanoic acid (Caprylic acid), found naturally in coconuts and breast milk, is an oily liquid with a slightly unpleasant rancid taste and minimal solubility in water. It is commercially utilized in the production of esters for perfumery and in dye manufacturing.

δ-Decalactone is found in nonfat dry milks and fruits and with a sweet taste.