stat1

Signal Transducer and Activator of Transcription 1-Alpha Beta (STAT1) contains one SH2 domain and belongs to the transcription factor STAT family. When tyrosine- and serine-phosphorylated, STAT1 can form a homodimer termed IFN-gamma-activated factor (GAF), migrate into the nucleus and bind to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. STAT1 functions as signal transducer and transcription activator that mediates cellular responses to interferons. Defects in STAT1 are the cause of STAT1 deficiency complete and familial candidiasis type 7.

STAT1 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT1 can be activated by various ligands, including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. It is a signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG SCF and other cytokines and growth factors. The phosphorylated STATs dimerize, associate with ISGF3G IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon-stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. STAT1 becomes activated in response to KITLG SCF and KIT signaling and may mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Defects in STAT1 can cause STAT1 deficiency complete and familial candidiasis type 7.

Expression system: E. coli
Length: 24-166, Full Length of Mature Protein
Activity: Not Tested

Expression system: HEK293 Cells
Length: 27-192, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 27-192, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 1-558, Full Length
Activity: Not Tested

Expression system: P. pastoris (Yeast)
Length: 22-171, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 22-171, Full Length of Mature Protein
Activity: Not Tested

Expression system: HEK293 Cells
Length: 28-192, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 28-192, Full Length of Mature Protein
Activity: Not Tested

Expression system: P. pastoris (Yeast)
Length: 22-242, Extracellular Domain
Activity: Not Tested

Expression system: E. coli
Length: 19-499, Extracellular Domain
Activity: Not Tested

Expression system: P. pastoris (Yeast)
Length: 27-194, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 27-194, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 25-249, Partial
Activity: Not Tested

Expression system: E. coli
Length: 24-164, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 26-189, Partial
Activity: Cell Activity

Interferon‑alpha beta receptor 1 (IFN‑ alpha beta R1), also known as IFNAR1, are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. It interacts with STAT1 and STAT2, the interaction requires its phosphorylation at Tyr-466. It also interacts with FBXW11, the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex.

TNFSF18 is a single-pass type II membrane protein. It is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 cytokine binds to TNFRSF18 AITR GITR. It regulates T-cell responses, and functions as costimulator and lower the threshold for T-cell activation and T-cell proliferation. It is Important for interactions between activated T-lymphocytes and endothelial cells and Promotes leukocyte adhesion to endothelial cells. TNFSF18 mediates activation of NF-kappa-B. As Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. It also regulates migration of monocytes from the splenic reservoir to sites of inflammation.

Stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1 ERK2 and or MAPK3 ERK1. KITLG SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5.

Expression system: HEK293 Cells
Length: 1-323, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 19-144, Full Length of Mature Protein
Activity: ELISA

Expression system: HEK293 Cells
Length: 19-144, Full Length of Mature Protein
Activity: Not Tested

IL-9 is a pleiotropic cytokine that influences various distinct functions of different target cells such as T cells, B cells, mast cells and airway epithelial cells by activating STAT1, STAT3 and STAT5. Because of its pleiotropic functions, IL-9 has been demonstrated to be involved in several diseases, such as cancer, autoimmunity and other pathogen-mediated immune-regulated diseases. In this review, we focus on the role of Th9 and IL-9-producing cells in allergic asthma. IL-9 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 14.01 kDa and the accession number is A0A7N9IA33.