polypeptides

Amoxicillin (Amoxycillin) binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Amoxicillin Anhydrous is the anhydrous form of a broad-spectrum, semisynthetic aminopenicillin antibiotic with bactericidal activity. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis.

Amoxicillin trihydrate (Moxaline trihydrate) binds to and inactivates penicillin-binding protein (PBP) 1A located on the inner membrane of the bacterial cell wall. Amoxicillin trihydrate is a broad-spectrum, semisynthetic aminopenicillin antibiotic with bactericidal activity. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis.

Polymyxin B Sulfate (Poly-RX) is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B Sulfate (Poly-RX) is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic.

Bacitracin (Ziba-RX), a mixture of related cyclic polypeptides, disrupts bacteria by interfering with cell wall and peptidoglycan synthesis.

(-)-Epigallocatechin, the predominant flavonoid in green tea, possesses the unique ability to attach to unfolded native polypeptides, thereby inhibiting their transformation into amyloid fibrils.

Porcine pancreatic elastase is a serine protease composed of a single polypeptide chain with 240 amino acid residues. It has the ability to hydrolyze polypeptides and proteins, and can induce emphysema in hamsters.

Amoxicillin Sodium (Clavulanate) is a moderate- spectrum, bacteriolytic, β-lactam antibiotic.

Biotin NHS (NHS-Biotin) is an amino reactive biotin reagent used to prepare biotinylated surfaces or polypeptides.

Colistin A is an antibiotic generated by certain strains of the bacteria Paenibacillus polymyxa. Colistin is a mixture of the cyclic polypeptides colistin A and B and belongs to the class of polypeptide antibiotics known as polymyxins. Colistin is effecti

Estradiol 17-(β-D-glucuronide) (E217G) is an estrogen metabolite formed in the liver and subsequently excreted in bile.1It acts as a substrate of the multidrug resistance protein 2 (MRP2; Km= 75 μM), and through MRP2-mediated transport, functions as a cholestatic agent, decreasing bile flow.1,2In addition to binding to the MRP2 transport site, E217G has been shown to bind to an allosteric site that through positive cooperativity activates its own transportviaMRP2 and the transport of other MRP2 substrates, including the non-cholestatic estrogen metabolite, estradiol 3-(β-D-glucuronide) .2,3E217G has also been reported to be transported by MDR1, MRP1, MRP3, MRP4, MRP7, ABCG2 (a breast cancer resistance protein transporter), and the rat organic anion-transporting polypeptides 1-4.2 1.Loe, D.W., Almquist, K.C., Cole, S.P., et al.ATP-dependent 17β-estradiol 17-(β-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroidsThe Journal of Biological Chemisty271(16)9683-9689(1996) 2.Gerk, P.M., Li, W., and Vore, M.Estradiol 3-glucuronide is transported by the multidrug resistance-associated protein 2 but does not activate the allosteric site bound by estradiol 17-glucuronideDrug Metabolism and Disposition32(10)1139-1145(2004) 3.Gerk, P.M., Li, W., Megaraj, W., et al.Human multidrug resistance protein 2 transports the therapeutic bile salt tauroursodeoxycholateJournal of Pharmacology and Experimental Therapeutics320(2)893-899(2007)

Estrone sulfate sodium (17β-Estrone 3-sulfate) is an endogenous steroid and an estrogen ester that is biologically inactive. It is converted by steroid sulfatase into estrone . Estrone sulfate sodium has been investigated as a ligand for targeting organic anion transporting polypeptides f

Bacitracin complex is a bacitracin antibiotic complex composed of cyclic dipeptides that has been found inBacillus.1It is metal-dependent and is complexed to a divalent metal cation, such as Cu2+, Ni2+, Co2+, Zn2+, or Mn2+, for its activity.1,2Bacitracin complex is a mixture of bacitracin polypeptides in complex with copper. 1.Piacham, T., Isarankura-Na-Ayudhya, C., Nantasenamat, C., et al.Metalloantibiotic Mn(II)-bacitracin complex mimicking manganese superoxide dismutaseBiochem. Biophys. Res. Commun.341(4)925-930(2006) 2.Rodríguez-Uribe, N.A., Pérez-González, R., Domínguez-Mendoza, B.E., et al.Metallobacitracins: Affinity and structural study in aqueous solutionInorg. Chem. Commun.10461-70(2019)

VCP p97 inhibitor-1, a highly effective compound, inhibits VCP p97 (also known as Cdc48, CDC-48, or Ter94) with an IC 50 of 54.7 nM. This inhibitor induces a disruption in protein homeostasis and interferes with the degradation process of misfolded polypeptides by the ubiquitin-proteasome system (UPS).

Amoxicillin (trihydrate) mixed with potassium clavulanate (4:1) is a broad-spectrum antibiotic that exhibits strong oral absorption. It functions by inhibiting the biosynthesis of polypeptides in bacterial cell walls, which effectively halts cell growth, demonstrating its antimicrobial activity [1] [2] [3].

Monoamine oxidase, an enzyme comprising various polypeptides, catalyzes the oxidative deamination of diverse biological amines within both brain and peripheral tissues, yielding hydrogen peroxide in the process. This enzyme is crucial for regulating synaptic transmission, emotional behavior, and other cerebral functions [1] [2].

Carboxypeptidase A (EC 3.4.2.1), a zinc-containing metalloprotease, catalyzes the hydrolysis of peptide bonds near the C-terminal end of polypeptides and is frequently utilized in biochemical research. As a prototypical enzyme for metalloproteases, it is essential in biological systems [1].

Mal-PEG8-Val-Ala-PAB-Exatecan (Compound 9b), an antibody-drug conjugate linker (ADC linker), binds Nectin-4 polypeptides to chemotherapeutic agents for use in cancer research [1].

Antifreeze Polypeptide 6 (winter flounder) is one of the winter flounder's antifreeze polypeptides, which depresses the freezing point of plasma by inhibiting the expansion of ice nuclei [1].

Lamin fragment has a peptide sequence of Lys-Ala-Gly-Gln-Val-Val-Thr-Ile-Trp. Lamin polypeptides have an almost complete α-helical conformation with multiple α-helical domains separated by non-α-helical linkers that are highly conserved in length and amin

Lotus Tetragonolobus Lectin (LTL) Fluorescein is a plant lectin that functions as a probe by specifically binding to biomolecules, such as polysaccharides and polypeptides. It can serve as a biological material or organic compound useful in life sciences research.

Soybean Agglutinin (SBA) Biotinylated is a plant lectin that serves as a probe binding specifically to biomolecules, such as polysaccharides and polypeptides. It is utilized as a biomaterial or organic compound in life science research.

Peanut Agglutinin (PNA) Biotinylated is a plant lectin that serves as a probe for specifically binding to biomolecules such as polysaccharides and polypeptides. This compound is utilized as a biological material or organic compound in life science research.

Aleuria Aurantia Lectin (AAL), a plant lectin, functions as a probe for specific binding to biomolecules such as polysaccharides and polypeptides. It is useful as a biological material or organic compound in life science research.

Wheat Germ Agglutinin (WGA) is a plant lectin that serves as a probe with specific binding affinity for biomolecules such as polysaccharides and polypeptides. WGA can be utilized as a biomaterial or organic compound relevant to life science research.