lice

Abametapir (BRN 0123183), a metalloproteinase inhibitor, is able to target metalloproteinases critical to egg hatching and louse development.

D-Phenothrin ((-)-trans-Phenothrin) is a type II synthetic pyrethroid extensively employed in veterinary medicine for pest control on animals, crop protection, and the elimination of insects, mosquitoes, and human lice.

Azamethiphos, an organothiophosphate insecticide, is used in Atlantic salmon fish farming to control parasites.

Spliceostatin A is an anticancer agent and splicing inhibitor that inhibits the splicing mechanism of the spliceosome and inhibits mitotic clonal expansion and adipogenesis.Spliceostatin A induces cell cycle arrest in the G1 and G2/M phases, and induces apoptosis.

Mollicellin I (compound 1), a depsidone, exhibits minimal growth inhibitory activity against human breast cancer (Bre04), human lung (Lu04), and human neuroma (N04) cell lines, with GI50 values exceeding 10 μg/mL [1].

Mollicellin H, a secondary metabolite from the fungus C. brasiliense, exhibits an array of biological activities such as immunomodulation, cytotoxicity, and anti-tumor properties. It demonstrates growth inhibitory effects (GI 50 s) on various human cell lines, including breast cancer (Bre04) at 5.1 μg/mL, lung (Lu04) at 6.5 μg/mL, and neuroma (N04) at 2.5 μg/mL [1].

Glicetanile is an oral hypoglycemic compound that stimulates pancreatic β cells to secrete insulin, thereby effectively lowering blood sugar levels and showing potential efficacy in the treatment of type 2 diabetes.

Purified Siliceous Earth, used as a filtering aid for injections (also known as Purified Diatomaceous Earth, for injection; Purified Diatomaceous Silica, for injection), serves a key function in filtration processes.

Filicenol B is a natural product from Adiantum lunulatum.

Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50 = 650 nM). It inhibits multiple cancer cell lines via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome, displaying low-nM to sub-nM IC50s. Thailanstatin A, as a payload for ADCs, is conjugated to the lysines on trastuzumab, yielding linker-less ADC.

Elesclomol (STA-4783) is an oxidative stress inducer and a highly lipophilic copper ion carrier. Elesclomol induces apoptosis in tumor cells and is used in copper death related studies. Elesclomol also inhibits FDX1-mediated Fe-S cluster biosynthesis.

Malic enzyme inhibitor ME1 (ME1) is a specific inhibitor of Malic enzyme (IC50 = 0.15 μM). Malic enzyme inhibitor ME1 reduces cell viability/metabolic activity.

RPR104632 is a novel and potent antagonist located at the NMDA glycine site with neuroprotective activity.

Methyl 2,4-dihydroxyphenylacetate is a natural product isolated from Nigella damascena seeds with selective phytotoxic effects.

(E/Z)-TG003 is a potent and ATP-competitive inhibitor of Cdc2-like kinase (Clk).

Telaglenastat (CB 839) (IC50 of 24 nM), an effective, specific, and oral inhibitor, which is bioavailable glutaminase, for recombinant human GAC.

MC-Gly-Gly-Phe-Gly-Cyclobutanecarboxylic-Exatecan is an agent-linker conjugate designed for antibody-drug conjugate (ADC) applications, comprised of an ADC linker (MC-Gly-Gly-Phe-Gly-Cyclobutanecarboxylic acid) and the DNA topoisomerase I inhibitor, Exatecan. This conjugate is utilized in cancer research [1].

Garlic Extract is a derivative of garlic, containing the active component allicin. It holds promise in reducing the risk of cardiovascular diseases. Garlic Extract is effective in lowering total cholesterol and low-density lipoprotein (LDL) levels, while also improving high-density lipoprotein (HDL) levels.

(E/Z)-FK-506 26,28-Allylic ester rearrangement impurity (FK506-A) is an impurity found in Tacrolimus.

Benzyl benzoate (Benzoic acid benzyl ester) is one of the older preparations used for the therapy of scabies. Scabies is a skin infection caused by the Sarcoptes scabiei. Its symptoms are red spots, severe itching (particularly at night), and may lead to a secondary infection. Benzyl benzoate is useful in the therapy of scabies because it is lethal to this mite. It is also used for the therapy of lice affection of the body and head. Benzyl benzoate is not the therapy of choice for scabies because of its irritant properties.

Carbaryl (1-naphthyl methylcarbamate) is a carbamate insecticide and parasiticide. It is a potent anticholinesterase agent belonging to the carbamate group of reversible cholinesterase inhibitors. It has a particularly low toxicity from dermal absorption and is used for control of head lice in some countries.

Permethrin (NRDC-143) is a pyrethroid insecticide commonly used in the treatment of LICE INFESTATIONS and SCABIES.

Crufomate, an insecticide, is used extensively for the control of hornflies, cattle grubs and cattle lice.

Propetamphos, an organophosphate pesticide, can effectively control cockroaches, flies, mosquitoes, and other pests. It is also effective for cattle lice.