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Results for "

estrogen receptor modulator

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    56
    TargetMol | Inhibitors_Agonists
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    3
    TargetMol | Natural_Products
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Estrogen receptor modulator 1
T1524963676-22-2
Estrogen receptor modulator 1 causes regression of Tamoxifen-resistant, hormone-independent xenograft tumors. Estrogen receptor modulator 1 is an orally active and selective estrogen receptor modulator (SERM) (pIC50: 0.46).
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Estrogen receptor modulator 6
T40893787621-78-7
Estrogen receptor modulator 6 (compound 3a) is a highly specific and potent agonist of the estrogen receptor (ER) β, exhibiting remarkable affinity (K i = 0.44 nM) and impressive 19-fold selectivity for ERβ over ERα, as evidenced by its affinity (K i = 8.4 nM).
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Estrogen receptor modulator 7
T790642639168-13-9
Estrogen Receptor Modulator 7 is a potent modulator of estrogen receptors, utilized in cancer research [1].
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8-10 weeks
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Estrogen receptor modulator 8
T791092170766-56-8
Estrogen Receptor Modulator 8 (compound 4) is an orally active inhibitor targeting Estrogen Receptor ERR α with potent efficacy (IC50 = 0.437 nM in MCF-7 cells) and effectively hampers MCF-7 cell proliferation (IC50 = 0.1 nM) [1].
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8-10 weeks
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Estrogen receptor modulator 10
T824392991504-90-4
Compound G-5b, an estrogen receptor modulator 10, functions as an estrogen receptor (ER) antagonist (IC50=6.7 nM) and degrader (DC50=0.4 nM). It has the capability to induce apoptosis and block cells at the G1 G0 phase, making it applicable in cancer research [1].
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8-10 weeks
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Estrogen receptor modulator 11
T20556996719-63-0
Estrogen receptor modulator11 (Compound 27) is a tetrahydroisoquinoline derivative. It exhibits affinity for the estrogen receptor (ER), with IC50 values of 285 nM for ERα and 421 nM for ERβ. Estrogen receptor modulator11 does not demonstrate antagonist activity in MCF-7 cell assays.
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10-14 weeks
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4-Hydroxytamoxifen
trans-4-Hydroxytamoxifen, ICI 79280, (Z)-4-hydroxy Tamoxifen
T442068047-06-3
4-Hydroxytamoxifen (ICI 79280) is the active metabolite of Tamoxifen, an estrogen receptor modulator (SERM) with selective and oral potency. 4-Hydroxytamoxifen has antitumor activity and may be used in breast cancer research.
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TargetMol | Inhibitor Hot
Tamoxifen
Z-Tamoxifen, trans-Tamoxifen, ICI47699
T690610540-29-1
Tamoxifen (ICI47699) is a selective and orally effective estrogen receptor modulator (SERM). Tamoxifen has both inhibitory (e.g., mammary cells) and activating (e.g., bone, liver, and uterine cells) activity against estrogens.
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TargetMol | Inhibitor Hot
Pipendoxifene hydrochloride
T12482245124-69-0In house
Pipendoxifene hydrochloride is a selective modulator of estrogen receptor.
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6-8 weeks
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Fispemifene
HM-101, HM101, HM 101
T27322341524-89-8In house
Fispemifene (HM-101) is an estrogen receptor modulator (SERM) used to treat genitourinary syndromes and vaginal atrophy.
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6-8 weeks
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chf-4227
Chf4227, Chf 4227
T68042444643-64-5In house
CHF-4227 is a novel, potent and selective estrogen receptor modulator that reduces cholesterol and LDL cholesterol concentrations.
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Tamoxifen Citrate
Tamoxifen Z-isomer citrate, ICI 46474 Citrate
T083554965-24-1
Tamoxifen is an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM).
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Clomiphene citrate
NSC 35770, Clomifene citrate
T119350-41-9
Clomiphene citrate (NSC 35770) is a selective estrogen receptor modulator.
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Raloxifene hydrochloride
Raloxifene HCl, LY156758 hydrochloride, LY156758 (Keoxifene) HCl, LY139481 hydrochloride, Keoxifene hydrochloride
T154982640-04-8
Raloxifene hydrochloride (LY156758 hydrochloride) is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. It has estrogen agonist effects on bone and cholesterol metabolism but behaves as a complete estrogen antagonist on mammary gland and uterine tissue.
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Bazedoxifene acetate
WAY-TES 424, TSE 424, WAY-140424
T2544198481-33-3
Bazedoxifene acetate (WAY-TES 424) is a novel selective estrogen receptor modulator (SERM).
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Chlorotrianisene
tris(p-methoxyphenyl)chloroethylene, tri-p-anisylchloroethylene, TACE, CTA
T2569569-57-3
Chlorotrianisene (tri-p-anisylchloroethylene) is an orally bioavailable, highly lipophilic, synthetic triphenylethylene (TPE) derivative and selective estrogen receptor modulator (SERM), with predominantly estrogenic but also antiestrogenic activities.
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Calycosin
Cyclosin, 3'-Hydroxyformononetin
T392320575-57-9
Calycosin (Cyclosin) acts as a selective estrogen receptor modulator. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Calycosin suppresses breast cancer cell growth via ERβ-dependent regulation of IGF-1R, p38 MAPK and PI3K Akt pathways. Calycosin has antineoplastic effects against osteosarcoma through inducing apoptosis showing in vitro and in vivo investigations. Calycosin was shown to induce angiogenesis in human umbilical vein endothelial cell cultures (HUVEC) in vitro. Calycosin may be an effective skin-lightening agent that regulates the expression of melanogenic enzymes. Calycosin exhibited tyrosinase inhibitory activity with an IC(50) value of 38.4 microM.
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Bazedoxifene hydrochloride
TSE424 hydrochloride, WAY 140424 hydrochloride, TSE-424 hydrochloride, TSE 424 hydrochloride
T6404198480-56-7
Bazedoxifene hydrochloride (TSE 424 hydrochloride) is an orally active, selective, and potent estrogen receptor modulator (SERM) that crosses the blood-brain barrier and is an inhibitor of IL-6 GP130 protein interactions with high affinity for ERα and ERβ. It has a high affinity for ERα and ERβ and can be used to study postmenopausal osteoporosis and vasodilator-related diseases.
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Ospemifene
FC-1271a
T6620128607-22-7
Ospemifene (FC-1271a) is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. FDA approved on February 26, 2013.
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Toremifene
Z-Toremifene, GTx 006
T013989778-26-7
Toremifene (GTx 006) is a selective estrogen-receptor modulator (SERM).
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Arzoxifene hydrochloride
SERM 3, LY 353381 HCl
T10379182133-27-3
Arzoxifene hydrochloride is a selective estrogen receptor modulator that is a potent estrogen antagonist in mammary and uterine tissue.
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8-10 weeks
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Ospemifene D4
FC-1271a D4
T12329
Ospemifene D4 is a deuterium labeled Ospemifene. Ospemifene is a selective and orally active modulator of estrogen receptor.
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7-10 days
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Tamoxifen-​d5
trans-Tamoxifen-​d5, (Z)-Tamoxifen-​d5, ICI 47699-​d5
T13076157698-32-3
Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen is a selective modulator of estrogen receptor (SERM). Tamoxifen is a potent activator of Hsp90 and enhances the Hsp90 molecular chaperone ATPase activity.
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7-10 days
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Idoxifene
CB7432
T14883116057-75-1
Idoxifene is a tissue-specific selective estrogen receptor modulator.
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6-8 weeks
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