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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T83638 | IR820-PTX | Others | |
IR820-PTX is a nanoparticle composed of IR-820 and paclitaxel that is highly permeable and tumor-targeting.IR820-PTX can be used for near-infrared fluorescence imaging and tumor diagnostics.9-cis-Retinoic Acetylcholine (... | |||
T0070 | Pentoxifylline | Oxpentifylline,PTX,BL-191 | HIV Protease , PDE , Adenosine Receptor , Autophagy |
Pentoxifylline (PTX) modulates immunologic activity by stimulating cytokine production. Pentoxifylline is a methylxanthine derivative that inhibits phosphodiesterase and affects blood rheology. It also inhibits platelet ... | |||
T19699 | Triciribine phosphate | TCN-P,VD 002,VQD-002 | Apoptosis , Akt |
Triciribine phosphate (VD 002) is a highly selective AKT inhibitor that induces cell cycle arrest and cysteinyl asparagin-dependent apoptosis, inhibits neovascularization, and can be used in the study of leukemia. | |||
T16413 | OTX008 | Calixarene 0118,PTX008 | Galectin |
OTX008 (PTX008) is a selective galectin-1 inhibitor. | |||
T34056 | PhTX-343 TFA | (S)-PhTX 343,PhTX-343,(S)-PTX 343,(S)-Philanthotoxin 343,PhTX= 343 | |
PhTX-343, also known as Philanthotoxin 343, is synthetic analogue of Philanthotoxin 433. PhTX-343 blocks NMDA-gated ion channels; synthetic analog of the wasp polyamine amide toxin δ-philanthotoxin. | |||
T80042 | GpTx-1 | Sodium Channel | |
GpTx-1 exhibits potent selectivity as a NaV1.7 antagonist, demonstrating an inhibition concentration (IC50) of 10 nM [1]. | |||
T69976 | WS-691 | ||
WS-691 is a highly Potent and Orally Active ABCB1 Modulator. WS-691 significantly increased sensitization of ABCB1-overexpressed SW620/Ad300 cells to paclitaxel (PTX) (IC50 = 22.02 nM). WS-691 significantly increased the... | |||
T36896 | 6α-hydroxy Paclitaxel | 6alpha-hydroxypaclitaxel | Drug Metabolite |
6α-hydroxy Paclitaxel (6α-OH-PTX) is a major metabolite of the anticancer compound paclitaxel and is partially cytotoxic. | |||
T64016 | WS-898 | ||
WS-898 is a potent inhibitor of ABCB1 that reverses resistance to paclitaxel (PTX) in drug-resistant SW620/Ad300, KB-C2 and HEK293/ABCB1 cells with IC50 values of 5.0, 3.67 and 3.68 nM, respectively. | |||
T63267 | P-gp/BCRP-IN-1 | ||
P-gp/BCRP-IN-1 (compound 19) is a relatively safe, orally active, and efficient inhibitor of the efflux transporters P-gp and BCRP. By inhibiting their efflux function, it reverses resistance and enhances the oral bioava... | |||
T69162 | Ki23057 | ||
Ki23057 is a a FGFR2 inhibitor, which enhances the chemosensitivity of drug-resistant gastric cancer cell lines when used in combination with chemotherapeutic drugs. Ki23057 might be therapeutically promising for treatin... | |||
T72473 | NOD1/2 antagonist-1 | ||
NOD1/2 Antagonist-1 is a potent dual inhibitor of nucleotide-binding oligomerization domain-like receptors 1 and 2 (NOD1/2), displaying inhibitory concentrations (IC50) of 1.13 μM for NOD1 and 0.77 μM for NOD2. It exhibi... | |||
T37219 | N-Palmitoyl Glycine | ||
The acyl amides are a family of endogenous lipids that act as potent modulators of pain and inflammation. The best characterized members of this family are the arachidonoyl amides, which includes N-arachidonoyl ethanolam... |