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Search Result

Search Results for " non-alcoholic "

Targets

COX Epoxide Hydrolase

49

Compounds

3

Natural Products

5

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T12580 PTUPB COX , Epoxide Hydrolase
PTUPB is a potent and dual inhibitor of sEH and COX-2 enzymes(IC50 of 0.9 nM and 1.26 μM, respectively).
T27061 CP-24879 hydrochloride CP-24879 HCl Others
CP-24879 hydrochloride (CP-24879 HCl), a Δ5D/Δ6D dual-inhibitor, can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 hydrochloride exhibits superior antisteatotic an...
T2601 Vidofludimus SC12267,4sc-101 Dehydrogenase , DNA/RNA Synthesis , Interleukin
Vidofludimus (SC12267) (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).
T77099 Nimacimab JNJ 2463,RYI-018 Others
Nimacimab is a recombinant humanized monoclonal antibody. It can improve diabetes and non-alcoholic steatohepatitis.
T37184 CX08005 2-[(2-tetradecoxyphenyl)carbamoyl]benzoic acid Phosphatase
CX08005 is a protein tyrosine phosphatase 1B inhibitor. CX08005 reduces hepatic lipid accumulation and microcirculatory impairment associated with non-alcoholic fatty liver disease.
T14301 Apararenone MT-3995 Glucocorticoid Receptor
Apararenone (MT-3995) is a receptor antagonist of mineralocorticoid receptor which can be used to treat non-alcoholic steatohepatitis and diabetic nephropathy.
T65815 H-Asp(OtBu)-OtBu HCl Amino Acids and Derivatives
H-Asp(OtBu)-OtBu HCl is an aspartic acid derivative that may be used to study comparative neurological function and metabolic disorders of non-alcoholic hepatitis.
T9186 Ervogastat PF-06865571 Transferase
Ervogastat (PF-06865571) is a potent and well-tolerated diacylglycerol acyltransferase 2 inhibitor. Ervogastat reduces steatosis and hepatic triglyceride levels in non-alcoholic steatohepatitis (NASH).
T64334 Glycolithocholic acid, sodium salt Others
Glycolithocholic acid sodium salt, the sodium form of Glycolithocholic acid, is a glycine-conjugated secondary bile acid utilized in diagnosing ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH), and primary s...
T76700 Simtuzumab GS 6624,AB 0024 Monoamine Oxidase
Simtuzumab is a monoclonal antibody against lysyl oxidase-like protein 2 (LOXL2). Simtuzumab can be used to treat primary sclerosing cholangitis (PSC) and is not effective in patients with bridging fibrosis or compensato...
T67974 Berberine ursodeoxycholate HTD1801,BUDCA
Berberine ursodeoxycholate (HTD1801) is an orally effective hypolipidemic agent, an ionic salt of Berberine and Ursodeoxycholic acid.Berberine ursodeoxycholate has a wide range of metabolic activity and significantly red...
T77059 Leronlimab PRO 140 CCR
Leronlimab (PRO 140) is a humanized IgG4 anti-CCR5 monoclonal antibody. leronlimumab has both anti-HIV and anti-tumor activity, inhibiting CCR-mediated HIV-1 virus and cancer cell metastasis in mouse tumor models. Leronl...
T17236 Volixibat SHP626,LUM002 Others
Volixibat is a highly selective and competitive apical sodium-dependent bile acid transporter inhibitor. Volixibat has the potential for treatment for non-alcoholic steatohepatitis.
T11448 GOAT-IN-1 Others
GOAT-IN-1 is an inhibitor of ghrelin O-acyltransferase (GOAT), which could be useful for the prophylaxis or treatment of diabetes, hyperlipidemia, non-alcoholic fatty liver, Alzheimer’s disease, Parkinson’s disease, cere...
T35801 ML-262
ML-262 is an inhibitor of hepatic lipid droplet formation (IC50 = 6.4 nM in murine AML-12 cells), which is associated with non-alcoholic fatty liver disease. ML-262 does not induce cytotoxicity (up to 33 μM) or inhibit f...
T83421 1-Palmitoyl-sn-glycerol 3-phosphate 1-P-GPA
1-Palmitoyl-sn-glycerol 3-phosphate (1-P-GPA), an endogenous metabolite, is utilized in the research of non-alcoholic fatty liver disease [1].
T11661 INT-767 FXR , GPCR19
INT-767 is a potent farnesoid X receptor (FXR)/TGR5 dual agonist that prevents NASH and promotes visceral adipose brown lipogenesis and mitochondrial function for the study of non-alcoholic steatohepatitis.
T74421 Pemvidutide
Pemvidutide, a dual GLP-1R/GCGR agonist, significantly lowers body weight, liver fat, and serum lipids, holding promise for non-alcoholic steatohepatitis (NASH) and obesity research [1].
T62029 ML261
ML261 is a inhibitor of hepatic lipid droplets formation with an IC 50 of 69.7 nM. ML261 has research value in non-alcoholic fatty liver disease (NAFLD) and inflammation.
T81802 MGAT2-IN-4
MGAT2-IN-4 (compound 33) serves as a monoacylglycerol acyltransferase 2 (MGAT2) inhibitor, exhibiting liver metabolic stability. This compound is applicable in obesity, diabetes, and non-alcoholic steatohepatitis (NASH) ...
T35443 1-Palmitoyl-2-Stearoyl-3-Oleoyl-rac-glycerol
1-Palmitoyl-2-stearoyl-3-oleoyl-rac-glycerol is a triacylglycerol that contains palmitic , stearic , and oleic acid at the sn-1, sn-2, and sn-3 positions, respectively. It has been detected in RAW 264.7 cells by neutral ...
T78658 Pemvidutide TFA
Pemvidutide (TFA), a GLP-1R/GCGR dual agonist, effectively reduces body weight, liver fat, and serum lipid levels, and is utilized in research on non-alcoholic steatohepatitis (NASH) and obesity [1].
T35636 SHS4121705
SHS4121705 is an orally bioavailable mitochondrial uncoupler.1It increases oxygen consumption rate in L6 rat myoblast cells with an EC50value of 4.3 μM. SHS4121705 (25 mg/kg per day in the diet) reduces hepatic steatosis...
T21978 P-nitro-Pifithrin-α
p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α, a potent p53 inhibitor. It suppresses p53-mediated TGF-β1 expression in HK-2 cells and inhibits the activation of caspase-3 by Zika virus (ZIKV) strains. Mor...
T78093 Cisd2 agonist 1 Others
Cisd2 agonist 1 (Compound 4q), with an EC50 of 34 nM, augments Cisd2 expression and ameliorates pathological alterations in fatty liver disease, demonstrating good metabolic stability. This compound is utilized in non-al...
T79698 S217879
S217879 is a potent and selective activator of NRF2 that disrupts the KEAP1-NRF2 interaction, resulting in significant activation of the NRF2 pathway. This compound is applicable in research on non-alcoholic steatohepati...
T77175 Efruxifermin
Efruxifermin, an Fc-FGF21 fusion protein consisting of a human IgG1 Fc domain linked to modified human FGF21, exhibits a prolonged half-life and enhanced receptor affinity compared to its native counterpart. It is utiliz...
T74996 FXR agonist 3
FXR agonist 3, an anti-NASH (Non-Alcoholic Steatohepatitis) agent, functions by activating FXR. It demonstrates anti-fibrogenic activity by inhibiting the expression of COL1A1, TGF-β1, α-SMA, and TIMP1. Additionally, it ...
T63777 QH536
QH536 is an effective degrader of HMGCR (EC50: 0.22 μM).QH536 exhibits anti-inflammatory effects and does not have the side effect of inducing intracellular accumulation of cholesterol.QH536 can be used to study cardiova...
T62968 PPARα/δ agonist 1
PPARα/δ agonist 1 is a potent PPARα/PPARδ dual agonist with EC50 values of 7.0 nM for PPARα and 8.4 nM for PPARδ. PPARα/δ agonist 1 exhibits high selectivity for PPARγ (EC50: 1316.1 nM). agonist 1 has potential for non-a...
T72889 FXR agonist 4
FXR agonist 4 with an EC 50 value of 1.05 μM. FXR agonist 4 effectively improves hyperlipidemia, hepatic steatosis, insulin resistance and hepatic inflammation in DIO mice. FXR agonist 4 can be used for the research of ...
T63697 THR-β agonist 3
THR-β agonist 3 is a potent agonist of THR-β. THR-β agonist 3 has shown research potential for metabolic diseases such as obesity, hyperlipidemia, hypercholesterolemia, diabetes and other conditions such as steatosis and...
T62594 THR-β agonist 2
THR-β agonist 2 is a potent agonist of THR-β. THR-β agonist 2 has potential for studies of metabolic diseases (e.g. obesity, hyperlipidaemia, hypercholesterolaemia, diabetes and other conditions such as steatosis and non...
T10964L DB1976 dihydrochloride DB1976 hydrochloride,DB1976 2HCl Apoptosis , NF-κB
DB1976 dihydrochloride (DB1976 2HCl) , a transcription factor PU.1 inhibitor with potential anti-inflammatory activity, slowed down inflammation and fibrosis and improved glucose homeostasis and dyslipidemia in mice in i...
T63515 THR-β agonist 4
THR-β agonist 4 is a potent agonist of THR-β. THR-β agonist 4 has shown research potential for metabolic diseases such as hyperlipidemia, obesity, hypercholesterolemia, diabetes and other conditions such as steatosis and...
T78095 Demethyleneberberine chloride NF-κB
Demethyleneberberine chloride, a natural mitochondria-targeted antioxidant, mitigates colitis in mice and suppresses inflammatory responses by blocking the NF-κB pathway and modulating the equilibrium of Th cells. It is ...
T79733 NLRP3-IN-20 NOD-like Receptor (NLR)
NLRP3-IN-20 (compound 11) is an orally administered inhibitor targeting the NLRP3 inflammasome, exhibiting potent inhibition with an IC50 of 25 nM against IL-1β secretion. It possesses excellent pharmacokinetic propertie...
T79783 NSC 48160 Apoptosis
NSC 48160, a chemical compound, exhibits inhibitory effects on pancreatic cancer cell proliferation, with half-maximal inhibitory concentrations (IC50s) of 84.3 μM for CPFAC-1 and 94.5 μM for BxPC-3. It also promotes apo...
T62052 AMPK activator 6
AMPK activator 6 (Compound GC) activates the AMPK pathway and reduces lipid content in HepG2 and 3T3-L1 cells. AMPK activator 6 significantly suppresses the increase of total cholesterol (TC), low-density lipoprotein-C (...
T82254 GSK-LSD1 Histone Demethylase
GSK-LSD1, an LSD1 inhibitor, decreases food consumption and body weight while enhancing insulin sensitivity and glycemic regulation in murine obesity models. Additionally, it mitigates non-alcoholic fatty liver disease (...
T73414 EDP-305
EDP-305, an orally active, potent, and selective agonist of the farnesoid X receptor (FXR), exhibits EC50 values of 34 nM in chimeric FXR within CHO cells and 8 nM in full-length FXR in HEK cells. Demonstrating a potent ...
T64144 FXR antagonist 1
FXR antagonist 1 is a selective, orally active intestinal FXR antagonist with an IC50 value of 2.1 μM. FXR antagonist 1 antagonises intestinal FXR and selectively inhibits intestinal FXR signalling by feedback activation...
T82848 BMS-986172 Acyltransferase
BMS-986172 is an orally active, highly selective inhibitor of MGAT2, demonstrating inhibitory concentrations (IC50) of 4.6 nM for human MGAT2 (hMGAT2) and 20 nM for mouse MGAT2 (mMGAT2). It exhibits a half-life (T1/2) gr...
T35799 MBX-8025 (sodium salt)
MBX-8025 is an agonist of peroxisome proliferator-activated receptor δ (PPARδ).1 It is greater than 750- and 2,500-fold selective for PPARδ over PPARα and PPARγ. MBX-8025 (10 mg/kg per day for eight weeks) reduces increa...
T35816 ZLY032
ZLY032 is a dual agonist of free fatty acid receptor 1 (FFAR1/GPR40; EC50= 68 nM in a FLIPR assay) and peroxisome proliferator-activated receptor δ (PPARδ; EC50= 102 nM in a reporter assay).1It is selective for FFAR1 and...
T79358 PF-07247685 Endogenous Metabolite
PF-07247685, a potent BCKDC kinase (BDK) inhibitor (EC 50 = 2.2 nM), enhances the binding between BDK and the BCKDH E2 core subunit to block E1 phosphorylation. BDK regulation is crucial for BCKDH activity, which manages...
T35881 Resolvin E2
Resolvin E2 (RvE2) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acidviaan 18-HEPE intermediate, which is formed by aspirin-acetylated COX-2-...
T79357 PF-07238025 Endogenous Metabolite
PF-07238025, a potent branched-chain ketoacid dehydrogenase kinase (BDK) inhibitor with an EC50 of 19 nM, enhances the stability of the BDK-BCKDH core E2 subunit interaction and inhibits the phosphorylation of the E1 sub...
T37522 Teneligliptin
Teneligliptin (MP-513) is a potent chemotype prolylthiazolidine-based DPP-4 inhibitor, which competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50s of approximately 1 nM. Teneli...

Compounds

PTUPB
T12580
Synonym:
Target: COX, Epoxide Hydrolase
CP-24879 hydrochloride
T27061
Synonym: CP-24879 HCl
Target: Others
Vidofludimus
T2601
Synonym: SC12267,4sc-101
Target: Dehydrogenase, DNA/RNA Synthesis, Interleukin
Nimacimab
T77099
Synonym: JNJ 2463,RYI-018
Target: Others
CX08005
T37184
Synonym: 2-[(2-tetradecoxyphenyl)carbamoyl]benzoic acid
Target: Phosphatase
Apararenone
T14301
Synonym: MT-3995
Target: Glucocorticoid Receptor
H-Asp(OtBu)-OtBu HCl
T65815
Synonym:
Target: Amino Acids and Derivatives
Ervogastat
T9186
Synonym: PF-06865571
Target: Transferase
Glycolithocholic acid, sodium salt
T64334
Synonym:
Target: Others
Simtuzumab
T76700
Synonym: GS 6624,AB 0024
Target: Monoamine Oxidase
Berberine ursodeoxycholate
T67974
Synonym: HTD1801,BUDCA
Target:
Leronlimab
T77059
Synonym: PRO 140
Target: CCR
Volixibat
T17236
Synonym: SHP626,LUM002
Target: Others
GOAT-IN-1
T11448
Synonym:
Target: Others
ML-262
T35801
Synonym:
Target:
1-Palmitoyl-sn-glycerol 3-phosphate
T83421
Synonym: 1-P-GPA
Target:
INT-767
T11661
Synonym:
Target: FXR, GPCR19
Pemvidutide
T74421
Synonym:
Target:
ML261
T62029
Synonym:
Target:
MGAT2-IN-4
T81802
Synonym:
Target:
1-Palmitoyl-2-Stearoyl-3-Oleoyl-rac-glycerol
T35443
Synonym:
Target:
Pemvidutide TFA
T78658
Synonym:
Target:
SHS4121705
T35636
Synonym:
Target:
p-nitro-Pifithrin-α
T21978
Synonym:
Target:
Cisd2 agonist 1
T78093
Synonym:
Target: Others
S217879
T79698
Synonym:
Target:
Efruxifermin
T77175
Synonym:
Target:
FXR agonist 3
T74996
Synonym:
Target:
QH536
T63777
Synonym:
Target:
PPARα/δ agonist 1
T62968
Synonym:
Target:
FXR agonist 4
T72889
Synonym:
Target:
THR-β agonist 3
T63697
Synonym:
Target:
THR-β agonist 2
T62594
Synonym:
Target:
DB1976 dihydrochloride
T10964L
Synonym: DB1976 hydrochloride,DB1976 2HCl
Target: Apoptosis, NF-κB
THR-β agonist 4
T63515
Synonym:
Target:
Demethyleneberberine chloride
T78095
Synonym:
Target: NF-κB
NLRP3-IN-20
T79733
Synonym:
Target: NOD-like Receptor (NLR)
NSC 48160
T79783
Synonym:
Target: Apoptosis
AMPK activator 6
T62052
Synonym:
Target:
GSK-LSD1
T82254
Synonym:
Target: Histone Demethylase
EDP-305
T73414
Synonym:
Target:
FXR antagonist 1
T64144
Synonym:
Target:
BMS-986172
T82848
Synonym:
Target: Acyltransferase
MBX-8025 (sodium salt)
T35799
Synonym:
Target:
ZLY032
T35816
Synonym:
Target:
PF-07247685
T79358
Synonym:
Target: Endogenous Metabolite
Resolvin E2
T35881
Synonym:
Target:
PF-07238025
T79357
Synonym:
Target: Endogenous Metabolite
Teneligliptin
T37522
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T31964 Glycolithocholic acid Lithocholic acid glycine conjugate,Lithocholylglycine Others
Glycolithocholic acid (Lithocholic acid glycine conjugate) is a glycine conjugate of lithocholic acid.
T37526 2-Oleoylglycerol 2-Oleoyl Glycerol,2-OG,2-Monoolein GPR
2-Oleoylglycerol is a lipid found in palm kernel, sunflower seed and rice bran.2-Oleoylglycerol acts as a GPR119 agonist with neuroprotective effects and induces secretion of glucagon-like peptide 1 (GLP-1).2-Oleoylglyce...
T35624 Ajoene
Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities, including antibacterial, anticancer, antiplatelet, and antioxidant properties.1,2,3,4It is active against Gram-positive (MICs =...

Natural Products

Glycolithocholic acid
T31964
Synonym: Lithocholic acid glycine conjugate,Lithocholylglycine
Target: Others
2-Oleoylglycerol
T37526
Synonym: 2-Oleoyl Glycerol,2-OG,2-Monoolein
Target: GPR
Ajoene
T35624
Synonym:
Target:

Recombinant Proteins

Species：
Human (2)
Mouse (2)
Cynomolgus (1)
Expression System：
HEK293 (4)
E. coli (1)
Tag：
N-His (2)
N-hFc (2)
His (1)
Cat No. Product Name Species Expression System
TMPK-01196 CCL24 Protein, Mouse, Recombinant (His) Mouse HEK293
C-C motif chemokine ligand 24 (CCL24) is a chemokine that regulates inflammatory and fibrotic activities through its receptor, C-C motif chemokine receptor (CCR3). CCL24 is a chemokine that regulates inflammation and fib...
TMPK-01265 CCL24 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
C-C motif chemokine ligand 24 (CCL24) is a chemokine that regulates inflammatory and fibrotic activities through its receptor, C-C motif chemokine receptor (CCR3). CCL24 is a chemokine that regulates inflammation and fib...
TMPK-01195 CCL24 Protein, Mouse, Recombinant (hFc) Mouse HEK293
C-C motif chemokine ligand 24 (CCL24) is a chemokine that regulates inflammatory and fibrotic activities through its receptor, C-C motif chemokine receptor (CCR3). CCL24 is a chemokine that regulates inflammation and fib...
TMPK-00704 CCL24 Protein, Human, Recombinant (hFc) Human HEK293
C-C motif chemokine ligand 24 (CCL24) is a chemokine that regulates inflammatory and fibrotic activities through its receptor, C-C motif chemokine receptor (CCR3). CCL24 is a chemokine that regulates inflammation and fib...
TMPY-06821 THRB Protein, Human, Recombinant (His) Human E. coli
Thyroid hormone receptor beta (THRB), also known as TRbeta and NR1A2, belongs to the nuclear hormone receptor family. Featuring an N-terminal transactivation domain, a central DNA-binding domain, and a hormone/ligand-bin...
Cat No. Product Name
L2193 Anti-Liver Cancer Compound Library

1787 compounds
1787 species of compounds related to liver cancer that can be used in anti-liver cancer drug development and pharmacological studies.

Libraries

Anti-Liver Cancer Compound Library
L2193
Compounds: 1787
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