NH2 PEG3

NH2-PEG3 (PROTAC Linker 35) is a polyethylene glycol (PEG) linker used in the synthesis of PROTAC (β-NF-JQ1)[1].

Ald-Ph-amido-PEG3-C2-NH2 is a PEG-based PROTAC linker used in PROTAC synthesis [1].

Biotin-PEG3-(CH2)3-NH2 TFA salt is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Boc-Aminooxy-PEG3-C2-NH2, a polyethylene glycol (PEG) derived linker, is utilized in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

NH2-PEG3-C1-Boc, also known as PROTAC Linker 5, is a polyethylene glycol (PEG)-based linker utilized in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

BCN-exo-PEG3-NH2 is a PEG-based PROTAC linker used in PROTAC synthesis[1].

Pomalidomide-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.

Pomalidomide-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 5) is a synthesized E3 ligase ligand-linker conjugate incorporating the Pomalidomide based cereblon ligand and 3-unit PEG linker.

Thalidomide-O-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 3) is an E3 ligase ligand-linker conjugate developed using a Thalidomide-based cereblon ligand and a 3-unit PEG linker, synthesized specifically for use in PROTAC technology.

(S,R,S)-AHPC-PEG3-NH2 hydrochloride (E3 ligase Ligand-Linker Conjugates 5) is an E3 ligase ligand-linker conjugate that integrates the (S,R,S)-AHPC-based VHL ligand with a 3-unit PEG linker.

(S,R,S)-AHPC-PEG3-NH2 is a synthetic conjugate composed of the (S,R,S)-AHPC VHL ligand and a 3-unit PEG linker, utilized in PROTAC technology as an E3 ligase ligand-linker.

endo-BCN-PEG3-NH2 is a PEG-based linker used in PROTACs (proteolysis targeting chimeras) that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Fmoc-NH-PEG3-C2-NH2 is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands crucial for PROTAC molecule formation. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

NH2-C5-PEG4-N3-L-Lysine-PEG3-N3 is a seven-unit cleavable polyethylene glycol (PEG) antibody-drug conjugate (ADC) linker used in ADC synthesis[1].

Pomalidomide-amido-PEG3-C2-NH2, known as Cereblon Ligand-Linker Conjugates 22, is a synthesized E3 ligase ligand-linker conjugate designed for use in PROTAC technology. It consists of the Pomalidomide-based cereblon ligand and a 3-unit PEG linker. [1]

Bis-NH2-C1-PEG3 (PROTAC Linker 24) is a polyethylene glycol (PEG)-based linker used in synthesizing PROTACs, aiding in the targeted degradation of specific proteins [1].

Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate, incorporates a cereblon ligand derived from Thalidomide and a 3-unit PEG linker. This compound is specifically designed for use in PROTAC technology, which utilizes small molecules to induce protein degradation [1].

Amino-PEG3-t-butyl ester is a PEG derivative containing an amino group with the t-butyl protected carboxyl group. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

YT 6-2-PEG3-C2-NH2 is a conjugate of the autophagy-targeting ligand (ATL) targeting p62 SQSTM1 and an AUTOTAC linker. It is used in the synthesis of the AUTOTAC degrader ATC-324 for the androgen receptor (AR). ATC-324 induces the formation of the AR p62 complex, leading to autophagy-lysosomal degradation of AR. This action reduces nuclear AR levels and downregulates target gene expression of AR and AR-v7, effectively degrading common AR mutants found in prostate cancer (PCa).

L321-NH-C3-PEG3-C1-NH2 is a conjugation of the E3 ligase ligand and linker found in BRD4 PROTAC L134.

Azido-C1-PEG3-C3-NH2 is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands necessary for PROTAC molecule formation, and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

NH2-PEG3-C6-Cl, a PEG-based linker for PROTACs, connects two essential ligands critical for forming PROTAC molecules. This linker facilitates selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

Thalidomide-O-amido-C3-PEG3-C1-NH2 is a synthesized conjugate compound serving as an E3 ligase ligand-linker, featuring a cereblon ligand based on Thalidomide and a 3-unit PEG linker, specifically designed for use in PROTAC technology.

N-Boc-C1-PEG3-C3-NH2 is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.