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  • Monoamine Transporter
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Monoamine Transporter

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    35
    TargetMol | Inhibitors_Agonists
  • Dye Reagents
    3
    TargetMol | Dye_Reagents
  • Natural Products
    5
    TargetMol | Natural_Products
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    TargetMol | Disease_Modeling_Products
Fostamatinib
R788
T6115901119-35-5
Fostamatinib (R788)(IC50 of 41 nM), which is a prodrug of the active metabolite R406, is a Syk inhibitor. It does not work on Lyn.
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Diclofensine
Ro 8-4650
T734167165-56-4In house
Diclofensine (Ro 8-4650) is a monoamine reuptake inhibitor that blocks dopamine (IC50=0.74 nM), norepinephrine (IC50=2.3 nM), and 5-hydroxytryptophan (IC50=3.7 nM) in synaptosomes of the rat brain. dAURK-4 hydrochloride is an inhibitor of dopamine (IC50=0.74 nM), norepinephrine (IC50=2.3 nM) and 5-hydroxytryptophan (IC50=3.7 nM).
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4-6 weeks
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Reserpine
Serpivite, Serpasil, Serpalan
T079150-55-5
Reserpine (Serpalan) is an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
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VMAT2-IN-2 tosylate
T790612608770-12-1
VMAT2-IN-2 tosylate is a potent inhibitor of VMAT2, applicable in tardive dyskinesia research [1].
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8-10 weeks
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3,4-Dihydroxypyrovalerone HCl
3,4-Methylenedioxy pyrovalerone metabolite 2 HCl, 3,4-MDPV metabolite 2 HCl, 3,4-hydroxy-α-Pyrrolidinopentiophenone HCl
T2032662748289-38-3
3,4-Dihydroxypyrovalerone HCl is an analog of Pyrovalerone. Pyrovalerone inhibits the dopamine transporter (DAT), serotonin transporter (SERT), and norepinephrine transporter (NET).
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FFN 206 dihydrochloride
T411951883548-88-6In house
FFN 206 dihydrochloride is a fluorescent VMAT2 substrate that can be used to detect VMAT2 subcellular sites in cell culture and shows no detectable inhibition of DAT.
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Tetrabenazine
Xenazine, Ro 1-9569
T071958-46-8
Tetrabenazine (Ro 1-9569) is a former antipsychotic drug used to treat various movement disorders. It inhibits neurotransmitter uptake into adrenergic storage vesicles and serves as a high-affinity label for the vesicle transport system.
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Tetrabenazine Metabolite
(-)-β-HTBZ, (-)-β-Dihydrotetrabenazine
T13133924854-60-4
Tetrabenazine Metabolite ((-)-β-HTBZ), a vesicles monoamine transporter 2 (VMAT2) inhibitor, is an active metabolite of Tetrabenazine. Tetrabenazine Metabolite has a high affinity for VMAT2 with a Ki of 13.4 nM. Tetrabenazine Metabolite is often used to study chorea associated with Huntington's disease and other hyperactivity disorders.
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(+)-Tetrabenazine
(+)-TBZ, (3R,11bR)-Tetrabenazine, (3R,11bR)-TBZ
T131341026016-83-0
(+)-Tetrabenazine ((3R,11bR)-Tetrabenazine) is a reversible vesicular monoamine transporter 2 (VMAT-2) inhibitor, inhibits transport by VMAT2 with 10-fold greater potency than transport by VMAT1.
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10-14 weeks
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NBI-98782
(+)-α-Dihydrotetrabenazine, (+)-α-DHTBZ, (+)-DTBZ
T756385081-18-1
NBI-98782 ((+)-α-DHTBZ) is an inhibtior of vesicular monoamine transporter (VMAT2) (Ki: 0.97 nM)
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Xanthoangelol
T1335462949-76-2
Xanthoangelol, which can be extracted from Angelica keiskei, inhibits obesity-induced inflammatory responses.Xanthoangelol has antimicrobial activity, inhibits monoamine oxidase, and induces apoptosis in neuroblastoma and leukemia cells.
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Valbenazine tosylate
NBI-98854
T224521639208-54-0
Valbenazine tosylate, the tosylate salt of valbenazine, is a vesicular monoamine transporter 2 (VMAT2) inhibitor with a Ki value of 150 nM while displaying no significant binding to VAMT1(Ki<10 μM).
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1-2 weeks
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Nisoxetine hydrochloride
T2307057754-86-6
Nisoxetine hydrochloride is a noradrenaline transporter (NET) inhibitor
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6-8 weeks
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Tetrabenazine Racemate
Nitoman, Ro 1-9569 Racemate, Rubigen, TETRABENAZINE
T3534718635-93-9
Tetrabenazine Racemate (Rubigen) is a selective and reversible inhibitor of vesicular monoamine transporter-2 (VMAT-2). Tetrabenazine Racemate blocks neurotransmitter uptake into adrenergic storage vesicles and has been used as a high-affinity label for the vesicle transport system.
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(+)-Kavain
Kavain, L-KAWAIN, (R)-KAWAIN
T4590500-64-1
(+)-Kavain ((R)-KAWAIN) is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B.
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Valbenazine
NBI-98854
T71471025504-45-3
Valbenazine (NBI-98854), a highly selective vesicular monoamine transporter 2(VMAT2) inhibitor, is approved for the treatment of tardive dyskinesia.
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Reserpine hydrochloride
Serpivite hydrochloride, Serpasil hydrochloride, Serpalan hydrochloride
T2177216994-56-2
Reserpine hydrochloride (Serpivite hydrochloride) is the salt form of Reserpine, an alkaloid that inhibits the uptake of norepinephrine into storage vesicles, leading to depletion of catecholamines and serotonin in central and peripheral axon terminals, with antihypertensive and antipsychotic potential.
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7-10 days
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J-147
J147
T19931146963-51-0
J-147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging. It is a curcumin derivative and a potent neurogenic and neuroprotective drug candidate initially developed for the treatment of neurodegenerative conditions associated with aging that impacts many pathways implicated in the pathogenesis of diabetic neuropathy.
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Jatrorrhizine
Yatrorizine, neprotin
T39333621-38-3
Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits monoamine oxidase (IC50 4 micromolar for MAO-A and 62 for MAO-B).
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MAO-B-IN-9
T606712416910-88-6
MAO-B-IN-9 is a monoamine oxidase B MAO-B inhibitor (IC50: 0.18 μM) that crosses the blood-brain barrier with potency, selectivity and time-dependence. MAO-B-IN-9 has neuroprotective effects against Aβ1-42-induced neuronal cell death, which may be related to the anti-aggregation effect of Aβ1-42.
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6-8 weeks
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Trans (2,3)-Dihydrotetrabenazine
(2R,3R,11bR)-rel-Dihydrotetrabenazine, (2R,3R,11bR)-rel-DHTBZ
T12190171598-74-6
Trans (2,3)-Dihydrotetrabenazine is a Tetrabenazine metabolite, shows inhibition activity on vesicular monoamine transporter (VMAT2).
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3-6 months
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MAO-A/SERT-IN-1
T2002563001361-38-9
MAO-A SERT-IN-1 acts as an inhibitor for both MAO-A and the serotonin transporter (SERT). It decreases the SERT-mediated reuptake of 5-HT and demonstrates neuroprotective properties in cellular inhibition models. Additionally, this compound has shown to alleviate depressive behaviors in both zebrafish and mice.
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8-10 weeks
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Decynium 22
T22714977-96-8
Decynium 22 is a plasma membrane monoamine transporter (PMAT) inhibitor
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FFN 511 hydrochloride
FFN 511 hydrochloride(1004548-96-2 Free base)
T22781L2596358-28-8
FFN 511 hydrochloride is a fluorescent pseudo-neurotransmitters (FFNs) targeting neuronal vesicular monoamine transporter 2 (VMA T2).FFN 511 hydrochloride inhibits the binding of 5-hydroxytryptamine to VMA T2-containing membranes and can be used for labelling of dopaminergic nerve endings in acute slices of in vivo cortex-striatum. The excitation and emission maxima are 406 and 501 nm, respectively.
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