T5399 |
GeA-69
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PARP
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GeA-69 是一种选择性变构 PARP14 大结构域 2 (MD2) 抑制剂,Kd 值为 2.1 µM。 |
T10406 |
Tuvusertib
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ATR inhibitor 1,M1774 |
Others
,
Chk
,
Apoptosis
,
ATM/ATR
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Tuvusertib 是一种可口服的共济失调毛细血管扩张和 Rad3相关(ATR)激酶抑制剂(Ki< 1 µΜ),具有选择性和潜在的抗肿瘤活性。Tuvusertib 选择性抑制 ATR 活性,阻断丝氨酸/苏氨酸蛋白激酶检查点激酶1 (CHK... |
T50098 |
TIQ-A
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PARP
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TIQ-A 是一种 PARP1 抑制剂,通过碱基切除修复途径参与 DNA 单链断裂修复。 PARP1 由 DNA 损伤触发,其过度激活已被认为是许多病理状况的致病因素,包括缺血和再灌注损伤、哮喘相关炎症和动脉粥样硬化形成。 |
T7318 |
Elimusertib
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BAY-1895344 |
ATM/ATR
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Elimusertib 是一种可口服的选择性ATR 抑制剂,IC50值为 7 nM。它具有抗肿瘤活性,可研究实体瘤和淋巴瘤。 |
T21320 |
Methoxyamine HCl
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TRC 102,TRC102,甲氧基胺盐酸盐,Methoxyamine,TRC-102 |
Others
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Methoxyamine HCl 与脱嘌呤/脱嘧啶 (AP) DNA 损伤位点共价结合并抑制碱基切除修复 (BER),这可能导致 DNA 链断裂和细胞凋亡增加。 Methoxyamine 是一种具有潜在佐剂活性的口服生物可利用的小分子抑制剂... |
T4971 |
5'-DEOXYADENOSINE
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5-脱氧腺嘌呤核苷,5′-dAdo |
Endogenous Metabolite
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5'-Deoxyadenosine 是正常受试者尿液中发现的氧化核苷,氧化核苷代表了用于确定遗传物质损伤程度的优秀生物标志物。 |
T25838 |
MS0017509
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MS-0017509,MS 0017509 |
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MS0017509 is a DNA damage repair inhibitor. |
T25839 |
MS0019266
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MS 0019266,MS-0019266 |
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MS0019266 is a DNA damage repair inhibitor. |
T10018 |
1-Methyladenine
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Others
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1-Methyladenine is a DNA alkylation product that undergoes damage reversal through oxidative demethylation for repair pu... |
T14282 |
Amuvatinib hydrochloride
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HPK 56 hydrochloride,MP470 hydrochloride |
Others
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Amuvatinib hydrochloride (MP470 hydrochloride) is an orally bioavailable multi-targeted tyrosine kinase inhibitor with p... |
T70873 |
M3541
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M3541 is a potent, selective, orally active ATM inhibitor with potential chemo-/radio-sensitizing and antineoplastic act... |
T69931 |
MFH290
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MFH290 is a novel cysteine (Cys)-directed covalent inhibitor of CDK12/13. MFH290 forms a covalent bond with Cys-1039 of ... |
T40345 |
AV-153
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AV-153 is a 1,4-dihydropyridine derivative with antimutagenic properties. It intercalates into DNA at single strand brea... |
T36701 |
Phosphoramide mustard (cyclohexanamine)
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Phosphoramide mustard cyclohexanamine is the major metabolite for Cyclophosphamide , with anticancer activitiy. Phosphor... |
T26981 |
Ceralasertib formate
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Ceralasertib,AZD-6738,AZD6738,AZD 6738 |
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Ceralasertib is an orally available inhibitor of ataxia telangiectasia and rad3 related (ATR) kinase. Ceralasertib selec... |
T63923 |
ATR-IN-5
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ATR-IN-5 是 ATR 的有效抑制剂。其中 ATR 是 PIKK 家族的成员,是一类参与基因组稳定性和 DNA 损伤修复的蛋白激酶。ATR-IN-5 对 ATR 激酶介导的疾病如增殖性疾病和癌症表现出研究潜力,信息来源于专利 CN11... |
T75335 |
Ethylenediaminetetraacetic acid dipotassium dihydrate
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Ethylenediaminetetraacetic acid (EDTA) dipotassium dihydrate 是抗凝血剂,可螯合重金属,解除毒性。Ethylenediaminetetraacetic acid dipotassi... |
T75021 |
SZUH280
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SZUH280 是一种有效的、选择性的 PROTACHDAC8降解剂,在 A549 细胞中的 DC50为 0.58 μM。SZUH280 诱导癌细胞凋亡 (apoptosis)。SZUH280 在癌细胞中阻碍 DNA 损伤修复,促进细胞放射... |
T32189 |
Iproplatin
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Code name: JM9,JM 9,JM-9,CHIP |
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Iproplatin is a synthetic second-generation platinum-containing compound related to cisplatin. Iproplatin binds to and f... |
T37729 |
IMP-1700
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IMP-1700 is an inhibitor of bacterial DNA repair.1It potentiates the activity of the quinolone antibiotic ciprofloxacin ... |