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Search Results for " cyclind1 "

20

Compounds

Cat No. Product Name Synonyms Targets
T11284 FIDAS-3 Others , Wnt/beta-catenin , Methionine Adenosyltransferase (MAT)
FIDAS-3, a stilbene derivative and potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A), exhibits anticancer activities by effectively competing with S-adenosylmethionine (SAM) for ...
T11285 FIDAS-5 Others
FIDAS-5, a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM, competitively inhibits S-adenosylmethionine (SAM) binding to MAT2A. It exhibits anticancer activities.
T8445 PU02 PU-02,6-[(1-Naphthalenylmethyl)thio]-9H-purine Apoptosis , 5-HT Receptor
PU02 (6-[(1-Naphthalenylmethyl)thio]-9H-purine) is a potent and selective antagonist of 5-HT3 receptor.
T11345L Lerociclib dihydrochloride G1T38 dihydrochloride CDK
Lerociclib dihydrochloride (G1T38 dihydrochloride) is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 2 nM and 1 nM for CDK6/CyclinD3 and CDK4/CyclinD1, respectively.
T22590 AT7519 TFA AT7519 trifluoroacetate Others
AT7519 is a kinase inhibitor (IC50: 0.19, 0.044, 0.51, 0.067, 0.66 and 0.018 μM for CDK1/cyclinB, CDK2/CyclinA, CDK2/Cyclin E, CDk4/CyclinD1, CDK6/Cyclin D3, CDk5/p35).
T11345 Lerociclib G1T38 CDK
Lerociclib (G1T38) is a potent and selective inhibitor of CDK4/6, with IC50s of 2nM, 1 nM for CDK6/CyclinD3 and CDK4/CyclinD1, respectively.
T15335 FN-1501 FLT , CDK
FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively). FN-1501 also has anticancer activity.
T6924 Riviciclib hydrochloride P276-00 Apoptosis , CDK
Riviciclib hydrochloride (P276-00) is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. Phase 2/3.
T13202 Trilaciclib hydrochloride G1T28 hydrochloride CDK
Trilaciclib hydrochloride (G1T28 hydrochloride) is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6).
T10096L Voruciclib CDK
Voruciclib is an orally active and selective CDK inhibitor (Ki: 0.626 nM-9.1 nM). Voruciclib represses the expression of MCL-1 in multiple models of diffuse large B-cell lymphoma. Voruciclib effectively blocks CDK9, the ...
T39957 CDK4/6-IN-6 CDK
CDK4/6-IN-6 is a potent CDK4/CDK6 inhibitor with Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.
T10898 Samuraciclib hydrochloride ICEC0942 hydrochloride,CT7001 hydrochloride Apoptosis , CDK
Samuraciclib hydrochloride (ICEC0942 hydrochloride) is a potent, selective, ATP competitive and oral active CDK7 inhibitor with IC50 of 41 nM. The selectivity of Samuraciclib hydrochloride is 45-, 15-, 230- and 30-fold h...
T6239 Palbociclib monohydrochloride PD 0332991 hydrochloride,Palbociclib hydrochloride,Palbociclib (PD-0332991) HCl CDK
Palbociclib monohydrochloride (PD 0332991 hydrochloride) is a selective inhibitor of CDK4/6 (IC50s: 11/16 nM). It exhibits no inhibition against a panel of 36 additional protein kinases.
T6312 R547 Ro 4584820 Apoptosis , GSK-3 , PKA , CDK
R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3α/β, while inactive to other kinases. Phase 1.
T2059 Purvalanol A NG-60 Apoptosis , CDK , Autophagy
Purvalanol A (NG-60) is an effective and cell-permeable CDK inhibitor with IC50 of 70/4/35/850 nM for cdk2-cyclin A/B/E, and cdk4-cyclin D1, respectively.
T6240 Palbociclib Isethionate Palbociclib (PD0332991) Isethionate,PD 0332991 isethionate CDK
Palbociclib Isethionate (PD 0332991 isethionate) is a selective inhibitor of CDK4/6 (IC50s: 11/16 nM). It exhibits no inhibition against a panel of 36 additional protein kinases.
T1778 AT7519 Hydrochloride AT7519 HCl,AT 7519 hydrochloride salt Apoptosis , GSK-3 , CDK
AT7519 Hydrochloride (AT7519 HCl) is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9.
T30600 BSJ-03-204 BSJ03204
BSJ-03-204 is a selective Cdk4/6 degrader.
T23092 NSC 625987 Others
Cyclin-dependent kinase (cdk) 4 inhibitor
T12737 Riviciclib P276-00 (free base) Others
Riviciclib is a potent inhibitor of cyclin-dependent kinase (CDK)(CDK9-cyclinT1, CDK4-cyclin D1, and CDK1-cyclinB with IC50s of 20 nM, 63 nM, and 79 nM, respectively),with antitumor activity on cisplatin-resistant cells.
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