autophagy-in-2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T60749	Autophagy-IN-2
	Autophagy-IN-2 (Compound 7h) is an inhibitor of autophagic flux which induces cancer cell apoptosis and can be used for the research of triple-negative breast cancer [1].
T5485	OSU-T315	OSU-T315 (1,5-regioisomer),ILK-IN-2	Apoptosis , Integrin , Autophagy
	OSU-T315 (OSU-T315 (1,5-regioisomer)) (1,5-regioisomer) is a ILK inhibitor.		Apoptosis , Integrin , Autophagy
T15268	FAAH-IN-2	O-Desmorpholinopropyl Gefitinib	FAAH , Autophagy
	FAAH-IN-2 (O-Desmorpholinopropyl Gefitinib) is a potent inhibitor of FAAH(fatty acid amide hydrolase).		FAAH , Autophagy
T60967	Atg4B-IN-2		Phospholipase , Autophagy
	Atg4B-IN-2 is a potent and selective Atg4B inhibitor with anticancer activity that inhibits the activity of Atg4B and PLA2.Atg4B-IN-2 resists the anticancer activity of anti-desiccation-resistant prostate cancer drugs th...		Phospholipase , Autophagy
T77611	DAPK-IN-2	WAY-380496	DAPK
	DAPK-IN-2 (WAY-380496) is a DAPK inhibitor. DAPK-IN-2 has potential anticancer activity, regulates autophagy and can be used to study cerebral infarction and ischemic diseases.		DAPK
TN6705	Graveoline	2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one,Foliosine	Autophagy
	Graveoline (2-(Benzo[d][1,3]dioxol-5-yl)-1-methylquinolin-4(1H)-one) is an apoptosis and autophagy inducer in skin melanoma cancer cells		Autophagy
T71961	TUN-92046	DM-α-KG,T71961,Dimethyl 2-ketoglutarate,Dimethyl 2-oxoglutarate	Others
	TUN-92046 (Dimethyl 2-oxoglutarate) is a membrane-permeable alpha-ketoglutarate analogue that inhibits maladaptive autophagy in pressure overloading induced cardiomyopathy.		Others
T24167	Inflachromene	ICM	Others
	Inflachromene (ICM) is an inhibitor of HMGB1 and HMGB expression with anti-inflammatory activity.Inflachromene reduces seizure severity in a mouse model of epilepsy by inhibiting HMGB1 translocation, inhibits endothelial...		Others
T14091	AC-73		Autophagy
	AC-73 is an orally available Cluster of Differentiation 147 (CD147) inhibitor with high bioavailability that selectively disrupts the dimerization of CD147 (the binding site is in the N-terminal IgC2 domain of CD147 incl...		Autophagy
T4S1962	Beta-Asarone	Cis-Isoasarone,Cis-Asarone,Cis-Isoelemicin	NF-κB , JNK
	1. beta-Asarone (Cis-Isoelemicin) may be a potential preventive drug for Alzheimer's disease. 2. Beta-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in SAMP8 mice. 3. The co-administration of be...		NF-κB , JNK
T8689	Chloroquine	CQ	SARS-CoV , TLR , HIV Protease , Antibiotic , Parasite , Autophagy
	Chloroquine is a Toll-like receptor inhibitor that inhibits autophagy. Chloroquine has anti-malarial and anti-inflammatory activity and is widely used in the treatment of malaria and rheumatoid arthritis. Chloroquine als...
T60202	MMRi62	7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol	Ferroptosis
	MMRi62 (7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol), a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53). MMRi62 shows a P53-independent pro-apoptotic activity aga...		Ferroptosis
T3S1471	Cucurbitacin IIA	Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA	Apoptosis , Survivin
	1. Cucurbitacin IIA (Dihydrocucurbitacin Q1) can induce apoptosis and enhance autophagy , contributes to the anti-inflammatory activity of Cucurbitacin IIA against inflammation-related diseases. 2. Cucurbitacin IIA is a ...		Apoptosis , Survivin
T2310L	CHIR-99021 HCl	CT99021 HCl,Laduviglusib HCl	GSK-3
	CHIR-99021 HCl (Laduviglusib HCl) is a highly potent and selective inhibitor of GSK-3α/β, with IC50 values of 10 nM and 6.7 nM respectively. It demonstrates remarkable selectivity for GSK-3, with over 500-fold selectivit...		GSK-3
T61547	ATG7-IN-2
	ATG7-IN-2 (compound 1) is a highly potent inhibitor of the ATG7 protein, displaying an IC 50 value of 0.089 μM. This compound effectively suppresses the activity of autophagy marker LC3B, thereby regulating the autophagy...
T26973	Cefatrizine	Cephatriazine,BL-S-640,BLS640,S 640P,BL S 640
	Cefatrizine is an inhibitor of eukaryotic elongation factor-2 kinase, a unique calcium/calmodulin-dependent protein kinase, is well known to regulate apoptosis, autophagy and ER stress in many types of human cancers.
T61659	CC214-2
	CC214-2 is a potent dual inhibitor of mTORC1 and mTORC2, known for its ability to impede autophagy by modulating mammalian target of rapamycin (mTOR) signaling. With this capacity, CC214-2 shows promise in shortening the...
T74304	C16 PEG-Ceramide
	C16 PEG-Ceramide, a polyethylene glycolylated ceramide, serves as a lipid carrier for delivery and induces autophagy. It is utilized in cancer research [1] [2].
T60760	HDAC10-IN-2
	HDAC10-IN-2 (compound 10c) regulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells. HDAC10-IN-2 is a potent and highly selective inhibitor of HDAC10 (IC50 = 20 nM) [1].
T61344	VO-OHPic
	VO-OHPic is a reversible, noncompetitive, and selective inhibitor of PTEN with an IC50 of 46 nM. It effectively attenuates apoptosis, adverse cardiac remodeling, and the presence of pro-inflammatory M1 macrophages in mod...