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Ligand for Target Protein for PROTAC

Cat. No. Product name CAS No. Purity Chemical Structure
T18601 Desmethyl-QCA276 2126819-55-2 98%
Desmethyl-QCA276
Desmethyl-QCA276, the QCA276-based moiety, binds to cereblon ligand via a linker to form PROTAC to degrade BET. QCA276 is a BET inhibitor with an IC50 of 10 nM, ...
T18650 Ch55-O-C3-NH2 144298-98-6 98%
Ch55-O-C3-NH2
Ch55-O-C3-NH2, also known as RAR ligand 1, is a ligand derived from the Ch55 compound that specifically targets RAR. Through a linker, Ch55-O-C3-NH2 interacts wi...
T13843 PROTAC IRAK4 ligand-1 2357108-39-3 98%
PROTAC IRAK4 ligand-1
PROTAC IRAK4 ligand-1 is a synthetic ligand for interleukin-1 receptor-associated kinase 4.
T10320 Androgen receptor antagonist 1 1338812-36-4 98%
Androgen receptor antagonist 1
Androgen receptor antagonist 1 is an orally available full androgen receptor antagonist (IC50: 59 nM). It can be used in the synthesis of PROTAC AR degraders, wh...
T13888 SLF 195513-96-3 98%
SLF
SLF is a synthetic ligand for FK506-binding protein (FKBP)( with an affinity of 3.1 μM for FKBP51 and an IC50 of 0.22 μM for FKBP12). SLF can be used in the synt...
T10345 Apcin-A 1683617-62-0 98%
Apcin-A
Apcin-A is an anaphase-promoting complex (APC) inhibitor. It interacts strongly with Cdc20 and inhibits the ubiquitination of Cdc20 substrates. Apcin-A can be us...
T12558 PROTAC BET-binding moiety 2 916493-82-8 98%
PROTAC BET-binding moiety 2
PROTAC BET-binding moiety 2 is an BET bromodomain inhibitor.
T12905 SI-109 98%
SI-109
SI-109 is a potent inhibitor of STAT3 SH2 domain (Ki=9 nM),and with antitumor activity.
T17940 Estrone-N-O-C1-amido 138219-84-8 98%
Estrone-N-O-C1-amido
Estrone-N-O-C1-amido (ERα ligand 1) is an estrogen ligand derived from Estrone that specifically binds to estrogen receptor α (ERα). Through a linker, Estrone-N-...
T10734L CDK ligand for PROTAC hydrochloride 98%
CDK ligand for PROTAC hydrochloride
CDK ligand for PROTAC hydrochloride is a CDK inhibitor with antitumor activity. It has been used to design PROTAC CDK4/6 degraders.
T13841 PROTAC Her3-binding moiety 1 1603845-36-8 98%
PROTAC Her3-binding moiety 1
PROTAC Her3-binding moiety 1 is a Her3 Ligand for PROTAC.
T13086 I-BET762 carboxylic acid 1300019-38-8 98%
I-BET762 carboxylic acid
I-BET762 carboxylic acid is an inhibitor of BRD4(pIC50 of 5.1).
T12557 PROTAC BET-binding moiety 1 2093387-77-8 98%
PROTAC BET-binding moiety 1
PROTAC BET-binding moiety 1 is a key intermediate in the synthesis of high affinity BET inhibitors
T18053 Ipatasertib-NH2 1001382-14-4 98%
Ipatasertib-NH2
Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for target protein AKT for PROTAC, binds to lenalidomide, a ligand of ubiquitin E3 ligase cereblon (CRBN), ...
T13914 SLF-amido-C2-COOH 1092369-24-8 98%
SLF-amido-C2-COOH
SLF-amido-C2-COOH is a synthetic ligand for FKBP (SLF), and can be used in the synthesis of PROTACs.
T18611 AP1867-2-(carboxymethoxy) 2230613-03-1 98%
AP1867-2-(carboxymethoxy)
AP1867-2-(carboxymethoxy), a moiety based on the synthetic FKBP12F36V-directed ligand AP1867, connects to the CRBN ligand through a linker to generate dTAG molec...
T13915 PROTAC BRD9-binding moiety 1 2097512-23-5 98%
PROTAC BRD9-binding moiety 1
PROTAC BRD9-binding moiety 1 that binds to BRD9, and used for inhibiting BRD9 activity, based on PROTAC.
T18592 Imatinib carbaldehyde 1436868-85-7 98%
Imatinib carbaldehyde
Imatinib carbaldehyde (also known as CGP-57148B carbaldehyde) is a compound derived from Imatinib, an inhibitor of the ABL protein. Imatinib carbaldehyde binds t...
T10743 CDK9-IN-11 2748368-15-0 98%
CDK9-IN-11
CDK9-IN-11 is a potent CDK9 inhibitor that is the ligand for the PROTAC CDK9 Degrader-1 [1].
T10522 BET-IN-6 2570470-39-0 98%
BET-IN-6
BET-IN-6, a ligand with potent and high affinity for inhibiting BRD2/BRD4, plays a crucial role in the synthesis of PROTAC BRD2/BRD4 degrader-1 [1], targeting th...
Desmethyl-QCA276
T18601
Desmethyl-QCA276, the QCA276-based moiety, binds to cereblon ligand via a linker to form PROTAC to degrade BET. QCA276 is a BET inhibitor with an IC50 of 10 nM, ...
Ch55-O-C3-NH2
T18650
Ch55-O-C3-NH2, also known as RAR ligand 1, is a ligand derived from the Ch55 compound that specifically targets RAR. Through a linker, Ch55-O-C3-NH2 interacts wi...
PROTAC IRAK4 ligand-1
T13843
PROTAC IRAK4 ligand-1 is a synthetic ligand for interleukin-1 receptor-associated kinase 4.
Androgen receptor antagonist 1
T10320
Androgen receptor antagonist 1 is an orally available full androgen receptor antagonist (IC50: 59 nM). It can be used in the synthesis of PROTAC AR degraders, wh...
SLF
T13888
SLF is a synthetic ligand for FK506-binding protein (FKBP)( with an affinity of 3.1 μM for FKBP51 and an IC50 of 0.22 μM for FKBP12). SLF can be used in the synt...
Apcin-A
T10345
Apcin-A is an anaphase-promoting complex (APC) inhibitor. It interacts strongly with Cdc20 and inhibits the ubiquitination of Cdc20 substrates. Apcin-A can be us...
PROTAC BET-binding moiety 2
T12558
PROTAC BET-binding moiety 2 is an BET bromodomain inhibitor.
SI-109
T12905
SI-109 is a potent inhibitor of STAT3 SH2 domain (Ki=9 nM),and with antitumor activity.
Estrone-N-O-C1-amido
T17940
Estrone-N-O-C1-amido (ERα ligand 1) is an estrogen ligand derived from Estrone that specifically binds to estrogen receptor α (ERα). Through a linker, Estrone-N-...
CDK ligand for PROTAC hydrochloride
T10734L
CDK ligand for PROTAC hydrochloride is a CDK inhibitor with antitumor activity. It has been used to design PROTAC CDK4/6 degraders.
PROTAC Her3-binding moiety 1
T13841
PROTAC Her3-binding moiety 1 is a Her3 Ligand for PROTAC.
I-BET762 carboxylic acid
T13086
I-BET762 carboxylic acid is an inhibitor of BRD4(pIC50 of 5.1).
PROTAC BET-binding moiety 1
T12557
PROTAC BET-binding moiety 1 is a key intermediate in the synthesis of high affinity BET inhibitors
Ipatasertib-NH2
T18053
Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for target protein AKT for PROTAC, binds to lenalidomide, a ligand of ubiquitin E3 ligase cereblon (CRBN), ...
SLF-amido-C2-COOH
T13914
SLF-amido-C2-COOH is a synthetic ligand for FKBP (SLF), and can be used in the synthesis of PROTACs.
AP1867-2-(carboxymethoxy)
T18611
AP1867-2-(carboxymethoxy), a moiety based on the synthetic FKBP12F36V-directed ligand AP1867, connects to the CRBN ligand through a linker to generate dTAG molec...
PROTAC BRD9-binding moiety 1
T13915
PROTAC BRD9-binding moiety 1 that binds to BRD9, and used for inhibiting BRD9 activity, based on PROTAC.
Imatinib carbaldehyde
T18592
Imatinib carbaldehyde (also known as CGP-57148B carbaldehyde) is a compound derived from Imatinib, an inhibitor of the ABL protein. Imatinib carbaldehyde binds t...
CDK9-IN-11
T10743
CDK9-IN-11 is a potent CDK9 inhibitor that is the ligand for the PROTAC CDK9 Degrader-1 [1].
BET-IN-6
T10522
BET-IN-6, a ligand with potent and high affinity for inhibiting BRD2/BRD4, plays a crucial role in the synthesis of PROTAC BRD2/BRD4 degrader-1 [1], targeting th...
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