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YAP

YAP (Yes-associated protein) is a transcription co-activator in the Hippo tumor suppressor pathway and controls cell growth, tissue homeostasis and organ size. YAP is inhibited by the kinase Lats, which phosphorylates YAP to induce its cytoplasmic localization and proteasomal degradation. YAP induces gene expression by binding to the TEAD family transcription factors. The function of YAP in human cancer is complex and could be cell-type-dependent. For instance, YAP could function as a tumor suppressor in some cell types, such as hematological cancers, by inducing apoptosis in response to DNA damage.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T79427 LM-41 98%
LM-41
LM-41, a Flufenamic acid-derived TEAD inhibitor, significantly reduces the expression of CTGF, Cyr61, Axl, and NF2, and inhibits the migration of human MDA-MB-23...
T79428 AF-2112 98%
AF-2112
AF-2112, a TEAD inhibitor derived from Flufenamic acid, significantly diminishes the expression of CTGF, Cyr61, Axl, and NF2.
T79687 TEAD-IN-6 2821763-12-4 98%
TEAD-IN-6
TEAD-IN-6 (Example 11-1) is a TEAD modulator that inhibits the YAP1/TAZ-TEAD interaction, and has applications in cancer research [1].
T81056 SWTX-143 2766575-48-6 98%
SWTX-143
SWTX-143, a novel covalent inhibitor, specifically and irreversibly binds to the palmitoylation pocket of all four TEAD isoforms, inhibiting the transcriptional ...
T72888 YAP-TEAD-IN-2 2714432-83-2 98%
YAP-TEAD-IN-2
YAP-TEAD-IN-2 (compound 6) serves as a potent inhibitor of the YAP-TEAD protein-protein interaction (PPI), demonstrating an inhibitory concentration 50 (IC50) va...
T8421 TED-347 2378626-29-8 99.91%
TED-347
TED-347 is an irreversible and covalent inhibitor of TEAD4-Yap1 protein-protein interaction(EC50 of 5.9 μM), and inhibits glioblastoma cell viability.
T3050 ML-7 hydrochloride 110448-33-4 99.61%
ML-7 hydrochloride
ML-7 hydrochloride (ML-7 HCl) is a cell-permeable, reversible, effective, ATP-competitive, and specific inhibitor of myosin light chain kinase (Ki: 300 nM); also...
T77729 MY-1076 3008262-76-5 99.57%
MY-1076
MY-1076 is a potent YAP inhibitor with antigastric cancer activity.MY-1076 dose-dependently induced G2/M phase block, induced YAP degradation and apoptosis, and ...
TP2160L1 YAP-TEAD-IN-1 acetate TP2160L1 99.57%
YAP-TEAD-IN-1 acetate
YAP-TEAD-IN-1 acetate is an effective and competitive inhibitor of YAP–TEAD interaction with an IC50 of 25 nM.
T67872 VT104 2417718-25-1 99.5%
VT104
VT104 is a potent YAP/TAZ inhibitor with oral activity that can be used in cancer research. VT104 prevents palmitylation of endogenous TEAD1 and TEAD3 proteins.
T9566 PY-60 2765218-56-0 99.32%
PY-60
PY-60 potently activates YAP transcriptional activities targeting annexin A2 (Kd = 1.4 µM). PY-60 activates a proproliferative, YAP-dependent transcriptional pro...
T69760 TT-10 2230640-94-3 99.29%
TT-10
TT-10 (TAZ-K), an activator of YES-associated protein (YAP)-transcriptional enhancer factor domain (TEAD) activity, has potential application in heart disease re...
T77580 IK-930 2563892-44-2 98.86%
IK-930
IK-930 is an orally active TEAD inhibitor (EC50 < 0.1 µM) with potent potency.
T60218 YAP/TAZ inhibitor-2  2762617-31-0 98.84%
YAP/TAZ inhibitor-2 
YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC 50 value of 3 nM. YAP/TAZ inhibitor-2 shows anti-proliferative and antitumor ...
T64342 DC-TEADin02 2380228-45-3 98.82%
DC-TEADin02
DC-TEADin02 is an inhibitor of TEAD auto palmitoylation (IC50 = 197 nM). DC-TEADin02 can be in studies about development, regeneration, and tissue homeostasis.
T62077 VT103 2290608-13-6 98.73%
VT103
VT103 is an orally active and selective inhibitor of TEAD1 protein palmitoylation and is an analog of VT101. VT103 has potential antitumor activity by inhibiting...
T35545 VT107 2417718-63-7 98.43%
VT107
VT107 is a potent pan-TEAD auto-palmitoylation inhibitor. VT-107 can be used for the research of cancer[1].
T1477 AICAR 2627-69-2 98.21%
AICAR
AICAR (NSC105823) is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treat...
T3112 Verteporfin 129497-78-5 98.03%
Verteporfin
Verteporfin (BPD-MA) is a YAP inhibitor that inhibits YAP-TEAD interactions. Verteporfin is also a photosensitizer used in photodynamic therapy. Verteporfin also...
T77725 YAP-TEAD-IN-3 2714434-21-4 97.81%
YAP-TEAD-IN-3
YAP-TEAD-IN-3 is an inhibitor of YAP/TAZ-TEAD interactions with an IC50 of 9 nM for Avi-human TEAD (4217-434). YAP-TEAD-IN-3 inhibits YAP reporter gene expressio...
LM-41
T79427
LM-41, a Flufenamic acid-derived TEAD inhibitor, significantly reduces the expression of CTGF, Cyr61, Axl, and NF2, and inhibits the migration of human MDA-MB-23...
AF-2112
T79428
AF-2112, a TEAD inhibitor derived from Flufenamic acid, significantly diminishes the expression of CTGF, Cyr61, Axl, and NF2.
TEAD-IN-6
T79687
TEAD-IN-6 (Example 11-1) is a TEAD modulator that inhibits the YAP1/TAZ-TEAD interaction, and has applications in cancer research [1].
SWTX-143
T81056
SWTX-143, a novel covalent inhibitor, specifically and irreversibly binds to the palmitoylation pocket of all four TEAD isoforms, inhibiting the transcriptional ...
YAP-TEAD-IN-2
T72888
YAP-TEAD-IN-2 (compound 6) serves as a potent inhibitor of the YAP-TEAD protein-protein interaction (PPI), demonstrating an inhibitory concentration 50 (IC50) va...
TED-347
T8421
TED-347 is an irreversible and covalent inhibitor of TEAD4-Yap1 protein-protein interaction(EC50 of 5.9 μM), and inhibits glioblastoma cell viability.
ML-7 hydrochloride
T3050
ML-7 hydrochloride (ML-7 HCl) is a cell-permeable, reversible, effective, ATP-competitive, and specific inhibitor of myosin light chain kinase (Ki: 300 nM); also...
MY-1076
T77729
MY-1076 is a potent YAP inhibitor with antigastric cancer activity.MY-1076 dose-dependently induced G2/M phase block, induced YAP degradation and apoptosis, and ...
YAP-TEAD-IN-1 acetate
TP2160L1
YAP-TEAD-IN-1 acetate is an effective and competitive inhibitor of YAP–TEAD interaction with an IC50 of 25 nM.
VT104
T67872
VT104 is a potent YAP/TAZ inhibitor with oral activity that can be used in cancer research. VT104 prevents palmitylation of endogenous TEAD1 and TEAD3 proteins.
PY-60
T9566
PY-60 potently activates YAP transcriptional activities targeting annexin A2 (Kd = 1.4 µM). PY-60 activates a proproliferative, YAP-dependent transcriptional pro...
TT-10
T69760
TT-10 (TAZ-K), an activator of YES-associated protein (YAP)-transcriptional enhancer factor domain (TEAD) activity, has potential application in heart disease re...
IK-930
T77580
IK-930 is an orally active TEAD inhibitor (EC50 < 0.1 µM) with potent potency.
YAP/TAZ inhibitor-2 
T60218
YAP/TAZ inhibitor-2 is a potent and orally active TEAD-YAP/TAZ inhibitor with an EC 50 value of 3 nM. YAP/TAZ inhibitor-2 shows anti-proliferative and antitumor ...
DC-TEADin02
T64342
DC-TEADin02 is an inhibitor of TEAD auto palmitoylation (IC50 = 197 nM). DC-TEADin02 can be in studies about development, regeneration, and tissue homeostasis.
VT103
T62077
VT103 is an orally active and selective inhibitor of TEAD1 protein palmitoylation and is an analog of VT101. VT103 has potential antitumor activity by inhibiting...
VT107
T35545
VT107 is a potent pan-TEAD auto-palmitoylation inhibitor. VT-107 can be used for the research of cancer[1].
AICAR
T1477
AICAR (NSC105823) is an AMP-activated protein kinase activator which is used for the treatment of acute lymphoblastic leukemia and may have applications in treat...
Verteporfin
T3112
Verteporfin (BPD-MA) is a YAP inhibitor that inhibits YAP-TEAD interactions. Verteporfin is also a photosensitizer used in photodynamic therapy. Verteporfin also...
YAP-TEAD-IN-3
T77725
YAP-TEAD-IN-3 is an inhibitor of YAP/TAZ-TEAD interactions with an IC50 of 9 nM for Avi-human TEAD (4217-434). YAP-TEAD-IN-3 inhibits YAP reporter gene expressio...
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