TN2249 |
(+)-Syringaresinol
|
21453-69-0
|
98%
|
|
(+)-Syringaresinol shows antioxidant potential, it exhibits cytoprotective activity in cultured MCF-7 cells stressed by H2O2.
|
T13001 |
SRT3657
|
1383551-17-4
|
98%
|
|
SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.
|
T16667 |
PROTAC Sirt2 Degrader-1
|
2098487-75-1
|
98%
|
|
PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a b...
|
TN7093 |
N-Caffeoyltryptophan
|
109163-69-1
|
98%
|
|
N-Caffeoyltryptophan, a potential Sirt inhibitor, is screened using coffee extract. N-Caffeoyltryptophan inhibited Sirt2 (IC50; 8.7 μM) better than Sirt1(IC50; 3...
|
T77605 |
WAY-323061
|
550301-63-8
|
98%
|
|
WAY-323061 is a SIRT2 inhibitor.
|
T12918 |
SIRT-IN-1
|
1431411-60-7
|
98%
|
|
SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).
|
T12922 |
Sirtuin modulator 1
|
2070015-26-6
|
98%
|
|
Sirtuin modulator 1 is a modulator of SIRT1 with EC1.5 of < 1 μM.
|
T39233 |
SIRT7 inhibitor 97491
|
1807758-81-1
|
98%
|
|
SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.
|
T62515 |
SIRT2-IN-9
|
522650-91-5
|
98%
|
|
SIRT2-IN-9 is a selective SRIT2 inhibitor with an IC50 value of 1.3 μM.SIRT2-IN-9 inhibits the proliferation of MCF-7 breast cancer cells.SIRT2-IN-9 can be used ...
|
TN1296 |
5-Feruloylquinic acid
|
40242-06-6
|
98%
|
|
5-O-Feruloylquinic acid is a potent Sirt1 agonist, it is a potential lead compound that can be further tested in drug development process for diseases associated...
|
T50080 |
MC2184
|
74901-20-5
|
98%
|
|
MC2184 is the inhibitor of human recombinant SIRT1.
|
T16932 |
SRT 2183
|
1001908-89-9
|
98%
|
|
SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).
|
T4062 |
CAY10602
|
374922-43-7
|
98%
|
|
CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific s...
|
T8480 |
Tenovin-6 Hydrochloride
|
1011301-29-3
|
98%
|
|
Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent ...
|
T28543 |
RK-9123016
|
955900-27-3
|
98%
|
|
RK-9123016 is a SIRT2 inhibitor. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of ...
|
T4108 |
3-TYP
|
120241-79-4
|
98%
|
|
3-TYP is a selective SIRT3 inhibitor.
|
T9320 |
YK-3-237
|
1215281-19-8
|
98%
|
|
YK-3-237 reduces acetylation of mtp53 and exhibits anti-proliferative effects toward triple-negative breast cancer (TNBC) cells carrying mtp53.
|
T22094 |
JGB1741
|
1256375-38-8
|
98%
|
|
JGB1741 is a potent and selective inhibitor of SIRT1 with an IC50 of 15 μM. JGB1741 modulates Bax/Bcl2 ratio, cytochrome c release and PARP cleavage and increase...
|
T8346 |
SRT 1460
|
925432-73-1
|
98%
|
|
SRT1460 is a SIRT1 activator.
|
T1818 |
Tenovin-6
|
1011557-82-6
|
98%
|
|
Tenovin-6 is a p53 transcriptional activity agonist.
|