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Inhibitors Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling DNA Damage/DNA Repair Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation JAK/STAT signaling
MAPK Membrane transporter/Ion channel Metabolism Microbiology/Virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling Proteases/Proteasome Stem Cells Tyrosine Kinase/Adaptors Ubiquitination Others
Compound Libraries Focused Bioactive Libraries General Bioactive Libraries Approved / Repurposing Disease Focused Target / Pathway Focused Characteristic Bioactive Libraries Natural Product Libraries Natural Product Library for HTS Characteristic Natural Product Libraries Natural Product Derivatives Libraries Natural Product Library for CADD Drug-like Compound Libraries Fragment Libraries Custom Compound Library
Signaling Pathways Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling
DNA Damage/DNA Repair Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation JAK/STAT signaling MAPK Membrane transporter/Ion channel
Metabolism Microbiology/Virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling Proteases/Proteasome
Stem Cells Tyrosine Kinase/Adaptors Ubiquitination
Focused Bioactive Libraries General Bioactive Libraries Approved / Repurposing Disease Focused Target / Pathway Focused Characteristic Bioactive Libraries
Natural Product Libraries Natural Product Library for HTS Characteristic Natural Product Libraries Natural Product Derivatives Libraries Natural Product Library for CADD
Drug-like Compound Libraries Compound Libraries for HTS/HCS
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Sirtuin

Sirtuins are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. The name Sir2 comes from the yeast gene 'silent mating-type information regulation 2', the gene responsible for cellular regulation in yeast.
Cat. No. Product name CAS No. Purity Chemical Structure
TN2249 (+)-Syringaresinol 21453-69-0 98%
(+)-Syringaresinol shows antioxidant potential, it exhibits cytoprotective activity in cultured MCF-7 cells stressed by H2O2.
T13001 SRT3657 1383551-17-4 98%
SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.
T16667 PROTAC Sirt2 Degrader-1 2098487-75-1 98%
PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a b...
TN7093 N-Caffeoyltryptophan 109163-69-1 98%
N-Caffeoyltryptophan, a potential Sirt inhibitor, is screened using coffee extract. N-Caffeoyltryptophan inhibited Sirt2 (IC50; 8.7 μM) better than Sirt1(IC50; 3...
T77605 WAY-323061 550301-63-8 98%
WAY-323061 is a SIRT2 inhibitor.
T12918 SIRT-IN-1 1431411-60-7 98%
SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).
T12922 Sirtuin modulator 1 2070015-26-6 98%
Sirtuin modulator 1 is a modulator of SIRT1 with EC1.5 of < 1 μM.
T39233 SIRT7 inhibitor 97491 1807758-81-1 98%
SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.
T62515 SIRT2-IN-9 522650-91-5 98%
SIRT2-IN-9 is a selective SRIT2 inhibitor with an IC50 value of 1.3 μM.SIRT2-IN-9 inhibits the proliferation of MCF-7 breast cancer cells.SIRT2-IN-9 can be used ...
TN1296 5-Feruloylquinic acid 40242-06-6 98%
5-O-Feruloylquinic acid is a potent Sirt1 agonist, it is a potential lead compound that can be further tested in drug development process for diseases associated...
T50080 MC2184 74901-20-5 98%
MC2184 is the inhibitor of human recombinant SIRT1.
T16932 SRT 2183 1001908-89-9 98%
SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).
T4062 CAY10602 374922-43-7 98%
CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific s...
T8480 Tenovin-6 Hydrochloride 1011301-29-3 98%
Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent ...
T28543 RK-9123016 955900-27-3 98%
RK-9123016 is a SIRT2 inhibitor. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of ...
T4108 3-TYP 120241-79-4 98%
3-TYP is a selective SIRT3 inhibitor.
T9320 YK-3-237 1215281-19-8 98%
YK-3-237 reduces acetylation of mtp53 and exhibits anti-proliferative effects toward triple-negative breast cancer (TNBC) cells carrying mtp53.
T22094 JGB1741 1256375-38-8 98%
JGB1741 is a potent and selective inhibitor of SIRT1 with an IC50 of 15 μM. JGB1741 modulates Bax/Bcl2 ratio, cytochrome c release and PARP cleavage and increase...
T8346 SRT 1460 925432-73-1 98%
SRT1460 is a SIRT1 activator.
T1818 Tenovin-6 1011557-82-6 98%
Tenovin-6 is a p53 transcriptional activity agonist.
(+)-Syringaresinol
TN2249
(+)-Syringaresinol shows antioxidant potential, it exhibits cytoprotective activity in cultured MCF-7 cells stressed by H2O2.
SRT3657
T13001
SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.
PROTAC Sirt2 Degrader-1
T16667
PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a b...
N-Caffeoyltryptophan
TN7093
N-Caffeoyltryptophan, a potential Sirt inhibitor, is screened using coffee extract. N-Caffeoyltryptophan inhibited Sirt2 (IC50; 8.7 μM) better than Sirt1(IC50; 3...
WAY-323061
T77605
WAY-323061 is a SIRT2 inhibitor.
SIRT-IN-1
T12918
SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).
Sirtuin modulator 1
T12922
Sirtuin modulator 1 is a modulator of SIRT1 with EC1.5 of < 1 μM.
SIRT7 inhibitor 97491
T39233
SIRT7 inhibitor 97491 is an HDAC inhibitor with high specificity for SIRT7 (IC50 = 325 nM). SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.
SIRT2-IN-9
T62515
SIRT2-IN-9 is a selective SRIT2 inhibitor with an IC50 value of 1.3 μM.SIRT2-IN-9 inhibits the proliferation of MCF-7 breast cancer cells.SIRT2-IN-9 can be used ...
5-Feruloylquinic acid
TN1296
5-O-Feruloylquinic acid is a potent Sirt1 agonist, it is a potential lead compound that can be further tested in drug development process for diseases associated...
MC2184
T50080
MC2184 is the inhibitor of human recombinant SIRT1.
SRT 2183
T16932
SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).
CAY10602
T4062
CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific s...
Tenovin-6 Hydrochloride
T8480
Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent ...
RK-9123016
T28543
RK-9123016 is a SIRT2 inhibitor. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of ...
3-TYP
T4108
3-TYP is a selective SIRT3 inhibitor.
YK-3-237
T9320
YK-3-237 reduces acetylation of mtp53 and exhibits anti-proliferative effects toward triple-negative breast cancer (TNBC) cells carrying mtp53.
JGB1741
T22094
JGB1741 is a potent and selective inhibitor of SIRT1 with an IC50 of 15 μM. JGB1741 modulates Bax/Bcl2 ratio, cytochrome c release and PARP cleavage and increase...
SRT 1460
T8346
SRT1460 is a SIRT1 activator.
Tenovin-6
T1818
Tenovin-6 is a p53 transcriptional activity agonist.
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