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T0934 Nicotinamide Niacinamide is an important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue an...
T1558 Resveratrol Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.
T1818 Tenovin-6 Tenovin-6 is a p53 transcriptional activity agonist.
T1873 Tenovin-3 Tenovin-3 is a p53 activator.
T1887 Inauhzin Inauhzin(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human Y cells without...
T2412 SRT1720 hydrochloride SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM).
T2879 Fisetin Fisetin (Fustel), an agent extracted from Rhus succedanea L, can modulate sirtuins.
T2S0300 Hydrocoumarin Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 wi...
T3447 Thiomyristoyl Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.
T3953 Salermide Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.
T4019 Cambinol Cambinol is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-...
T4062 CAY10602 CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific ...
T4108 3-TYP 3-TYP is a selective SIRT3 inhibitor.
T4328 OSS_128167 OSS_128167 is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).
T5096 SRT 1720 SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.
T5124 SRT 1720 dihydrochloride[925434-55-5(free base)] SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).
T5490 AK-7 AK-1 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models.with an IC50 of 15.5 μM
T5618 AK-1 AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50:12.5 M).that prevents hippocampal neurodegeneration in Alzheimer's disease models and induces cell cycle arrest in ...
T5725 lithospermic acid B lithospermic acid B is a water-soluble antioxidant from Salvia extract. It plays significant role of antioxidant effect; antiplatelet aggregation, anticoagulant...
T6111 Selisistat EX 527 is an effective and specific SIRT1 inhibitor (IC50: 38 nM) and shows >200-fold selectivity against SIRT2/3.
T6220 Nicotinamide riboside chloride Nicotinamide riboside chloride, also known as NR and SRT647, is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine d...
T6371 AGK2 AGK2(IC50=3.5 μM) is an effective, and specific SIRT2 inhibitor.
T6671 Sirtinol Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).
T6678 Splitomicin Splitomicin (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell-based assay.
T6679 SRT2104 SRT2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.
T6984 SirReal2 SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.
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