Niacinamide is an important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue an...
SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively). |
SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 4, 7 μM, respectively). |
Sirt2-IN-1 is a inhibitor of sirtuin 2 (Sirt2)(IC50 of 163 nM). |
SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect. |
Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-i...
Selisistat R-enantiomer is much less active R-enantiomer of Selisistat (IC50 of > 100 μM for SIRT1). |
Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc. |
||PROTAC Sirt2 Degrader-1
PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a ...
SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM). |
Tenovin-6 is a p53 transcriptional activity agonist. |
Tenovin-3 is a p53 activator. |
Inauhzin(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human Y cells without...
SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM). |
Fisetin (Fustel), an agent extracted from Rhus succedanea L, can modulate sirtuins. |
Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 wi...
Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM. |
Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death. |
Cambinol is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-...
CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific ...
3-TYP is a selective SIRT3 inhibitor. |
OSS_128167 is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM). |
SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3. |
||SRT 1720 dihydrochloride[925434-55-5(free base)]
SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM). |
AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models.with an IC50 of 15.5 μM |
AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50:12.5 M).that prevents hippocampal neurodegeneration in Alzheimer's disease models and induces cell cycle arrest in ...
||lithospermic acid B
lithospermic acid B is a water-soluble antioxidant from Salvia extract. It plays significant role of antioxidant effect; antiplatelet aggregation, anticoagulant...
EX 527 is an effective and specific SIRT1 inhibitor (IC50: 38 nM) and shows >200-fold selectivity against SIRT2/3. |
||Nicotinamide riboside chloride
Nicotinamide riboside chloride, also known as NR and SRT647, is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine d...
AGK2（IC50=3.5 μM） is an effective, and specific SIRT2 inhibitor. |
Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM). |
Splitomicin (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell-based assay. |
SRT2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator. |
SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM. |
UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM) |
SRT1460 is a SIRT1 activator. |
Ophiopogonin D' can activate SIRT1, it also noncompetitively inhibits UGT1A6 and UGT1A10. |
5-O-feruloylquinic acid is a potent Sirt1 agonist, it is a potential lead compound that can be further tested in drug development process for diseases associate...
(+)-Syringaresinol shows antioxidant potential, it exhibits cytoprotective activity in cultured MCF-7 cells stressed by H2O2. |