Home Tools
Log in
Cart
Chromatin/Epigenetic Sirtuin

Sirtuin

Sirtuins are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase, demyristoylase and depalmitoylase activity. The name Sir2 comes from the yeast gene 'silent mating-type information regulation 2',the gene responsible for cellular regulation in yeast.
Cat No. product name
T2412 SRT1720 hydrochlorideHOT SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM).
T6111 SelisistatHOT EX 527 is an effective and specific SIRT1 inhibitor (IC50: 38 nM) and shows >200-fold selectivity against SIRT2/3.
T1558 ResveratrolHOT Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.
T4062 CAY10602 CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific s...
T4019 Cambinol Cambinol is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-...
T4108 3-TYP 3-TYP is a selective SIRT3 inhibitor.
T0934 Nicotinamide Niacinamide is an important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and...
T6984 SirReal2 SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.
T6678 Splitomicin Splitomicin (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell-based assay.
T2879 Fisetin Fisetin is a natural flavonol extracted from Rhus succedanea L that is structurally and functionally related to kaempferol, can modulate sirtuins,with antioxidan...
T6671 Sirtinol Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).
T2S0300 Hydrocoumarin Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 wit...
T1887 Inauhzin Inauhzin(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human Y cells without ...
T6371 AGK2 AGK2(IC50=3.5 μM) is an effective, and specific SIRT2 inhibitor.
T2750 Ginkgolide C Ginkgolide C, a natural product, can enhance the cardiac function of rats in the body.
T3447 Thiomyristoyl Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.
T3953 Salermide Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.
T6679 SRT2104 SRT2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.
T1818 Tenovin-6 Tenovin-6 is a p53 transcriptional activity agonist.
T1873 Tenovin3 Tenovin-3 is a p53 activator.
T4328 OSS_128167 OSS_128167 is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).
T9106 E1231 E1231 is an activator of SIRT1 . E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression.
T21679 4'-bromo-Resveratrol 4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)
T13795 Nicotinamide riboside Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-in...
T8480 Tenovin-6 Hydrochloride Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a pote...
T16932 SRT 2183 SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).
T13001 SRT3657 SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.
T12920 Sirt2-IN-1 Sirt2-IN-1 is a inhibitor of sirtuin 2 (Sirt2)(IC50 of 163 nM).
T12919 SIRT-IN-2 SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).
T12918 SIRT-IN-1 SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).
T15263 Selisistat R-enantiomer Selisistat R-enantiomer is much less active R-enantiomer of Selisistat (IC50 of > 100 μM for SIRT1).
T16667 PROTAC Sirt2 Degrader-1 PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a b...
T8346 SRT1460 SRT1460 is a SIRT1 activator.
T5124 SRT 1720 dihydrochloride[925434-55-5(free base)] SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).
TN2249 (+)-Syringaresinol (+)-Syringaresinol shows antioxidant potential, it exhibits cytoprotective activity in cultured MCF-7 cells stressed by H2O2.
TN1296 5-O-Feruloylquinic acid 5-O-feruloylquinic acid is a potent Sirt1 agonist, it is a potential lead compound that can be further tested in drug development process for diseases associated...
TN1071 Ophiopogonin D' Ophiopogonin D' can activate SIRT1, it also noncompetitively inhibits UGT1A6 and UGT1A10.
T7679 UBCS039 UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)
T5618 AK-1 AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50:12.5 µM).that prevents hippocampal neurodegeneration in Alzheimer's disease models and induces cell cycle arrest in ...
T6220 Nicotinamide riboside chloride Nicotinamide riboside chloride, also known as NR and SRT647, is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine di...
T5725 Lithospermic acid B lithospermic acid B is a water-soluble antioxidant from Salvia extract. It plays significant role of antioxidant effect; antiplatelet aggregation, anticoagulant,...
T5490 AK-7 AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models with an IC50 of 15.5 μM.
T5096 SRT 1720 SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.
SRT1720 hydrochloride HOT
T2412CAS 1001645-58-4
SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM).
Selisistat HOT
T6111CAS 49843-98-3
EX 527 is an effective and specific SIRT1 inhibitor (IC50: 38 nM) and shows >200-fold selectivity against SIRT2/3.
Resveratrol HOT
T1558CAS 501-36-0
Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.
CAY10602
T4062CAS 374922-43-7
CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific s...
Cambinol
T4019CAS 14513-15-6
Cambinol is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-...
3-TYP
T4108CAS 120241-79-4
3-TYP is a selective SIRT3 inhibitor.
Nicotinamide
T0934CAS 98-92-0
Niacinamide is an important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and...
SirReal2
T6984CAS 709002-46-0
SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.
Splitomicin
T6678CAS 5690-03-9
Splitomicin (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell-based assay.
Fisetin
T2879CAS 528-48-3
Fisetin is a natural flavonol extracted from Rhus succedanea L that is structurally and functionally related to kaempferol, can modulate sirtuins,with antioxidan...
Sirtinol
T6671CAS 410536-97-9
Sirtinol is a selective SIRT1/2 inhibitor (IC50: 131/38 μM).
Hydrocoumarin
T2S0300CAS 119-84-6
Dihydrocoumarin is a compound found in Melilotus officinalis. Dihydrocoumarin is a yeast Sir2p inhibitor. Dihydrocoumarin also inhibits human SIRT1 and SIRT2 wit...
Inauhzin
T1887CAS 309271-94-1
Inauhzin(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human Y cells without ...
AGK2
T6371CAS 304896-28-4
AGK2(IC50=3.5 μM) is an effective, and specific SIRT2 inhibitor.
Ginkgolide C
T2750CAS 15291-76-6
Ginkgolide C, a natural product, can enhance the cardiac function of rats in the body.
Thiomyristoyl
T3447CAS 1429749-41-6
Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.
Salermide
T3953CAS 1105698-15-4
Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.
SRT2104
T6679CAS 1093403-33-8
SRT2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.
Tenovin-6
T1818CAS 1011557-82-6
Tenovin-6 is a p53 transcriptional activity agonist.
Tenovin3
T1873CAS 1011301-27-1
Tenovin-3 is a p53 activator.
OSS_128167
T4328CAS 887686-02-4
OSS_128167 is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).
E1231
T9106CAS 1031195-19-3
E1231 is an activator of SIRT1 . E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression.
4'-bromo-Resveratrol
T21679CAS 1224713-90-9
4'-bromo-Resveratrolis a potent inhibitor of the deacetylases sirtuin 1 (SIRT1) and 3 (SIRT3)
Nicotinamide riboside
T13795CAS 1341-23-7
Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-in...
Tenovin-6 Hydrochloride
T8480CAS 1011301-29-3
Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a pote...
SRT 2183
T16932CAS 1001908-89-9
SRT 2183 is a selective activator of Sirtuin-1 (SIRT1, EC1.5 : 0.36 μM).
SRT3657
T13001CAS 1383551-17-4
SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.
Sirt2-IN-1
T12920CAS 1862238-00-3
Sirt2-IN-1 is a inhibitor of sirtuin 2 (Sirt2)(IC50 of 163 nM).
SIRT-IN-2
T12919CAS 1431411-66-3
SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).
SIRT-IN-1
T12918CAS 1431411-60-7
SIRT-IN-1 is a potent SIRT1/2/3 inhibitor(IC50s of 15, 10, 33 μM, respectively).
Selisistat R-enantiomer
T15263CAS 848193-69-1
Selisistat R-enantiomer is much less active R-enantiomer of Selisistat (IC50 of > 100 μM for SIRT1).
PROTAC Sirt2 Degrader-1
T16667CAS 2098487-75-1
PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a b...
SRT1460
T8346CAS 925432-73-1
SRT1460 is a SIRT1 activator.
SRT 1720 dihydrochloride[925434-55-5(free base)]
T5124CAS T5124
SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).
(+)-Syringaresinol
TN2249CAS 21453-69-0
(+)-Syringaresinol shows antioxidant potential, it exhibits cytoprotective activity in cultured MCF-7 cells stressed by H2O2.
5-O-Feruloylquinic acid
TN1296CAS 40242-06-6
5-O-feruloylquinic acid is a potent Sirt1 agonist, it is a potential lead compound that can be further tested in drug development process for diseases associated...
Ophiopogonin D'
TN1071CAS 65604-80-0
Ophiopogonin D' can activate SIRT1, it also noncompetitively inhibits UGT1A6 and UGT1A10.
UBCS039
T7679CAS 358721-70-7
UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)
AK-1
T5618CAS 330461-64-8
AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50:12.5 µM).that prevents hippocampal neurodegeneration in Alzheimer's disease models and induces cell cycle arrest in ...
Nicotinamide riboside chloride
T6220CAS 23111-00-4
Nicotinamide riboside chloride, also known as NR and SRT647, is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine di...
lithospermic acid B
T5725CAS 121521-90-2
lithospermic acid B is a water-soluble antioxidant from Salvia extract. It plays significant role of antioxidant effect; antiplatelet aggregation, anticoagulant,...
AK-7
T5490CAS 420831-40-9
AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models with an IC50 of 15.5 μM.
SRT 1720
T5096CAS 925434-55-5
SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.