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Platelet aggregation

Platelets stop bleeding from damaged blood vessels and initiate repair processes In platelets, adhesion refers to the attachment of platelets to subendothelium or to other cells, while platelet-platelet “adhesion” is called aggregation to differentiate these processes clearly.

  • Protopine
    T3429130-86-9
    Protopine (Fumarine) is a benzylisoquinoline alkaloid. It has been found to inhibit histamine H1 receptors and platelet aggregation, and acts as an analgesic.
    • $50
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  • 48740 RP
    T1015993363-11-2In house
    48740 RP (RP 55779) is an antagonist of platelet-activating factor.
    • $375
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    TargetMol | Inhibitor Sale
  • ENFENAMIC ACID
    T857523049-93-6
    Enfenamic acid is a platelet aggregation inhibitor and with antirheumatic.
    • $133
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  • Cirsiumaldehyde
    TN69757389-38-0
    Cirsiumaldehyde is a compound isolated from the mature fruits of Lobelia chinensis, Cornus officinalis, and the fruits of Hippophae rhamnoides.Cirsiumaldehyde in the presence of collagen inhibited U46619-induced (1~5 uM) The inhibitory concentration of Cirsiumaldehyde on U46619-induced (1~5 uM) rat platelet aggregation in the presence of collagen was 0.8~1.0 ug/mL.
    • $50
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  • Rocepafant
    T28607132579-32-9In house
    Rocepafant (LAU8080) is a platelet-activating factor (PAF) antagonist that attenuates hypoxic-ischemic brain damage in neonatal rats.Rocepafant inhibits tumor necrosis factor-Afa-mediated cytotoxicity in mouse L929 tumor cells.
    • $76
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  • Dersalazine
    T70084188913-58-8In house
    Dersalazine (Dersalazine Free Base), an inhibitor of platelet-activating factor, exerts intestinal anti-inflammatory activity in different rodent types of colitis by down-regulating IL-17 expression, with potential efficacy in patients with ulcerative colitis.
    • $210
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  • SDZ-62-434
    T28740115621-95-9In house
    SDZ-62-434 is a platelet-activating factor inhibitor with antitumor activity that inhibits bombesin- and platelet-derived growth factor-induced DNA synthesis in quiescent Swiss 3T3 cells for the study of leukemia, human xenograft colorectal cancer, and lung cancer.
    • $293
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  • DF-1111301
    T27159160665-99-6In house
    DF-1111301 is a novel anti-allergic compound with anti-histamine H1 and anti-PAF activity.
    • $293 TargetMol
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  • ethyl 1-[(4-cyanobenzyl)oxy]-2-(3-cyanophenyl)-4-methyl-1H-imidazole-5-carboxylate
    T98872738381-94-5
    ethyl 1-[(4-cyanobenzyl)oxy]-2-(3-cyanophenyl)-4-methyl-1H-imidazole-5-carboxylate is a platelet aggregation inhibitor.
    • $195
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  • 1-Cinnamoylpyrrolidine
    TN117052438-21-8
    1-Cinnamoylpyrrolidine, a natural product prepared from Piper caninum, can be used as a DNA strand breaking agent, inducing the relaxation of the plasmid pBR322 DNA superhelix in the presence of Cu2+. 1-Cinnamoylpyrrolidine inhibits PAF-induced platelet aggregation with an IC50 value of 37.3 μM. value was 37.3 μM.
    • $115
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  • Benzcyclane
    T105022179-37-5In house
    Benzcyclane (Benzcyclan) is an inhibitor of platelet aggregation and also a vasodilator that can be used in a variety of peripheral circulation disorders.
    • $98
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  • Veratrosine
    TN1057475-00-3
    Veratrosine (Veratramine-beta-D-glucoside) is an alkaloid isolated from the herbs of Veratrum nigrum. Veratrosine exhibits feeble inhibition activity against platelet aggregation.
    • $139
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  • Carbasalate calcium
    T36085749-67-7
    Carbasalate calcium (Rheomin) is an analgesic, antipyretic, and anti-inflammatory drug, as well as a platelet aggregation inhibitor.
    • $39
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  • Pseudojervine
    TN234336069-05-3
    Pseudojervine (O-beta-D-Glucopyranosyljervine) is derived from Veratrum nigrum L. Pseudojervine exhibits feeble inhibition activity against platelet aggregation.
    • $58
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  • Xanthopurpurin
    TN2315518-83-2
    Xanthopurpurin shows antiviral activity. Xanthopurpurin can effectively inhibit rotavirus multiplication by promoting virus-induced apoptosis in MA-104 cells. Xanthopurpurin shows mainly strong inhibition of collagen-induced platelet aggregation.
    • $105
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  • Cycloolivil
    T38393064-05-9
    Cycloolivil (Isoolivil) is a natural polyphenolic compound with a significant radical scavenging activity present in olive trees. Cycloolivil has antioxidant activity, it may prevent thrombotic complications associated to platelet hyperaggregability and be the base
    • $93
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  • Dextran
    T110129004-54-0
    Dextran has an inhibitory effect on platelet aggregation and coagulation factors, and is used as an agent for increasing plasma volume.
    • $45
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  • Foropafant
    T15338136468-36-5
    Foropafant (SR27417) is a highly potent and selective platelet-activating factor (PAF) receptor antagonist (Ki: 57 pM). Foropafant potently inhibits the PAF-induced aggregation of rabbit and human platelets.
    • $84
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  • Timosaponin B III
    TN1383142759-74-8
    Timosaponin B III (Anemarsaponin BIII) is a bioactive steroidal saponin isolated from Anemarrhena asphodeloides Bge. Timosaponin B III possesses anti-inflammatory, anti-platelet aggregative and anti-depressive effects.
    • $84
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  • 3',4'-Dihydroxyacetophenone
    T37341197-09-7
    3',4'-Dihydroxyacetophenone (Qingxintong) is an active constituent of Chinese medicine. It is platelet aggregation Inhibitor and also has anti-arrhythmia activity.
    • $29
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  • 6-Deoxyjacareubin
    TN316116265-56-8
    6-Deoxyjacareubin exhibits potent antioxidant and antifungal activities. 6-Deoxyjacareubin inhibits platelet activating factor (PAF) receptor with an IC50 of 29.0 microM and can be used in studies about natural PAF receptor antagonists.
    • $829
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  • Quinine
    T0690130-95-0
    Quinine is a natural cinchona alkaloid that has been used for centuries in the prevention and therapy of malaria. Quinine is also used for idiopathic muscle cramps. Quinine therapy has been associated with rare instances of hypersensitivity reactions which can be accompanied by hepatitis and mild jaundice.
    • $39
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  • 4(3H)-Quinazolinone
    TMO2713491-36-1
    4(3H)-Quinazolinone (4-Hydroxyquinazoline) is a chemically synthesized masonry block, a biologically active nitrogen heterocyclic compound. It possesses various biological properties such as antibacterial, antifungal, anticonvulsant, anti-inflammatory, anti-HIV, anticancer and pain relieving activities.
    • $48
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  • NQ301
    T3757130089-98-4
    NQ301, an antithrombotic agent, inhibits collagen-challenged rabbit platelet aggregation (IC50: 10 mg/mL).
    • $53
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  • Homoeriodictyol 7-O-β-D-glucoside
    TN422214982-11-7
    Homoeriodictyol 7-O-β-D-glucoside (Homoeriodictyol 7-O-glucoside) is a natural product from Viscum coloratum(Kom.)Nakai. Homoeriodictyol 7-O-β-D-glucoside is an antagonist of platelet-activating factor (PAF).
    • $525
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  • SCH-37370
    T19686117796-52-8
    SCH-37370 is an effective and orally active dual antagonist of platelet-activating factor and histamine. Sch 37370 blocks the binding of [3H]pyrilamine to histamine-H1 receptors in rat brain membranes. Sch 37370 selectively inhibits PAF-induced aggregation of human platelets (IC50 : 0.6 mM) and also competes with PAF binding to specific sites in membrane preparations from human lungs (IC50 : 1.2 mM).
    • $95
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  • Suloctidil
    T071254767-75-8
    Suloctidil is a peripheral vasodilator that was formerly used in the management of peripheral and cerebral vascular disorders. It is hepatotoxic and fatalities have occurred.
    • $35
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    TargetMol | Citations Cited