T24741 |
RS1-PDK1 inhibitor
|
1643958-85-3
|
98%
|
|
RS1-PDK1 inhibitor is a selective inhibitor of the protein kinase PDK1 that can be used to treat and prevent disease or disorders.
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T16450 |
PDK1-IN-RS2
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1643958-89-7
|
98%
|
|
PDK1-IN-RS2 inhibits the activation of the downstream kinases S6K1 by PDK1. PDK1-IN-RS2 is a mimic of the peptide docking motif (PIFtide) and is a substrate-sele...
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T12566 |
PS10
|
1564265-82-2
|
98%
|
|
PS10 is a ATP-competitive inhibitor of pan-PDK(PDK2, PDK4, PDK1, and PDK3 with IC50 of 0.8 μM, 0.76 μM, 2.1 μM and 21.3 μM , respectively).
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T2420 |
PHT-427
|
1191951-57-1
|
98%
|
|
PHT-427 is a dual Akt (Ki: 2.7 μM) and PDPK1 (Ki: 5.2 μM) inhibitor (high-affinity binding for the PH domains of Akt and PDPK1).
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T22350 |
JX06
|
729-46-4
|
98%
|
|
JX06, a potent, selective and covalent PDK inhibitor, inhibits PDK1, PDK2 and PDK3 with IC50 of 49 nM, 101 nM and 313 nM respectively.
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T16670 |
PS210
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1221962-86-2
|
98%
|
|
PS210 is inactive against other protein kinases, including PDK1 downstream signaling components such as S6K, PKB/Akt, or GSK3. PS210 is a potent and selective PD...
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T12398 |
MP7
|
1001409-50-2
|
98%
|
|
MP7 is a inhibitor of phosphoinositide-dependent kinase-1 (PDK1).
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T3895 |
Polyphyllin I
|
50773-41-6
|
98%
|
|
Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, c...
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T1837 |
BX-912
|
702674-56-4
|
98%
|
|
BX-912 is a specific inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1, IC50: 12 nM). The selectivity of BX-912 is more 10 fold than C-Kit, EGFR, PKA, PKC...
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T17224 |
VER-246608
|
1684386-71-7
|
98%
|
|
VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK...
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T6084 |
Rabusertib
|
911222-45-2
|
98%
|
|
Rabusertib is an inhibitor of the cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiating activity. Rabusertib has been used in trials studying th...
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T24677 |
PS47
|
1180676-33-8
|
98%
|
|
PS-47 is an inactive E-isomer of PS48. PS48 is an activator of PDK1.
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T2466 |
Osu03012
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742112-33-0
|
98%
|
|
AR-12 is an orally bioavailable, small-molecule, celecoxib-derived inhibitor of phosphoinositide-dependent kinase-1 (PDK1) with potential antineoplastic activity...
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T11765 |
KPLH1130
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906669-07-6
|
98%
|
|
KPLH1130, a specific pyruvate dehydrogenase kinase (PDK) inhibitor, enhances glucose tolerance in mice fed a high-fat diet (HFD). It effectively hinders macropha...
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T3604 |
Sodium dichloroacetate
|
2156-56-1
|
98%
|
|
Dichloroacetate, a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to ...
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T3163 |
PS 48
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1180676-32-7
|
98%
|
|
PS 48 has been shown to be a PKB Kinase (PDK1) activator (Kd: 10.3 μM). This compound selectively binds to the PIF-binding pocket of PKB Kinase (PDK1).
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TMA2474 |
δ-Tocotrienol
|
25612-59-3
|
98%
|
|
Delta-tocotrienol is a potential angiogenic inhibitor, it (2.5-5 microM) can significantly suppress human colorectal adenocarcinoma cells (DLD-1-CM) -induced tub...
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T77685 |
6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile
|
1207836-10-9
|
98%
|
|
6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile is a PDK1 inhibitor with anticancer and antiproliferative activity that can be used to study angiosarcoma...
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T2348 |
GSK2334470
|
1227911-45-6
|
98%
|
|
GSK2334470 is a novel PDK1 inhibitor (IC50: ~10 nM, in a cell-free assay), with no inhibitory at other close related AGC-kinases.
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T12412L |
PDK4-IN-1 hydrochloride
|
2310262-11-2
|
98%
|
|
PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4)(IC50 value of 84 nM)
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