LPA Receptor

Lysophosphatidic acid (LPA) receptors are a group of G-protein-coupled receptors that are currently divided into six subtypes: LPA1, LPA2, LPA3, LPA4, LPA5 and LPA6. They belong to a family of lysophospholipid receptors that include S1P receptors.

Cat. No.	Product name	CAS No.	Purity
T14335	ASP6432	1282549-08-9	98%
ASP6432 is an antagonist of type 1 lysophosphatidic acid receptor (LPA1). For human LPA1 and rat LPA1, the IC50s are 11 nM and 30 nM , respectively.
T11875	LPA2 antagonist 2	36840-10-5	98%
LPA2 antagonist 2 is ＞480-fold more selective than LPA3 (IC50 of 13.85 μM).LPA2 antagonist 2 is a selective LPA2 antagonist with an IC50 of 28.3 nM and a Ki of 2...
T9699	TAK-615	1664335-55-0	98%
TAK-615 is commonly used to study pulmonary fibrosis and is a negative allosteric modulator of LPA1 receptors.
T7393	ONO-7300243	638132-34-0	98%
ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 : 0.16 µM).
T21654	1-Oleoyl lysophosphatidic acid sodium	325465-93-8	98%
1-Oleoyl lysophosphatidic acid sodium salt is an Endogenous agonist of LPA1 and LPA2
T22835	H2L5186303	139262-76-3	98%
H2L5186303 is an LPA2 antagonist and can be used in studies about asthma treatment.
T22070	DBIBB	1569309-92-7	98%
DBIBB is a non-lipid agonist of specific lysophosphatidic acid (LPA2) type 2 G-protein-coupled receptor. It is a potentially active molecule for the treatment of...
T6347	Ki16198	355025-13-7	98%
Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μ...
T15796	LX-1031	945976-76-1	98%
LX-1031 is an effective inhibitor of tryptophan 5-hydroxylase. LX-1031 decreases serotonin (5-HT) synthesis peripherally.
T7689	Tetradecyl Phosphonate	4671-75-4	98%
Tetradecyl phosphonate is a pan-antagonist of lysophosphatidic acid 1 (LPA1), LPA2, and LPA3 receptors.
T22812	GRI977143	325850-81-5	98%
GRI977143 is a selective and non-lipid agonist of LPA2 (EC50 = 3.3 μM). GRI977143 inhibits the activation of caspases 3, 7, 8, and 9 and and reduces DNA fragment...
T6108	Ki16425	355025-24-0	98%
Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively.
T4016	BMS-986020	1257213-50-5	98%
BMS-986020 is a selective antagonist of LPA1.
T23438	TC LPA5 4	1393814-38-4	98%
TC LPA5 4 is a LPA5 receptor antagonist.
T12684	Radioprotectin-1	1622006-09-0	98%
Radioprotectin-1 is a selective agonist of LPA2 with EC50 of 25 nM for murine LPA2 GPCR and exerts radioprotective and radiomitigative action.
T22834	H2L 5765834	420841-84-5	98%
H2L 5765834 is a lysophosphatidic acid receptors antagonist
T4278	AM966	1228690-19-4	98%
AM966, a excellent affinity, specific, oral LPA1(IC50=17 nM) antagonist, suppresses LPA-stimulated intracellular calcium release.
T2000	AM095	1345614-59-6	98%
AM095 is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively.
T4521	Edg-2 receptor inhibitor 1	1195941-38-8	98%
Edg-2 receptor inhibitor 1 is an Edg-2 receptor inhibitor extracted (IC50: <0.1 μM).
T10293	AM095 free acid	1228690-36-5	98%
AM095 (free acid) is a potent LPA1 receptor antagonist (IC50s: 0.98 and 0.73 μM for recombinant human or mouse LPA1).

Cat. No.

Product name

CAS No.

Purity

Chemical Structure

T14335

ASP6432

1282549-08-9

98%

ASP6432 is an antagonist of type 1 lysophosphatidic acid receptor (LPA1). For human LPA1 and rat LPA1, the IC50s are 11 nM and 30 nM , respectively.

T11875

LPA2 antagonist 2

36840-10-5

98%

LPA2 antagonist 2 is ＞480-fold more selective than LPA3 (IC50 of 13.85 μM).LPA2 antagonist 2 is a selective LPA2 antagonist with an IC50 of 28.3 nM and a Ki of 2...

T9699

TAK-615

1664335-55-0

98%

TAK-615 is commonly used to study pulmonary fibrosis and is a negative allosteric modulator of LPA1 receptors.

T7393

ONO-7300243

638132-34-0

98%

ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 : 0.16 µM).

T21654

1-Oleoyl lysophosphatidic acid sodium

325465-93-8

98%

1-Oleoyl lysophosphatidic acid sodium salt is an Endogenous agonist of LPA1 and LPA2

T22835

H2L5186303

139262-76-3

98%

H2L5186303 is an LPA2 antagonist and can be used in studies about asthma treatment.

T22070

DBIBB

1569309-92-7

98%

DBIBB is a non-lipid agonist of specific lysophosphatidic acid (LPA2) type 2 G-protein-coupled receptor. It is a potentially active molecule for the treatment of...

T6347

Ki16198

355025-13-7

98%

Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μ...

T15796

LX-1031

945976-76-1

98%

LX-1031 is an effective inhibitor of tryptophan 5-hydroxylase. LX-1031 decreases serotonin (5-HT) synthesis peripherally.

T7689

Tetradecyl Phosphonate

4671-75-4

98%

Tetradecyl phosphonate is a pan-antagonist of lysophosphatidic acid 1 (LPA1), LPA2, and LPA3 receptors.

T22812

GRI977143

325850-81-5

98%

GRI977143 is a selective and non-lipid agonist of LPA2 (EC50 = 3.3 μM). GRI977143 inhibits the activation of caspases 3, 7, 8, and 9 and and reduces DNA fragment...

T6108

Ki16425

355025-24-0

98%