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LPA Receptor

Lysophosphatidic acid (LPA) receptors are a group of G-protein-coupled receptors that are currently divided into six subtypes: LPA1, LPA2, LPA3, LPA4, LPA5 and LPA6. They belong to a family of lysophospholipid receptors that include S1P receptors.
Cat. No. Product name CAS No. Purity Chemical Structure
T14335 ASP6432 1282549-08-9 98%
ASP6432 is an antagonist of type 1 lysophosphatidic acid receptor (LPA1). For human LPA1 and rat LPA1, the IC50s are 11 nM and 30 nM , respectively.
T11875 LPA2 antagonist 2 36840-10-5 98%
LPA2 antagonist 2 is >480-fold more selective than LPA3 (IC50 of 13.85 μM).LPA2 antagonist 2 is a selective LPA2 antagonist with an IC50 of 28.3 nM and a Ki of 2...
T9699 TAK-615 1664335-55-0 98%
TAK-615 is commonly used to study pulmonary fibrosis and is a negative allosteric modulator of LPA1 receptors.
T7393 ONO-7300243 638132-34-0 98%
ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 : 0.16 µM).
T21654 1-Oleoyl lysophosphatidic acid sodium 325465-93-8 98%
1-Oleoyl lysophosphatidic acid sodium salt is an Endogenous agonist of LPA1 and LPA2
T22835 H2L5186303 139262-76-3 98%
H2L5186303 is an LPA2 antagonist and can be used in studies about asthma treatment.
T22070 DBIBB 1569309-92-7 98%
DBIBB is a non-lipid agonist of specific lysophosphatidic acid (LPA2) type 2 G-protein-coupled receptor. It is a potentially active molecule for the treatment of...
T6347 Ki16198 355025-13-7 98%
Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μ...
T15796 LX-1031 945976-76-1 98%
LX-1031 is an effective inhibitor of tryptophan 5-hydroxylase. LX-1031 decreases serotonin (5-HT) synthesis peripherally.
T7689 Tetradecyl Phosphonate 4671-75-4 98%
Tetradecyl phosphonate is a pan-antagonist of lysophosphatidic acid 1 (LPA1), LPA2, and LPA3 receptors.
T22812 GRI977143 325850-81-5 98%
GRI977143 is a selective and non-lipid agonist of LPA2 (EC50 = 3.3 μM). GRI977143 inhibits the activation of caspases 3, 7, 8, and 9 and and reduces DNA fragment...
T6108 Ki16425 355025-24-0 98%
Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively.
T4016 BMS-986020 1257213-50-5 98%
BMS-986020 is a selective antagonist of LPA1.
T23438 TC LPA5 4 1393814-38-4 98%
TC LPA5 4 is a LPA5 receptor antagonist.
T12684 Radioprotectin-1 1622006-09-0 98%
Radioprotectin-1 is a selective agonist of LPA2 with EC50 of 25 nM for murine LPA2 GPCR and exerts radioprotective and radiomitigative action.
T22834 H2L 5765834 420841-84-5 98%
H2L 5765834 is a lysophosphatidic acid receptors antagonist
T4278 AM966 1228690-19-4 98%
AM966, a excellent affinity, specific, oral LPA1(IC50=17 nM) antagonist, suppresses LPA-stimulated intracellular calcium release.
T2000 AM095 1345614-59-6 98%
AM095 is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively.
T4521 Edg-2 receptor inhibitor 1 1195941-38-8 98%
Edg-2 receptor inhibitor 1 is an Edg-2 receptor inhibitor extracted (IC50: <0.1 μM).
T10293 AM095 free acid 1228690-36-5 98%
AM095 (free acid) is a potent LPA1 receptor antagonist (IC50s: 0.98 and 0.73 μM for recombinant human or mouse LPA1).
ASP6432
T14335
ASP6432 is an antagonist of type 1 lysophosphatidic acid receptor (LPA1). For human LPA1 and rat LPA1, the IC50s are 11 nM and 30 nM , respectively.
LPA2 antagonist 2
T11875
LPA2 antagonist 2 is >480-fold more selective than LPA3 (IC50 of 13.85 μM).LPA2 antagonist 2 is a selective LPA2 antagonist with an IC50 of 28.3 nM and a Ki of 2...
TAK-615
T9699
TAK-615 is commonly used to study pulmonary fibrosis and is a negative allosteric modulator of LPA1 receptors.
ONO-7300243
T7393
ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 : 0.16 µM).
1-Oleoyl lysophosphatidic acid sodium
T21654
1-Oleoyl lysophosphatidic acid sodium salt is an Endogenous agonist of LPA1 and LPA2
H2L5186303
T22835
H2L5186303 is an LPA2 antagonist and can be used in studies about asthma treatment.
DBIBB
T22070
DBIBB is a non-lipid agonist of specific lysophosphatidic acid (LPA2) type 2 G-protein-coupled receptor. It is a potentially active molecule for the treatment of...
Ki16198
T6347
Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μ...
LX-1031
T15796
LX-1031 is an effective inhibitor of tryptophan 5-hydroxylase. LX-1031 decreases serotonin (5-HT) synthesis peripherally.
Tetradecyl Phosphonate
T7689
Tetradecyl phosphonate is a pan-antagonist of lysophosphatidic acid 1 (LPA1), LPA2, and LPA3 receptors.
GRI977143
T22812
GRI977143 is a selective and non-lipid agonist of LPA2 (EC50 = 3.3 μM). GRI977143 inhibits the activation of caspases 3, 7, 8, and 9 and and reduces DNA fragment...
Ki16425
T6108
Ki16425 is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively.
BMS-986020
T4016
BMS-986020 is a selective antagonist of LPA1.
TC LPA5 4
T23438
TC LPA5 4 is a LPA5 receptor antagonist.
Radioprotectin-1
T12684
Radioprotectin-1 is a selective agonist of LPA2 with EC50 of 25 nM for murine LPA2 GPCR and exerts radioprotective and radiomitigative action.
H2L 5765834
T22834
H2L 5765834 is a lysophosphatidic acid receptors antagonist
AM966
T4278
AM966, a excellent affinity, specific, oral LPA1(IC50=17 nM) antagonist, suppresses LPA-stimulated intracellular calcium release.
AM095
T2000
AM095 is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively.
Edg-2 receptor inhibitor 1
T4521
Edg-2 receptor inhibitor 1 is an Edg-2 receptor inhibitor extracted (IC50: <0.1 μM).
AM095 free acid
T10293
AM095 (free acid) is a potent LPA1 receptor antagonist (IC50s: 0.98 and 0.73 μM for recombinant human or mouse LPA1).