HER

The human epidermal growth factor receptor (HER) family of receptors plays a central role in the pathogenesis of several human cancers. They regulate cell growth, survival, and differentiation via multiple signal transduction pathways and participate in cellular proliferation and differentiation.

Cat. No.	Product name	CAS No.	Purity
T6827	Endoxifen Z-isomer hydrochloride	1032008-74-4	98%
T6827	Endoxifen HCl is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.
T10531	BGB-102	807640-87-5	98%
T10531	BGB-102 is a potent multi-kinase inhibitor against HER2, EGFR, and HER4 (IC50s: 18 nM, 9.6 nM, and 40.3 nM).
T11213L	Epertinib	908305-13-5	98%
T11213L	Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM). It displays a strong antitumor ...
T2518	ARRY-380 (analog )	937265-83-3	98%
T2518	ARRY-380 is a potent and selective HER2 inhibitor.
T2610	BMS-599626	714971-09-2	98%
T2610	BMS-599626 has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.
T11966	MCHR1 antagonist 2	863115-70-2	98%
T11966	MCHR1 antagonist 2 also inhibits hERG, with an IC50 of 4.0 nM in IMR-32 cells. MCHR1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1, w...
TQ0139	VU 0240551	893990-34-6	98%
TQ0139	VU 0240551 is a selective antagonist of neuronal K-Cl cotransporter KCC2 inhibitor with an IC50 of 560 nM. VU 0240551 inhibits L-type calcium channels and hERG.
T12912	Sigma-1 receptor antagonist 3	1639220-17-9	98%
T12912	Sigma-1 receptor antagonist 3 is a potent and selective antagonist of Sigma-1 (σ1) receptor(Ki : 1.14 nM), has the potential for the neuropathic pain.
T0801	Tannic acid	1401-55-4
T0801	Tannic acid is a novel hERG channel blocker.
T8189	Dihydroberberine	483-15-8	93.77%
T8189	Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities. It inhibits human ether-a-go-go-related gene (hERG) channel...
T30260	AZD-5672	780750-65-4	95.58%
T30260	AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM. AZD-5672 inhibits hERG cardiac ion channel binding and P-gp-mediated digoxin transport with IC50s of 7...
T4612	NS309	18711-16-5	95.87%
T4612	NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK ...
T13088	Tarloxotinib bromide	1636180-98-7	97.15%
T13088	Tarloxotinib bromide is an irreversible inhibitor of EGFR/HER2.
T7819	TAS0728	2088323-16-2	97.78%
T7819	TAS0728 is a HER2 inhibitor, with antitumor activity
T2630	Poziotinib	1092364-38-9	97.81%
T2630	Poziotinib(NOV120101; HM781-36B) is an irreversible HER1/2/4 inhibitor (IC50s: 3/5/23 nM).
T3673	Mollugin	55481-88-4	98%
T3673	Mollugin may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway. Mollugin as a candidate for ...
T2325	Neratinib	698387-09-6	98%
T2325	Neratinib (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively.
T6712	Tyrphostin AG 879	148741-30-4	98%
T6712	Tyrphostin AG 879 effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.
T14380	AZD7507	1041852-85-0	98.01%
T14380	AZD7507 is a CSF-1R inhibitor. It has antitumor activity.
T4S0544	Furanodienone	24268-41-5	98.32%
T4S0544	1. Furanodienone has effects on MCF-7 cells are mediated, at least in part, by inhibiting ERα signaling. 2. Furanodienone inhibits EGFR/HER2 signaling pathway in...