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HER

The human epidermal growth factor receptor (HER) family of receptors plays a central role in the pathogenesis of several human cancers. They regulate cell growth, survival, and differentiation via multiple signal transduction pathways and participate in cellular proliferation and differentiation.
Cat. No. Product name CAS No. Purity Chemical Structure
T6827 Endoxifen Z-isomer hydrochloride 1032008-74-4 98%
Endoxifen HCl is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.
T10531 BGB-102 807640-87-5 98%
BGB-102 is a potent multi-kinase inhibitor against HER2, EGFR, and HER4 (IC50s: 18 nM, 9.6 nM, and 40.3 nM).
T11213L Epertinib 908305-13-5 98%
Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM). It displays a strong antitumor ...
T2518 ARRY-380 (analog ) 937265-83-3 98%
ARRY-380 is a potent and selective HER2 inhibitor.
T2610 BMS-599626 714971-09-2 98%
BMS-599626 has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.
T11966 MCHR1 antagonist 2 863115-70-2 98%
MCHR1 antagonist 2 also inhibits hERG, with an IC50 of 4.0 nM in IMR-32 cells. MCHR1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1, w...
TQ0139 VU 0240551 893990-34-6 98%
VU 0240551 is a selective antagonist of neuronal K-Cl cotransporter KCC2 inhibitor with an IC50 of 560 nM. VU 0240551 inhibits L-type calcium channels and hERG.
T12912 Sigma-1 receptor antagonist 3 1639220-17-9 98%
Sigma-1 receptor antagonist 3 is a potent and selective antagonist of Sigma-1 (σ1) receptor(Ki : 1.14 nM), has the potential for the neuropathic pain.
T0801 Tannic acid 1401-55-4
Tannic acid is a novel hERG channel blocker.
T8189 Dihydroberberine 483-15-8 93.77%
Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities. It inhibits human ether-a-go-go-related gene (hERG) channel...
T30260 AZD-5672 780750-65-4 95.58%
AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM. AZD-5672 inhibits hERG cardiac ion channel binding and P-gp-mediated digoxin transport with IC50s of 7...
T4612 NS309 18711-16-5 95.87%
NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK ...
T13088 Tarloxotinib bromide 1636180-98-7 97.15%
Tarloxotinib bromide is an irreversible inhibitor of EGFR/HER2.
T7819 TAS0728 2088323-16-2 97.78%
TAS0728 is a HER2 inhibitor, with antitumor activity
T2630 Poziotinib 1092364-38-9 97.81%
Poziotinib(NOV120101; HM781-36B) is an irreversible HER1/2/4 inhibitor (IC50s: 3/5/23 nM).
T3673 Mollugin 55481-88-4 98%
Mollugin may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway. Mollugin as a candidate for ...
T2325 Neratinib 698387-09-6 98%
Neratinib (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively.
T6712 Tyrphostin AG 879 148741-30-4 98%
Tyrphostin AG 879 effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.
T14380 AZD7507 1041852-85-0 98.01%
AZD7507 is a CSF-1R inhibitor. It has antitumor activity.
T4S0544 Furanodienone 24268-41-5 98.32%
1. Furanodienone has effects on MCF-7 cells are mediated, at least in part, by inhibiting ERα signaling. 2. Furanodienone inhibits EGFR/HER2 signaling pathway in...
Endoxifen Z-isomer hydrochloride
T6827
Endoxifen HCl is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.
BGB-102
T10531
BGB-102 is a potent multi-kinase inhibitor against HER2, EGFR, and HER4 (IC50s: 18 nM, 9.6 nM, and 40.3 nM).
Epertinib
T11213L
Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM). It displays a strong antitumor ...
ARRY-380 (analog )
T2518
ARRY-380 is a potent and selective HER2 inhibitor.
BMS-599626
T2610
BMS-599626 has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.
MCHR1 antagonist 2
T11966
MCHR1 antagonist 2 also inhibits hERG, with an IC50 of 4.0 nM in IMR-32 cells. MCHR1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1, w...
VU 0240551
TQ0139
VU 0240551 is a selective antagonist of neuronal K-Cl cotransporter KCC2 inhibitor with an IC50 of 560 nM. VU 0240551 inhibits L-type calcium channels and hERG.
Sigma-1 receptor antagonist 3
T12912
Sigma-1 receptor antagonist 3 is a potent and selective antagonist of Sigma-1 (σ1) receptor(Ki : 1.14 nM), has the potential for the neuropathic pain.
Tannic acid
T0801
Tannic acid is a novel hERG channel blocker.
Dihydroberberine
T8189
Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities. It inhibits human ether-a-go-go-related gene (hERG) channel...
AZD-5672
T30260
AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM. AZD-5672 inhibits hERG cardiac ion channel binding and P-gp-mediated digoxin transport with IC50s of 7...
NS309
T4612
NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK ...
Tarloxotinib bromide
T13088
Tarloxotinib bromide is an irreversible inhibitor of EGFR/HER2.
TAS0728
T7819
TAS0728 is a HER2 inhibitor, with antitumor activity
Poziotinib
T2630
Poziotinib(NOV120101; HM781-36B) is an irreversible HER1/2/4 inhibitor (IC50s: 3/5/23 nM).
Mollugin
T3673
Mollugin may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway. Mollugin as a candidate for ...
Neratinib
T2325
Neratinib (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively.
Tyrphostin AG 879
T6712
Tyrphostin AG 879 effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.
AZD7507
T14380
AZD7507 is a CSF-1R inhibitor. It has antitumor activity.
Furanodienone
T4S0544
1. Furanodienone has effects on MCF-7 cells are mediated, at least in part, by inhibiting ERα signaling. 2. Furanodienone inhibits EGFR/HER2 signaling pathway in...
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