T6827 |
Endoxifen Z-isomer hydrochloride
|
1032008-74-4
|
98%
|
|
Endoxifen HCl is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.
|
T10531 |
BGB-102
|
807640-87-5
|
98%
|
|
BGB-102 is a potent multi-kinase inhibitor against HER2, EGFR, and HER4 (IC50s: 18 nM, 9.6 nM, and 40.3 nM).
|
T11213L |
Epertinib
|
908305-13-5
|
98%
|
|
Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM). It displays a strong antitumor ...
|
T2518 |
ARRY-380 (analog )
|
937265-83-3
|
98%
|
|
ARRY-380 is a potent and selective HER2 inhibitor.
|
T2610 |
BMS-599626
|
714971-09-2
|
98%
|
|
BMS-599626 has been used in trials studying the treatment of Cancer, Metastases, and HER2 or EGFR Expressing Advanced Solid Malignancies.
|
T11966 |
MCHR1 antagonist 2
|
863115-70-2
|
98%
|
|
MCHR1 antagonist 2 also inhibits hERG, with an IC50 of 4.0 nM in IMR-32 cells. MCHR1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1, w...
|
TQ0139 |
VU 0240551
|
893990-34-6
|
98%
|
|
VU 0240551 is a selective antagonist of neuronal K-Cl cotransporter KCC2 inhibitor with an IC50 of 560 nM. VU 0240551 inhibits L-type calcium channels and hERG.
|
T12912 |
Sigma-1 receptor antagonist 3
|
1639220-17-9
|
98%
|
|
Sigma-1 receptor antagonist 3 is a potent and selective antagonist of Sigma-1 (σ1) receptor(Ki : 1.14 nM), has the potential for the neuropathic pain.
|
T0801 |
Tannic acid
|
1401-55-4
|
|
|
Tannic acid is a novel hERG channel blocker.
|
T8189 |
Dihydroberberine
|
483-15-8
|
93.77%
|
|
Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities. It inhibits human ether-a-go-go-related gene (hERG) channel...
|
T30260 |
AZD-5672
|
780750-65-4
|
95.58%
|
|
AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM. AZD-5672 inhibits hERG cardiac ion channel binding and P-gp-mediated digoxin transport with IC50s of 7...
|
T4612 |
NS309
|
18711-16-5
|
95.87%
|
|
NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK ...
|
T13088 |
Tarloxotinib bromide
|
1636180-98-7
|
97.15%
|
|
Tarloxotinib bromide is an irreversible inhibitor of EGFR/HER2.
|
T7819 |
TAS0728
|
2088323-16-2
|
97.78%
|
|
TAS0728 is a HER2 inhibitor, with antitumor activity
|
T2630 |
Poziotinib
|
1092364-38-9
|
97.81%
|
|
Poziotinib(NOV120101; HM781-36B) is an irreversible HER1/2/4 inhibitor (IC50s: 3/5/23 nM).
|
T3673 |
Mollugin
|
55481-88-4
|
98%
|
|
Mollugin may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway. Mollugin as a candidate for ...
|
T2325 |
Neratinib
|
698387-09-6
|
98%
|
|
Neratinib (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively.
|
T6712 |
Tyrphostin AG 879
|
148741-30-4
|
98%
|
|
Tyrphostin AG 879 effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.
|
T14380 |
AZD7507
|
1041852-85-0
|
98.01%
|
|
AZD7507 is a CSF-1R inhibitor. It has antitumor activity.
|
T4S0544 |
Furanodienone
|
24268-41-5
|
98.32%
|
|
1. Furanodienone has effects on MCF-7 cells are mediated, at least in part, by inhibiting ERα signaling. 2. Furanodienone inhibits EGFR/HER2 signaling pathway in...
|