HER

The human epidermal growth factor receptor (HER) family of receptors plays a central role in the pathogenesis of several human cancers. They regulate cell growth, survival, and differentiation via multiple signal transduction pathways and participate in cellular proliferation and differentiation.

Cat. No.	Product name	CAS No.	Purity
T10531	BGB-102	807640-87-5	98%
T10531	BGB-102 is a potent multi-kinase inhibitor against HER2, EGFR, and HER4 (IC50s: 18 nM, 9.6 nM, and 40.3 nM).
T11213L	Epertinib	908305-13-5	98%
T11213L	Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM). It displays a strong antitumor ...
T6827	Endoxifen Z-isomer hydrochloride	1032008-74-4	98%
T6827	Endoxifen HCl is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.
T2610L	BMS-599626 2HCL(714971-09-2 Free base)	1781932-33-9	98%
T2610L	BMS-599626 2HCL is a BMS-599626 derivative.BMS-599626 is an orally available and selective dual inhibitor of HER1 and HER2 with IC50s of 20 and 30 nM, respective...
T67385	Neratinib maleate	915942-22-2	98%
T67385	Neratinib maleate is an irreversible, orally active and highly selective inhibitor of HER2 and EGFR with IC50 values of 59 nM and 92 nM, respectively.Neratinib m...
T11966	MCHR1 antagonist 2	863115-70-2	98%
T11966	MCHR1 antagonist 2 also inhibits hERG, with an IC50 of 4.0 nM in IMR-32 cells. MCHR1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1, w...
T12912	Sigma-1 receptor antagonist 3	1639220-17-9	98%
T12912	Sigma-1 receptor antagonist 3 is a potent and selective antagonist of Sigma-1 (σ1) receptor(Ki : 1.14 nM), has the potential for the neuropathic pain.
T5390	BMS-599626 Hydrochloride	873837-23-1	98%
T5390	BMS-599626 Hydrochloride is an orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases (IC50 =22, 32 and 190 nM, respectively) with potential a...
T8189	Dihydroberberine	483-15-8	98%
T8189	Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities. It inhibits human ether-a-go-go-related gene (hERG) channel...
T30260	AZD-5672	780750-65-4	98%
T30260	AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM. AZD-5672 inhibits hERG cardiac ion channel binding and P-gp-mediated digoxin transport with IC50s of 7...
T4612	NS309	18711-16-5	98%
T4612	NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK ...
T13088	Tarloxotinib bromide	1636180-98-7	98%
T13088	Tarloxotinib bromide is an irreversible inhibitor of EGFR/HER2.
T7819	TAS0728	2088323-16-2	98%
T7819	TAS0728 is a HER2 inhibitor, with antitumor activity
T6712	Tyrphostin AG 879	148741-30-4	98%
T6712	Tyrphostin AG 879 effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.
T12594	Pyrotinib dimaleate	1397922-61-0	98%
T12594	Pyrotinib dimaleate is a potent and selective dual inhibitor of EGFR/HER2 (IC50 s of 13 and 38 nM, respectively).
T2518	ARRY-380 (analog )	937265-83-3	98%
T2518	ARRY-380 is a potent and selective HER2 inhibitor.
T3673	Mollugin	55481-88-4	98%
T3673	Mollugin may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway. Mollugin as a candidate for ...
T4S0544	Furanodienone	24268-41-5	98%
T4S0544	1. Furanodienone has effects on MCF-7 cells are mediated, at least in part, by inhibiting ERα signaling. 2. Furanodienone inhibits EGFR/HER2 signaling pathway in...
T2325	Neratinib	698387-09-6	98%
T2325	Neratinib (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively.
T34760	SYR127063	871026-18-5	98%
T34760	SYR127063 (BDBM92454) is a potent and selective HER2 inhibitor, binds to HER2 in a reactive conformation.