T10531 |
BGB-102
|
807640-87-5
|
98%
|
|
BGB-102 is a potent multi-kinase inhibitor against HER2, EGFR, and HER4 (IC50s: 18 nM, 9.6 nM, and 40.3 nM).
|
T11213L |
Epertinib
|
908305-13-5
|
98%
|
|
Epertinib is a reversible and selective tyrosine kinase inhibitor of EGFR, HER2, and HER4 (IC50s: 1.48 nM, 7.15 nM, and 2.49 nM). It displays a strong antitumor ...
|
T6827 |
Endoxifen Z-isomer hydrochloride
|
1032008-74-4
|
98%
|
|
Endoxifen HCl is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.
|
T2610L |
BMS-599626 2HCL(714971-09-2 Free base)
|
1781932-33-9
|
98%
|
|
BMS-599626 2HCL is a BMS-599626 derivative.BMS-599626 is an orally available and selective dual inhibitor of HER1 and HER2 with IC50s of 20 and 30 nM, respective...
|
T67385 |
Neratinib maleate
|
915942-22-2
|
98%
|
|
Neratinib maleate is an irreversible, orally active and highly selective inhibitor of HER2 and EGFR with IC50 values of 59 nM and 92 nM, respectively.Neratinib m...
|
T11966 |
MCHR1 antagonist 2
|
863115-70-2
|
98%
|
|
MCHR1 antagonist 2 also inhibits hERG, with an IC50 of 4.0 nM in IMR-32 cells. MCHR1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1, w...
|
T12912 |
Sigma-1 receptor antagonist 3
|
1639220-17-9
|
98%
|
|
Sigma-1 receptor antagonist 3 is a potent and selective antagonist of Sigma-1 (σ1) receptor(Ki : 1.14 nM), has the potential for the neuropathic pain.
|
T5390 |
BMS-599626 Hydrochloride
|
873837-23-1
|
98%
|
|
BMS-599626 Hydrochloride is an orally bioavailable inhibitor of the HER1, HER2 and HER4 tyrosine kinases (IC50 =22, 32 and 190 nM, respectively) with potential a...
|
T8189 |
Dihydroberberine
|
483-15-8
|
98%
|
|
Dihydroberberine has anti-atherosclerotic, anti-inflammatory, hypolipidemic and antitumor activities. It inhibits human ether-a-go-go-related gene (hERG) channel...
|
T30260 |
AZD-5672
|
780750-65-4
|
98%
|
|
AZD-5672 is an antagonist of CCR5 with an IC50 of 0.32 nM. AZD-5672 inhibits hERG cardiac ion channel binding and P-gp-mediated digoxin transport with IC50s of 7...
|
T4612 |
NS309
|
18711-16-5
|
98%
|
|
NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK ...
|
T13088 |
Tarloxotinib bromide
|
1636180-98-7
|
98%
|
|
Tarloxotinib bromide is an irreversible inhibitor of EGFR/HER2.
|
T7819 |
TAS0728
|
2088323-16-2
|
98%
|
|
TAS0728 is a HER2 inhibitor, with antitumor activity
|
T6712 |
Tyrphostin AG 879
|
148741-30-4
|
98%
|
|
Tyrphostin AG 879 effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.
|
T12594 |
Pyrotinib dimaleate
|
1397922-61-0
|
98%
|
|
Pyrotinib dimaleate is a potent and selective dual inhibitor of EGFR/HER2 (IC50 s of 13 and 38 nM, respectively).
|
T2518 |
ARRY-380 (analog )
|
937265-83-3
|
98%
|
|
ARRY-380 is a potent and selective HER2 inhibitor.
|
T3673 |
Mollugin
|
55481-88-4
|
98%
|
|
Mollugin may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway. Mollugin as a candidate for ...
|
T4S0544 |
Furanodienone
|
24268-41-5
|
98%
|
|
1. Furanodienone has effects on MCF-7 cells are mediated, at least in part, by inhibiting ERα signaling. 2. Furanodienone inhibits EGFR/HER2 signaling pathway in...
|
T2325 |
Neratinib
|
698387-09-6
|
98%
|
|
Neratinib (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor for HER2 and EGFR (IC50: 59/92 nM), respectively.
|
T34760 |
SYR127063
|
871026-18-5
|
98%
|
|
SYR127063 (BDBM92454) is a potent and selective HER2 inhibitor, binds to HER2 in a reactive conformation.
|