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Angiogenesis FAK

FAK

PTK2 protein tyrosine kinase 2 (PTK2), also known as focal adhesion kinase (FAK), is a protein that, in humans, is encoded by the PTK2 gene. PTK2 is a focal adhesion-associated protein kinase involved in cellular adhesion (how cells stick to each other and their surroundings) and spreading processes (how cells move around). It has been shown that when FAK was blocked, breast cancer cells became less metastatic due to decreased mobility.
Cat No. product name
TN4046 Excisanin A ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
T1918 TAE226 NVP-TAE226 is an effective FAK inhibitor (IC50: 5.5 nM) and most effective to Pyk2(IC50: 3.5 nM); 10- to 100-fold less effective against IGF-1R, InsR, c-Met, and...
T1996 Defactinib Defactinib is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities.
T2281 GSK2256098 GSK-2256098 is a small molecule FAK kinase inhibitor.
T2655 CEP37440 CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).
T2809 (+)-Thalrugosine Fangchinoline is extracted from Stephania tetrandra S. Moore.
T3122 (+)-Fangchinoline Fangchinoline is extracted from Stephania tetrandra S. Moore.
T3391 Corosolic acid Corosolic acid contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. Corosolic acid exerts anticancer activities against H...
T6419 BMS536924 BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2...
T0263 Chloropyramine hydrochloride Chloropyramine hydrochloride is a histamine receptor H1 antagonist.
T2314 PF 431396 PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM).
T2465 PF562271 PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).
T2001 PF 573228 PF-573228 is an ATP-competitive FAK inhibitor. In a cell-free assay, the IC50 of FAK is 4 nM.
TN3139 5alpha-Hydroxycostic acid 5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.
T6177 PF-562271 besylate PF-562271 (besylate) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectiv...
T6936 PF03814735 PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and...
T4606 2119738-71-3
T21768 PF-562271 HCl PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-f...
T5480 BI-4464 BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC
T7119 Y15 Y15 is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, blocks tumor growth.
TQ0169 Inulicin Inulicin, an active compound isolated from Inula Britannica L, inhibits VEGF-mediated activation of Src and FAK.
T14997 Conteltinib Conteltinib is a multi-kinase inhibitor targeting FAK, Pyk2, and ALK. It has a significant inhibitory effect on FAK (IC50: 1.6 nM).
T15092 Defactinib hydrochloride Defactinib hydrochloride is a novel inhibitor of FAK which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner.
T11260 FAK inhibitor 2 FAK inhibitor 2, antitumor and anti-angiogenesis activitiesis ,is a potent focal adhesion kinase (FAK) inhibitor with an IC50  of 0.07 nM .
T8544 Masitinib mesylate Masitinib mesylate is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200 nM,540/800 nM,510 nM for human recombinant c-Kit;PDGFRα/β;LynB,respectiv...
T1950 PND1186 PND-1186 (VS-4718) is a reversible and specific FAK inhibitor (IC50: 1.5 nM).
Excisanin A
TN4046CAS 78536-37-5
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
TAE226
T1918CAS 761437-28-9
NVP-TAE226 is an effective FAK inhibitor (IC50: 5.5 nM) and most effective to Pyk2(IC50: 3.5 nM); 10- to 100-fold less effective against IGF-1R, InsR, c-Met, and...
Defactinib
T1996CAS 1073154-85-4
Defactinib is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities.
GSK2256098
T2281CAS 1224887-10-8
GSK-2256098 is a small molecule FAK kinase inhibitor.
CEP37440
T2655CAS 1391712-60-9
CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).
(+)-Thalrugosine
T2809CAS 33889-68-8
Fangchinoline is extracted from Stephania tetrandra S. Moore.
(+)-Fangchinoline
T3122CAS 436-77-1
Fangchinoline is extracted from Stephania tetrandra S. Moore.
Corosolic acid
T3391CAS 4547-24-4
Corosolic acid contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. Corosolic acid exerts anticancer activities against H...
BMS536924
T6419CAS 468740-43-4
BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2...
Chloropyramine hydrochloride
T0263CAS 6170-42-9
Chloropyramine hydrochloride is a histamine receptor H1 antagonist.
PF 431396
T2314CAS 717906-29-1
PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM).
PF562271
T2465CAS 717907-75-0
PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).
PF 573228
T2001CAS 869288-64-2
PF-573228 is an ATP-competitive FAK inhibitor. In a cell-free assay, the IC50 of FAK is 4 nM.
5alpha-Hydroxycostic acid
TN3139CAS 132185-83-2
5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.
PF-562271 besylate
T6177CAS 939791-38-5
PF-562271 (besylate) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectiv...
PF03814735
T6936CAS 942487-16-3
PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and...
2119738-71-3
T4606CAS 2119738-71-3
PF-562271 HCl
T21768CAS 939791-41-0
PF-562271 is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM in cell-free assays, ~10-fold less potent for Pyk2 than FAK and >100-f...
BI-4464
T5480CAS 1227948-02-8
BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC
Y15
T7119CAS 4506-66-5
Y15 is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, blocks tumor growth.
Inulicin
TQ0169CAS 33627-41-7
Inulicin, an active compound isolated from Inula Britannica L, inhibits VEGF-mediated activation of Src and FAK.
Conteltinib
T14997CAS 1384860-29-0
Conteltinib is a multi-kinase inhibitor targeting FAK, Pyk2, and ALK. It has a significant inhibitory effect on FAK (IC50: 1.6 nM).
Defactinib hydrochloride
T15092CAS 1073160-26-5
Defactinib hydrochloride is a novel inhibitor of FAK which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner.
FAK inhibitor 2
T11260CAS 2354405-14-2
FAK inhibitor 2, antitumor and anti-angiogenesis activitiesis ,is a potent focal adhesion kinase (FAK) inhibitor with an IC50  of 0.07 nM .
Masitinib mesylate
T8544CAS 1048007-93-7
Masitinib mesylate is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200 nM,540/800 nM,510 nM for human recombinant c-Kit;PDGFRα/β;LynB,respectiv...
PND1186
T1950CAS 1061353-68-1
PND-1186 (VS-4718) is a reversible and specific FAK inhibitor (IC50: 1.5 nM).