T4606 |
2119738-71-3
|
2119738-71-3
|
98%
|
|
|
T15092 |
Defactinib hydrochloride
|
1073160-26-5
|
98%
|
|
Defactinib hydrochloride is a novel inhibitor of FAK. Which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner.
|
T6936 |
PF-03814735
|
942487-16-3
|
98%
|
|
PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and...
|
TN3139 |
5α-Hydroxycostic acid
|
132185-83-2
|
98%
|
|
5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.
|
T11260 |
FAK inhibitor 2
|
2354405-14-2
|
98%
|
|
FAK inhibitor 2, antitumor and anti-angiogenesis activitiesis ,is a potent focal adhesion kinase (FAK) inhibitor with an IC50 of 0.07 nM .
|
TN4046 |
Excisanin A
|
78536-37-5
|
98%
|
|
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
|
T14997 |
Conteltinib
|
1384860-29-0
|
98%
|
|
Conteltinib is a multi-kinase inhibitor targeting FAK, Pyk2, and ALK. It has a significant inhibitory effect on FAK (IC50: 1.6 nM).
|
T2609 |
Masitinib
|
790299-79-5
|
98%
|
|
Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 2008 it has ...
|
T0263 |
Chloropyramine hydrochloride
|
6170-42-9
|
98%
|
|
Chloropyramine hydrochloride is a histamine receptor H1 antagonist.
|
TQ0169 |
Inulicin
|
33627-41-7
|
98%
|
|
Inulicin, an active compound isolated from Inula Britannica L, inhibits VEGF-mediated activation of Src and FAK.
|
T1950 |
PND-1186
|
1061353-68-1
|
98%
|
|
PND-1186 (VS-4718) is a reversible and specific FAK inhibitor (IC50: 1.5 nM).
|
T9576 |
AMP-945
|
1393653-34-3
|
98%
|
|
AMP-945 is a proprietary focal adhesion kinase (FAK) inhibitor.
|
T2809 |
(R)-Fangchinoline
|
33889-68-8
|
98%
|
|
Fangchinoline is extracted from Stephania tetrandra S. Moore.
|
T3391 |
Corosolic acid
|
4547-24-4
|
98%
|
|
Corosolic acid contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. Corosolic acid exerts anticancer activities against H...
|
T6177 |
PF-562271 besylate
|
939791-38-5
|
98%
|
|
PF-562271 (besylate) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectiv...
|
T67843 |
GSK215
|
2743427-26-9
|
98%
|
|
GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader (pDC50= 8.4). GSK215 is designed by the FAK inhibitor VS-4718 and a binder for the V...
|
T6419 |
BMS-536924
|
468740-43-4
|
98%
|
|
BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2...
|
TN1433 |
Batatasin III
|
56684-87-8
|
98%
|
|
Batatasin III inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition and FAK-AKT signals and possesses anti-cancer activities...
|
T2655 |
CEP-37440
|
1391712-60-9
|
98%
|
|
CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).
|
T3041 |
ALK inhibitor 2
|
761438-38-4
|
98%
|
|
ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.
|