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Inhibitors Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling DNA Damage/DNA Repair Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation JAK/STAT signaling MAPK
Membrane transporter/Ion channel Metabolism Microbiology/Virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling Proteases/Proteasome Stem Cells Tyrosine Kinase/Adaptors Ubiquitination PROTAC Others
Compound Libraries Focused Bioactive Libraries General Bioactive Libraries Approved / Repurposing Disease Focused Target / Pathway Focused Characteristic Bioactive Libraries Natural Product Libraries Natural Product Library for HTS Characteristic Natural Product Libraries Natural Product Derivatives Libraries Natural Product Library for CADD Drug-like Compound Libraries Fragment Libraries Custom Compound Library
Signaling Pathways Angiogenesis Apoptosis Autophagy Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling
DNA Damage/DNA Repair Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation JAK/STAT signaling MAPK Membrane transporter/Ion channel
Metabolism Microbiology/Virology Neuroscience NF-Κb oxidation-reduction PI3K/Akt/mTOR signaling Proteases/Proteasome
Stem Cells Tyrosine Kinase/Adaptors Ubiquitination PROTAC Others
Focused Bioactive Libraries General Bioactive Libraries Approved / Repurposing Disease Focused Target / Pathway Focused Characteristic Bioactive Libraries
Natural Product Libraries Natural Product Library for HTS Characteristic Natural Product Libraries Natural Product Derivatives Libraries Natural Product Library for CADD
Drug-like Compound Libraries Compound Libraries for HTS/HCS
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FAK

Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, is the first intracellular step in the signal transduction cascade initiated by the attachment of an integrin to the extracellular matrix at points known as focal adhesions. FAK has a key role in cellular migration and motility.
Cat. No. Product name CAS No. Purity Chemical Structure
T4606 2119738-71-3 2119738-71-3 98%
T15092 Defactinib hydrochloride 1073160-26-5 98%
Defactinib hydrochloride is a novel inhibitor of FAK. Which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner.
T6936 PF-03814735 942487-16-3 98%
PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and...
TN3139 5α-Hydroxycostic acid 132185-83-2 98%
5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.
T11260 FAK inhibitor 2 2354405-14-2 98%
FAK inhibitor 2, antitumor and anti-angiogenesis activitiesis ,is a potent focal adhesion kinase (FAK) inhibitor with an IC50 of 0.07 nM .
TN4046 Excisanin A 78536-37-5 98%
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
T14997 Conteltinib 1384860-29-0 98%
Conteltinib is a multi-kinase inhibitor targeting FAK, Pyk2, and ALK. It has a significant inhibitory effect on FAK (IC50: 1.6 nM).
T2609 Masitinib 790299-79-5 98%
Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 2008 it has ...
T0263 Chloropyramine hydrochloride 6170-42-9 98%
Chloropyramine hydrochloride is a histamine receptor H1 antagonist.
TQ0169 Inulicin 33627-41-7 98%
Inulicin, an active compound isolated from Inula Britannica L, inhibits VEGF-mediated activation of Src and FAK.
T1950 PND-1186 1061353-68-1 98%
PND-1186 (VS-4718) is a reversible and specific FAK inhibitor (IC50: 1.5 nM).
T9576 AMP-945 1393653-34-3 98%
AMP-945 is a proprietary focal adhesion kinase (FAK) inhibitor.
T2809 (R)-Fangchinoline 33889-68-8 98%
Fangchinoline is extracted from Stephania tetrandra S. Moore.
T3391 Corosolic acid 4547-24-4 98%
Corosolic acid contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. Corosolic acid exerts anticancer activities against H...
T6177 PF-562271 besylate 939791-38-5 98%
PF-562271 (besylate) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectiv...
T67843 GSK215 2743427-26-9 98%
GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader (pDC50= 8.4). GSK215 is designed by the FAK inhibitor VS-4718 and a binder for the V...
T6419 BMS-536924 468740-43-4 98%
BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2...
TN1433 Batatasin III 56684-87-8 98%
Batatasin III inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition and FAK-AKT signals and possesses anti-cancer activities...
T2655 CEP-37440 1391712-60-9 98%
CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).
T3041 ALK inhibitor 2 761438-38-4 98%
ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.
2119738-71-3
T4606
Defactinib hydrochloride
T15092
Defactinib hydrochloride is a novel inhibitor of FAK. Which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-dependent manner.
PF-03814735
T6936
PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and...
5α-Hydroxycostic acid
TN3139
5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.
FAK inhibitor 2
T11260
FAK inhibitor 2, antitumor and anti-angiogenesis activitiesis ,is a potent focal adhesion kinase (FAK) inhibitor with an IC50 of 0.07 nM .
Excisanin A
TN4046
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
Conteltinib
T14997
Conteltinib is a multi-kinase inhibitor targeting FAK, Pyk2, and ALK. It has a significant inhibitory effect on FAK (IC50: 1.6 nM).
Masitinib
T2609
Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 2008 it has ...
Chloropyramine hydrochloride
T0263
Chloropyramine hydrochloride is a histamine receptor H1 antagonist.
Inulicin
TQ0169
Inulicin, an active compound isolated from Inula Britannica L, inhibits VEGF-mediated activation of Src and FAK.
PND-1186
T1950
PND-1186 (VS-4718) is a reversible and specific FAK inhibitor (IC50: 1.5 nM).
AMP-945
T9576
AMP-945 is a proprietary focal adhesion kinase (FAK) inhibitor.
(R)-Fangchinoline
T2809
Fangchinoline is extracted from Stephania tetrandra S. Moore.
Corosolic acid
T3391
Corosolic acid contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. Corosolic acid exerts anticancer activities against H...
PF-562271 besylate
T6177
PF-562271 (besylate) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectiv...
GSK215
T67843
GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader (pDC50= 8.4). GSK215 is designed by the FAK inhibitor VS-4718 and a binder for the V...
BMS-536924
T6419
BMS-536924 is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2...
Batatasin III
TN1433
Batatasin III inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition and FAK-AKT signals and possesses anti-cancer activities...
CEP-37440
T2655
CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).
ALK inhibitor 2
T3041
ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.
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