FAK

Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, is the first intracellular step in the signal transduction cascade initiated by the attachment of an integrin to the extracellular matrix at points known as focal adhesions. FAK has a key role in cellular migration and motility.

Cat. No.	Product name	CAS No.	Purity
T4606	2119738-71-3	2119738-71-3	99.23%
T4606	Compound 2119738-71-3 interacts with the FAK receptor.
T15092	Defactinib hydrochloride	1073160-26-5	98.06%
T15092	Defactinib hydrochloride (PF 04554878 hydrochloride) is a novel inhibitor of FAK. Which inhibits FAK phosphorylation at the Tyr397 site in a time- and dose-depen...
T79688	FAK-IN-11		98%
T79688	FAK-IN-11 (Compound 4l), a FAK inhibitor, specifically targets the ATP binding pocket of FAK to prevent its phosphorylation. It exhibits cytotoxic effects on MDA...
T82420	FAK-IN-12		98%
T82420	FAK-IN-12 (Compound 12S) is a selective FAK inhibitor with an IC50 of 47 nM. It effectively suppresses proliferation of MGC-803, HCT-116, and KYSE30 cells with I...
T6936	PF-03814735	942487-16-3	98%
T6936	PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and...
TN3139	5α-Hydroxycostic acid	132185-83-2	98%
TN3139	5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.
T11260	FAK inhibitor 2	2354405-14-2	98%
T11260	FAK inhibitor 2, antitumor and anti-angiogenesis activitiesis ,is a potent focal adhesion kinase (FAK) inhibitor with an IC50 of 0.07 nM .
TN4046	Excisanin A	78536-37-5	98%
TN4046	ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
T3122	Fangchinoline	436-77-1	99.98%
T3122	Fangchinoline (Tetrandrine B) is extracted from Stephania tetrandra S. Moore.
T2609	Masitinib	790299-79-5	99.91%
T2609	Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs. Since its introduction in November 200...
T64167	Ifebemtinib	1227948-82-4	99.82%
T64167	Ifebemtinib (BI-853520) is an orally active and potent inhibitor of adhesion plaque kinase (FAK) (IC50=1 nM) with anti-tumour activity that inhibits globule form...
T1996	Defactinib	1073154-85-4	99.8%
T1996	Defactinib (VS-6063) is an orally bioavailable, small-molecule focal adhesion kinase (FAK) inhibitor with potential antiangiogenic and antineoplastic activities....
T77718	FAK-IN-10	491839-65-7	99.78%
T77718	FAK-IN-10 is an inhibitor of FAK (IC50:76.3 μM).FAK-IN-10 z MCF-7 and A431 cell lines showed antitumor activity with IC50 of 4.23 and 0.78 μM, respectively.
TQ0169	Inulicin	33627-41-7	99.77%
TQ0169	Inulicin (1-O-Acetylbritannilactone), an active compound isolated from Inula Britannica L, inhibits VEGF-mediated activation of Src and FAK.
T1950	PND-1186	1061353-68-1	99.75%
T1950	PND-1186 (VS-4718) is a reversible and specific FAK inhibitor (IC50: 1.5 nM).
T9576	AMP-945	1393653-34-3	99.60%
T9576	AMP-945 is a proprietary focal adhesion kinase (FAK) inhibitor.
T2809	(R)-Fangchinoline	33889-68-8	99.58%
T2809	(R)-Fangchinoline ((+)-Thalrugosine) is extracted from Stephania tetrandra S. Moore.
T14997	Conteltinib	1384860-29-0	99.54%
T14997	Conteltinib (CT-707) is an enzyme inhibitor with antitumor activity targeting FAK, ALK, and Pyk2.Conteltinib exhibits significant inhibition of FAK, overcomes hy...
T3391	Corosolic acid	4547-24-4	99.52%
T3391	Corosolic acid (Colosic acid) contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. Corosolic acid exerts anticancer activ...
T6177	PF-562271 besylate	939791-38-5	99.5%
T6177	PF-562271 besylate (PF-00562271 Besylate) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK a...